Summary | |
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Symbol | ESPL1 |
Name | extra spindle pole bodies like 1, separase |
Aliases | KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. |
Domain | - |
Function |
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. |
Biological Process |
GO:0000070 mitotic sister chromatid segregation GO:0000212 meiotic spindle organization GO:0000226 microtubule cytoskeleton organization GO:0000819 sister chromatid segregation GO:0000910 cytokinesis GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007063 regulation of sister chromatid cohesion GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007091 metaphase/anaphase transition of mitotic cell cycle GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007346 regulation of mitotic cell cycle GO:0010639 negative regulation of organelle organization GO:0010948 negative regulation of cell cycle process GO:0010965 regulation of mitotic sister chromatid separation GO:0030071 regulation of mitotic metaphase/anaphase transition GO:0033044 regulation of chromosome organization GO:0033045 regulation of sister chromatid segregation GO:0033046 negative regulation of sister chromatid segregation GO:0033047 regulation of mitotic sister chromatid segregation GO:0040001 establishment of mitotic spindle localization GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044784 metaphase/anaphase transition of cell cycle GO:0045132 meiotic chromosome segregation GO:0045143 homologous chromosome segregation GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045840 positive regulation of mitotic nuclear division GO:0045842 positive regulation of mitotic metaphase/anaphase transition GO:0045875 negative regulation of sister chromatid cohesion GO:0045931 positive regulation of mitotic cell cycle GO:0051293 establishment of spindle localization GO:0051304 chromosome separation GO:0051306 mitotic sister chromatid separation GO:0051307 meiotic chromosome separation GO:0051321 meiotic cell cycle GO:0051640 organelle localization GO:0051653 spindle localization GO:0051656 establishment of organelle localization GO:0051783 regulation of nuclear division GO:0051785 positive regulation of nuclear division GO:0051983 regulation of chromosome segregation GO:0051984 positive regulation of chromosome segregation GO:0051985 negative regulation of chromosome segregation GO:0090068 positive regulation of cell cycle process GO:0098813 nuclear chromosome segregation GO:1901970 positive regulation of mitotic sister chromatid separation GO:1901987 regulation of cell cycle phase transition GO:1901989 positive regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901992 positive regulation of mitotic cell cycle phase transition GO:1902099 regulation of metaphase/anaphase transition of cell cycle GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle GO:1903046 meiotic cell cycle process GO:2001251 negative regulation of chromosome organization GO:2001252 positive regulation of chromosome organization |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004197 cysteine-type endopeptidase activity GO:0008234 cysteine-type peptidase activity |
Cellular Component |
GO:0005813 centrosome GO:0005819 spindle GO:0072686 mitotic spindle |
KEGG |
hsa04110 Cell cycle hsa04114 Oocyte meiosis |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-68886: M Phase R-HSA-68882: Mitotic Anaphase R-HSA-2555396: Mitotic Metaphase and Anaphase R-HSA-2467813: Separation of Sister Chromatids |
Summary | |
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Symbol | ESPL1 |
Name | extra spindle pole bodies like 1, separase |
Aliases | KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ESPL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ESPL1 |
Name | extra spindle pole bodies like 1, separase |
Aliases | KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ESPL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ESPL1 |
Name | extra spindle pole bodies like 1, separase |
Aliases | KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ESPL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ESPL1 in various data sets.
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Summary | |
---|---|
Symbol | ESPL1 |
Name | extra spindle pole bodies like 1, separase |
Aliases | KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ESPL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ESPL1 |
Name | extra spindle pole bodies like 1, separase |
Aliases | KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ESPL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ESPL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ESPL1 |
Name | extra spindle pole bodies like 1, separase |
Aliases | KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ESPL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ESPL1 |
Name | extra spindle pole bodies like 1, separase |
Aliases | KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ESPL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ESPL1 |
Name | extra spindle pole bodies like 1, separase |
Aliases | KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ESPL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ESPL1 |
Name | extra spindle pole bodies like 1, separase |
Aliases | KIAA0165; SEPA; separin; separase; separin, cysteine protease; extra spindle poles like 1 (S. cerevisiae); e ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ESPL1 collected from DrugBank database. |
There is no record. |