Summary | |
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Symbol | ESR1 |
Name | estrogen receptor 1 |
Aliases | NR3A1; Era; ESR; ESRA; ESTRR; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen recept ...... |
Chromosomal Location | 6q24-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Nucleus Cytoplasm Cell membrane Peripheral membrane protein Cytoplasmic side Note=A minor fraction is associated with the inner membrane.; SUBCELLULAR LOCATION: Isoform 3: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single-pass type I membrane protein. Note=Associated with the inner membrane via palmitoylation (Probable). At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. ; SUBCELLULAR LOCATION: Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated. |
Domain |
PF12743 Oestrogen-type nuclear receptor final C-terminal PF00104 Ligand-binding domain of nuclear hormone receptor PF02159 Oestrogen receptor PF00105 Zinc finger |
Function |
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1. |
Biological Process |
GO:0001541 ovarian follicle development GO:0001547 antral ovarian follicle growth GO:0001655 urogenital system development GO:0001763 morphogenesis of a branching structure GO:0002064 epithelial cell development GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0003401 axis elongation GO:0006338 chromatin remodeling GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006417 regulation of translation GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007548 sex differentiation GO:0007565 female pregnancy GO:0008209 androgen metabolic process GO:0008406 gonad development GO:0008584 male gonad development GO:0008585 female gonad development GO:0009755 hormone-mediated signaling pathway GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010608 posttranscriptional regulation of gene expression GO:0010817 regulation of hormone levels GO:0010863 positive regulation of phospholipase C activity GO:0016441 posttranscriptional gene silencing GO:0016458 gene silencing GO:0017148 negative regulation of translation GO:0022602 ovulation cycle process GO:0022612 gland morphogenesis GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030520 intracellular estrogen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0030540 female genitalia development GO:0030850 prostate gland development GO:0030879 mammary gland development GO:0031047 gene silencing by RNA GO:0031050 dsRNA fragmentation GO:0031349 positive regulation of defense response GO:0032355 response to estradiol GO:0033598 mammary gland epithelial cell proliferation GO:0034121 regulation of toll-like receptor signaling pathway GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0034502 protein localization to chromosome GO:0034754 cellular hormone metabolic process GO:0035194 posttranscriptional gene silencing by RNA GO:0035195 gene silencing by miRNA GO:0035196 production of miRNAs involved in gene silencing by miRNA GO:0035239 tube morphogenesis GO:0035265 organ growth GO:0040029 regulation of gene expression, epigenetic GO:0042445 hormone metabolic process GO:0042698 ovulation cycle GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043331 response to dsRNA GO:0043401 steroid hormone mediated signaling pathway GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043627 response to estrogen GO:0044706 multi-multicellular organism process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045137 development of primary sexual characteristics GO:0045727 positive regulation of translation GO:0046545 development of primary female sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046660 female sex differentiation GO:0046661 male sex differentiation GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048511 rhythmic process GO:0048545 response to steroid hormone GO:0048608 reproductive structure development GO:0048732 gland development GO:0048754 branching morphogenesis of an epithelial tube GO:0048806 genitalia development GO:0050673 epithelial cell proliferation GO:0050727 regulation of inflammatory response GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060065 uterus development GO:0060068 vagina development GO:0060135 maternal process involved in female pregnancy GO:0060147 regulation of posttranscriptional gene silencing GO:0060149 negative regulation of posttranscriptional gene silencing GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0060442 branching involved in prostate gland morphogenesis GO:0060443 mammary gland morphogenesis GO:0060444 branching involved in mammary gland duct morphogenesis GO:0060512 prostate gland morphogenesis GO:0060523 prostate epithelial cord elongation GO:0060525 prostate glandular acinus development GO:0060526 prostate glandular acinus morphogenesis GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060602 branch elongation of an epithelium GO:0060603 mammary gland duct morphogenesis GO:0060687 regulation of branching involved in prostate gland morphogenesis GO:0060688 regulation of morphogenesis of a branching structure GO:0060736 prostate gland growth GO:0060737 prostate gland morphogenetic growth GO:0060740 prostate gland epithelium morphogenesis GO:0060745 mammary gland branching involved in pregnancy GO:0060749 mammary gland alveolus development GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation GO:0060751 branch elongation