Summary | |
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Symbol | ERMN |
Name | ermin, ERM-like protein |
Aliases | JN; ERMIN; juxtanodin; KIAA1189 |
Chromosomal Location | 2q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton |
Domain | - |
Function |
Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). |
Biological Process |
GO:0001763 morphogenesis of a branching structure GO:0007015 actin filament organization GO:0008360 regulation of cell shape GO:0022604 regulation of cell morphogenesis |
Molecular Function |
GO:0003779 actin binding GO:0051015 actin filament binding |
Cellular Component |
GO:0005938 cell cortex GO:0030175 filopodium GO:0030424 axon GO:0033267 axon part GO:0033269 internode region of axon GO:0033270 paranode region of axon GO:0043025 neuronal cell body GO:0043209 myelin sheath GO:0044297 cell body GO:0044304 main axon GO:0098858 actin-based cell projection GO:0099568 cytoplasmic region |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ERMN |
Name | ermin, ERM-like protein |
Aliases | JN; ERMIN; juxtanodin; KIAA1189 |
Chromosomal Location | 2q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ERMN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ERMN |
Name | ermin, ERM-like protein |
Aliases | JN; ERMIN; juxtanodin; KIAA1189 |
Chromosomal Location | 2q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ERMN in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ERMN |
Name | ermin, ERM-like protein |
Aliases | JN; ERMIN; juxtanodin; KIAA1189 |
Chromosomal Location | 2q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ERMN in various data sets.
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Points in the above scatter plot represent the mutation difference of ERMN in various data sets.
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Summary | |
---|---|
Symbol | ERMN |
Name | ermin, ERM-like protein |
Aliases | JN; ERMIN; juxtanodin; KIAA1189 |
Chromosomal Location | 2q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ERMN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ERMN |
Name | ermin, ERM-like protein |
Aliases | JN; ERMIN; juxtanodin; KIAA1189 |
Chromosomal Location | 2q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ERMN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ERMN. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ERMN |
Name | ermin, ERM-like protein |
Aliases | JN; ERMIN; juxtanodin; KIAA1189 |
Chromosomal Location | 2q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ERMN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ERMN |
Name | ermin, ERM-like protein |
Aliases | JN; ERMIN; juxtanodin; KIAA1189 |
Chromosomal Location | 2q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ERMN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ERMN |
Name | ermin, ERM-like protein |
Aliases | JN; ERMIN; juxtanodin; KIAA1189 |
Chromosomal Location | 2q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ERMN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |