Summary | |
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Symbol | ETNPPL |
Name | ethanolamine-phosphate phospho-lyase |
Aliases | AGXT2L1; alanine-glyoxylate aminotransferase 2-like 1; alanine--glyoxylate aminotransferase 2-like 1 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF00202 Aminotransferase class-III |
Function |
Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde. |
Biological Process |
GO:0006644 phospholipid metabolic process GO:0006646 phosphatidylethanolamine biosynthetic process GO:0006650 glycerophospholipid metabolic process GO:0008654 phospholipid biosynthetic process GO:0045017 glycerolipid biosynthetic process GO:0046337 phosphatidylethanolamine metabolic process GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process |
Molecular Function |
GO:0008483 transaminase activity GO:0016769 transferase activity, transferring nitrogenous groups GO:0016829 lyase activity GO:0016835 carbon-oxygen lyase activity GO:0016838 carbon-oxygen lyase activity, acting on phosphates GO:0030170 pyridoxal phosphate binding GO:0043168 anion binding GO:0048037 cofactor binding GO:0050459 ethanolamine-phosphate phospho-lyase activity |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG |
hsa00564 Glycerophospholipid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1483206: Glycerophospholipid biosynthesis R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1483257: Phospholipid metabolism R-HSA-1483213: Synthesis of PE |
Summary | |
---|---|
Symbol | ETNPPL |
Name | ethanolamine-phosphate phospho-lyase |
Aliases | AGXT2L1; alanine-glyoxylate aminotransferase 2-like 1; alanine--glyoxylate aminotransferase 2-like 1 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ETNPPL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ETNPPL |
Name | ethanolamine-phosphate phospho-lyase |
Aliases | AGXT2L1; alanine-glyoxylate aminotransferase 2-like 1; alanine--glyoxylate aminotransferase 2-like 1 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ETNPPL in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ETNPPL |
Name | ethanolamine-phosphate phospho-lyase |
Aliases | AGXT2L1; alanine-glyoxylate aminotransferase 2-like 1; alanine--glyoxylate aminotransferase 2-like 1 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ETNPPL in various data sets.
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Points in the above scatter plot represent the mutation difference of ETNPPL in various data sets.
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Summary | |
---|---|
Symbol | ETNPPL |
Name | ethanolamine-phosphate phospho-lyase |
Aliases | AGXT2L1; alanine-glyoxylate aminotransferase 2-like 1; alanine--glyoxylate aminotransferase 2-like 1 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ETNPPL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ETNPPL |
Name | ethanolamine-phosphate phospho-lyase |
Aliases | AGXT2L1; alanine-glyoxylate aminotransferase 2-like 1; alanine--glyoxylate aminotransferase 2-like 1 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ETNPPL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ETNPPL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ETNPPL |
Name | ethanolamine-phosphate phospho-lyase |
Aliases | AGXT2L1; alanine-glyoxylate aminotransferase 2-like 1; alanine--glyoxylate aminotransferase 2-like 1 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ETNPPL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ETNPPL |
Name | ethanolamine-phosphate phospho-lyase |
Aliases | AGXT2L1; alanine-glyoxylate aminotransferase 2-like 1; alanine--glyoxylate aminotransferase 2-like 1 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ETNPPL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ETNPPL |
Name | ethanolamine-phosphate phospho-lyase |
Aliases | AGXT2L1; alanine-glyoxylate aminotransferase 2-like 1; alanine--glyoxylate aminotransferase 2-like 1 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ETNPPL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ETNPPL |
Name | ethanolamine-phosphate phospho-lyase |
Aliases | AGXT2L1; alanine-glyoxylate aminotransferase 2-like 1; alanine--glyoxylate aminotransferase 2-like 1 |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ETNPPL collected from DrugBank database. |
There is no record. |