involved in mammary gland duct branching GO:0060964 regulation of gene silencing by miRNA GO:0060965 negative regulation of gene silencing by miRNA GO:0060966 regulation of gene silencing by RNA GO:0060967 negative regulation of gene silencing by RNA GO:0060968 regulation of gene silencing GO:0060969 negative regulation of gene silencing GO:0061138 morphogenesis of a branching epithelium GO:0061180 mammary gland epithelium development GO:0061377 mammary gland lobule development GO:0061458 reproductive system development GO:0070918 production of small RNA involved in gene silencing by RNA GO:0070920 regulation of production of small RNA involved in gene silencing by RNA GO:0071168 protein localization to chromatin GO:0071359 cellular response to dsRNA GO:0071383 cellular response to steroid hormone stimulus GO:0071391 cellular response to estrogen stimulus GO:0071392 cellular response to estradiol stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:1900274 regulation of phospholipase C activity GO:1902532 negative regulation of intracellular signal transduction GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000241 regulation of reproductive process |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003707 steroid hormone receptor activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0005496 steroid binding GO:0008013 beta-catenin binding GO:0008134 transcription factor binding GO:0030235 nitric-oxide synthase regulator activity GO:0030284 estrogen receptor activity GO:0034056 estrogen response element binding GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0051117 ATPase binding GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0035327 transcriptionally active chromatin GO:0044454 nuclear chromosome part |
KEGG |
hsa04915 Estrogen signaling pathway hsa04917 Prolactin signaling pathway hsa04919 Thyroid hormone signaling pathway hsa04961 Endocrine and other factor-regulated calcium reabsorption |
Reactome |
R-HSA-5688426: Deubiquitination R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-392499: Metabolism of proteins R-HSA-383280: Nuclear Receptor transcription pathway R-HSA-1251985: Nuclear signaling by ERBB4 R-HSA-5689896: Ovarian tumor domain proteases R-HSA-597592: Post-translational protein modification R-HSA-162582: Signal Transduction R-HSA-1236394: Signaling by ERBB4 R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
Summary | |
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Symbol | ESR1 |
Name | estrogen receptor 1 |
Aliases | NR3A1; Era; ESR; ESRA; ESTRR; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen recept ...... |
Chromosomal Location | 6q24-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ESR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ESR1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ESR1 |
Name | estrogen receptor 1 |
Aliases | NR3A1; Era; ESR; ESRA; ESTRR; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen recept ...... |
Chromosomal Location | 6q24-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ESR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ESR1 |
Name | estrogen receptor 1 |
Aliases | NR3A1; Era; ESR; ESRA; ESTRR; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen recept ...... |
Chromosomal Location | 6q24-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ESR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ESR1 in various data sets.
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Summary | |
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Symbol | ESR1 |
Name | estrogen receptor 1 |
Aliases | NR3A1; Era; ESR; ESRA; ESTRR; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen recept ...... |
Chromosomal Location | 6q24-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ESR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ESR1 |
Name | estrogen receptor 1 |
Aliases | NR3A1; Era; ESR; ESRA; ESTRR; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen recept ...... |
Chromosomal Location | 6q24-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ESR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ESR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ESR1 |
Name | estrogen receptor 1 |
Aliases | NR3A1; Era; ESR; ESRA; ESTRR; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen recept ...... |
Chromosomal Location | 6q24-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ESR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ESR1 |
Name | estrogen receptor 1 |
Aliases | NR3A1; Era; ESR; ESRA; ESTRR; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen recept ...... |
Chromosomal Location | 6q24-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ESR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ESR1 |
Name | estrogen receptor 1 |
Aliases | NR3A1; Era; ESR; ESRA; ESTRR; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen recept ...... |
Chromosomal Location | 6q24-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ESR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ESR1 |
Name | estrogen receptor 1 |
Aliases | NR3A1; Era; ESR; ESRA; ESTRR; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen recept ...... |
Chromosomal Location | 6q24-q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ESR1 collected from DrugBank database. |
Details on drugs targeting ESR1.
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