Summary | |
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Symbol | ERH |
Name | enhancer of rudimentary homolog (Drosophila) |
Aliases | DROER; enhancer of rudimentary (Drosophila) homolog; Enhancer of rudimentary homolog |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF01133 Enhancer of rudimentary |
Function |
May have a role in the cell cycle. |
Biological Process |
GO:0006213 pyrimidine nucleoside metabolic process GO:0006220 pyrimidine nucleotide metabolic process GO:0006221 pyrimidine nucleotide biosynthetic process GO:0007219 Notch signaling pathway GO:0008593 regulation of Notch signaling pathway GO:0009116 nucleoside metabolic process GO:0009165 nucleotide biosynthetic process GO:0045747 positive regulation of Notch signaling pathway GO:0072527 pyrimidine-containing compound metabolic process GO:0072528 pyrimidine-containing compound biosynthetic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901657 glycosyl compound metabolic process |
Molecular Function |
GO:0008327 methyl-CpG binding |
Cellular Component |
GO:0030496 midbody GO:0034708 methyltransferase complex GO:0034709 methylosome |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | ERH |
Name | enhancer of rudimentary homolog (Drosophila) |
Aliases | DROER; enhancer of rudimentary (Drosophila) homolog; Enhancer of rudimentary homolog |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ERH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ERH |
Name | enhancer of rudimentary homolog (Drosophila) |
Aliases | DROER; enhancer of rudimentary (Drosophila) homolog; Enhancer of rudimentary homolog |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ERH in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ERH |
Name | enhancer of rudimentary homolog (Drosophila) |
Aliases | DROER; enhancer of rudimentary (Drosophila) homolog; Enhancer of rudimentary homolog |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ERH in various data sets.
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Points in the above scatter plot represent the mutation difference of ERH in various data sets.
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Summary | |
---|---|
Symbol | ERH |
Name | enhancer of rudimentary homolog (Drosophila) |
Aliases | DROER; enhancer of rudimentary (Drosophila) homolog; Enhancer of rudimentary homolog |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ERH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ERH |
Name | enhancer of rudimentary homolog (Drosophila) |
Aliases | DROER; enhancer of rudimentary (Drosophila) homolog; Enhancer of rudimentary homolog |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ERH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ERH. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ERH |
Name | enhancer of rudimentary homolog (Drosophila) |
Aliases | DROER; enhancer of rudimentary (Drosophila) homolog; Enhancer of rudimentary homolog |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ERH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ERH |
Name | enhancer of rudimentary homolog (Drosophila) |
Aliases | DROER; enhancer of rudimentary (Drosophila) homolog; Enhancer of rudimentary homolog |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ERH expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ERH |
Name | enhancer of rudimentary homolog (Drosophila) |
Aliases | DROER; enhancer of rudimentary (Drosophila) homolog; Enhancer of rudimentary homolog |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ERH and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ERH |
Name | enhancer of rudimentary homolog (Drosophila) |
Aliases | DROER; enhancer of rudimentary (Drosophila) homolog; Enhancer of rudimentary homolog |
Chromosomal Location | 14q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ERH collected from DrugBank database. |
There is no record. |