Summary | |
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Symbol | EPN3 |
Name | epsin 3 |
Aliases | FLJ20778; MGC129899; EPS-15-interacting protein 3; Epsin-3 |
Chromosomal Location | 17q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cytoplasm, perinuclear region Cytoplasmic vesicle, clathrin-coated vesicle Nucleus Note=Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus. |
Domain |
PF01417 ENTH domain PF02809 Ubiquitin interaction motif |
Function |
- |
Biological Process | - |
Molecular Function |
GO:1990175 EH domain binding |
Cellular Component |
GO:0005905 clathrin-coated pit GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0098589 membrane region |
KEGG |
hsa04144 Endocytosis |
Reactome | - |
Summary | |
---|---|
Symbol | EPN3 |
Name | epsin 3 |
Aliases | FLJ20778; MGC129899; EPS-15-interacting protein 3; Epsin-3 |
Chromosomal Location | 17q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EPN3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EPN3 |
Name | epsin 3 |
Aliases | FLJ20778; MGC129899; EPS-15-interacting protein 3; Epsin-3 |
Chromosomal Location | 17q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EPN3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | EPN3 |
Name | epsin 3 |
Aliases | FLJ20778; MGC129899; EPS-15-interacting protein 3; Epsin-3 |
Chromosomal Location | 17q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EPN3 in various data sets.
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Points in the above scatter plot represent the mutation difference of EPN3 in various data sets.
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Summary | |
---|---|
Symbol | EPN3 |
Name | epsin 3 |
Aliases | FLJ20778; MGC129899; EPS-15-interacting protein 3; Epsin-3 |
Chromosomal Location | 17q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EPN3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | EPN3 |
Name | epsin 3 |
Aliases | FLJ20778; MGC129899; EPS-15-interacting protein 3; Epsin-3 |
Chromosomal Location | 17q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EPN3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EPN3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | EPN3 |
Name | epsin 3 |
Aliases | FLJ20778; MGC129899; EPS-15-interacting protein 3; Epsin-3 |
Chromosomal Location | 17q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EPN3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | EPN3 |
Name | epsin 3 |
Aliases | FLJ20778; MGC129899; EPS-15-interacting protein 3; Epsin-3 |
Chromosomal Location | 17q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EPN3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EPN3 |
Name | epsin 3 |
Aliases | FLJ20778; MGC129899; EPS-15-interacting protein 3; Epsin-3 |
Chromosomal Location | 17q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EPN3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |