Browse EPHA7

Summary
SymbolEPHA7
NameEPH receptor A7
Aliases Hek11; EHK-3; EHK3; EK11; EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; receptor protein ......
Chromosomal Location6q16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein
Domain PF14575 Ephrin type-A receptor 2 transmembrane domain
PF01404 Ephrin receptor ligand binding domain
PF07699 Putative ephrin-receptor like
PF00041 Fibronectin type III domain
PF07714 Protein tyrosine kinase
PF00536 SAM domain (Sterile alpha motif)
Function

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0001655 urogenital system development
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007416 synapse assembly
GO:0008361 regulation of cell size
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010771 negative regulation of cell morphogenesis involved in differentiation
GO:0010975 regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0016049 cell growth
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0022407 regulation of cell-cell adhesion
GO:0022604 regulation of cell morphogenesis
GO:0030308 negative regulation of cell growth
GO:0031290 retinal ganglion cell axon guidance
GO:0031345 negative regulation of cell projection organization
GO:0031952 regulation of protein autophosphorylation
GO:0032535 regulation of cellular component size
GO:0035239 tube morphogenesis
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045665 negative regulation of neuron differentiation
GO:0045926 negative regulation of growth
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0048588 developmental cell growth
GO:0048638 regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048668 collateral sprouting
GO:0048670 regulation of collateral sprouting
GO:0048671 negative regulation of collateral sprouting
GO:0048755 branching morphogenesis of a nerve
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050768 negative regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050803 regulation of synapse structure or activity
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0050919 negative chemotaxis
GO:0051402 neuron apoptotic process
GO:0051961 negative regulation of nervous system development
GO:0051963 regulation of synapse assembly
GO:0051964 negative regulation of synapse assembly
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0061387 regulation of extent of cell growth
GO:0061564 axon development
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070997 neuron death
GO:0072001 renal system development
GO:0072073 kidney epithelium development
GO:0072176 nephric duct development
GO:0072178 nephric duct morphogenesis
GO:0090066 regulation of anatomical structure size
GO:0097485 neuron projection guidance
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:2000116 regulation of cysteine-type endopeptidase activity
Molecular Function GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0008046 axon guidance receptor activity
GO:0019199 transmembrane receptor protein kinase activity
GO:0045499 chemorepellent activity
GO:0046875 ephrin receptor binding
Cellular Component GO:0030425 dendrite
GO:0031594 neuromuscular junction
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0045211 postsynaptic membrane
GO:0097060 synaptic membrane
GO:0098794 postsynapse
> KEGG and Reactome Pathway
 
KEGG hsa04360 Axon guidance
Reactome R-HSA-422475: Axon guidance
R-HSA-1266738: Developmental Biology
R-HSA-2682334: EPH-Ephrin signaling
R-HSA-3928665: EPH-ephrin mediated repulsion of cells
R-HSA-3928663: EPHA-mediated growth cone collapse
Summary
SymbolEPHA7
NameEPH receptor A7
Aliases Hek11; EHK-3; EHK3; EK11; EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; receptor protein ......
Chromosomal Location6q16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between EPHA7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolEPHA7
NameEPH receptor A7
Aliases Hek11; EHK-3; EHK3; EK11; EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; receptor protein ......
Chromosomal Location6q16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of EPHA7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolEPHA7
NameEPH receptor A7
Aliases Hek11; EHK-3; EHK3; EK11; EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; receptor protein ......
Chromosomal Location6q16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of EPHA7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0330.881
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.090.875
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8700.999
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.7450.322
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.0180.55
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3950.84
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3380.651
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.0540.447
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.440.771
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.6670.621
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.1630.532
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1080.728
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of EPHA7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277333.31122.30.0146
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275933.313.619.70.0432
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211723.85.917.90.197
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.19.1140.596
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.97.40.51
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolEPHA7
NameEPH receptor A7
Aliases Hek11; EHK-3; EHK3; EK11; EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; receptor protein ......
Chromosomal Location6q16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EPHA7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolEPHA7
NameEPH receptor A7
Aliases Hek11; EHK-3; EHK3; EK11; EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; receptor protein ......
Chromosomal Location6q16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EPHA7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EPHA7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolEPHA7
NameEPH receptor A7
Aliases Hek11; EHK-3; EHK3; EK11; EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; receptor protein ......
Chromosomal Location6q16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EPHA7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolEPHA7
NameEPH receptor A7
Aliases Hek11; EHK-3; EHK3; EK11; EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; receptor protein ......
Chromosomal Location6q16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of EPHA7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolEPHA7
NameEPH receptor A7
Aliases Hek11; EHK-3; EHK3; EK11; EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; receptor protein ......
Chromosomal Location6q16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between EPHA7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolEPHA7
NameEPH receptor A7
Aliases Hek11; EHK-3; EHK3; EK11; EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; receptor protein ......
Chromosomal Location6q16.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting EPHA7 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting EPHA7.
ID Name Drug Type Targets #Targets
DB079705-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamideSmall MoleculeEPHA71