Summary | |
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Symbol | EPS15L1 |
Name | epidermal growth factor receptor pathway substrate 15-like 1 |
Aliases | eps15R; epidermal growth factor receptor substrate EPS15R; eps15-related protein; Epidermal growth factor re ...... |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Peripheral membrane protein Nucleus Membrane, coated pit Note=Localized to plasma membrane coated pits. |
Domain |
PF12763 Cytoskeletal-regulatory complex EF hand |
Function |
Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. |
Biological Process |
GO:0007173 epidermal growth factor receptor signaling pathway GO:0038127 ERBB signaling pathway GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway GO:1901184 regulation of ERBB signaling pathway GO:1901185 negative regulation of ERBB signaling pathway |
Molecular Function |
GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005905 clathrin-coated pit GO:0005913 cell-cell adherens junction GO:0030117 membrane coat GO:0030118 clathrin coat GO:0030132 clathrin coat of coated pit GO:0048475 coated membrane GO:0098589 membrane region |
KEGG |
hsa04144 Endocytosis |
Reactome |
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-182971: EGFR downregulation R-HSA-199991: Membrane Trafficking R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | EPS15L1 |
Name | epidermal growth factor receptor pathway substrate 15-like 1 |
Aliases | eps15R; epidermal growth factor receptor substrate EPS15R; eps15-related protein; Epidermal growth factor re ...... |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EPS15L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EPS15L1 |
Name | epidermal growth factor receptor pathway substrate 15-like 1 |
Aliases | eps15R; epidermal growth factor receptor substrate EPS15R; eps15-related protein; Epidermal growth factor re ...... |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EPS15L1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | EPS15L1 |
Name | epidermal growth factor receptor pathway substrate 15-like 1 |
Aliases | eps15R; epidermal growth factor receptor substrate EPS15R; eps15-related protein; Epidermal growth factor re ...... |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EPS15L1 in various data sets.
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Points in the above scatter plot represent the mutation difference of EPS15L1 in various data sets.
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Summary | |
---|---|
Symbol | EPS15L1 |
Name | epidermal growth factor receptor pathway substrate 15-like 1 |
Aliases | eps15R; epidermal growth factor receptor substrate EPS15R; eps15-related protein; Epidermal growth factor re ...... |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EPS15L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | EPS15L1 |
Name | epidermal growth factor receptor pathway substrate 15-like 1 |
Aliases | eps15R; epidermal growth factor receptor substrate EPS15R; eps15-related protein; Epidermal growth factor re ...... |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EPS15L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EPS15L1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | EPS15L1 |
Name | epidermal growth factor receptor pathway substrate 15-like 1 |
Aliases | eps15R; epidermal growth factor receptor substrate EPS15R; eps15-related protein; Epidermal growth factor re ...... |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EPS15L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | EPS15L1 |
Name | epidermal growth factor receptor pathway substrate 15-like 1 |
Aliases | eps15R; epidermal growth factor receptor substrate EPS15R; eps15-related protein; Epidermal growth factor re ...... |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EPS15L1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EPS15L1 |
Name | epidermal growth factor receptor pathway substrate 15-like 1 |
Aliases | eps15R; epidermal growth factor receptor substrate EPS15R; eps15-related protein; Epidermal growth factor re ...... |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EPS15L1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | EPS15L1 |
Name | epidermal growth factor receptor pathway substrate 15-like 1 |
Aliases | eps15R; epidermal growth factor receptor substrate EPS15R; eps15-related protein; Epidermal growth factor re ...... |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EPS15L1 collected from DrugBank database. |
There is no record. |