Summary | |
---|---|
Symbol | EVPL |
Name | envoplakin |
Aliases | EVPK; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, desmosome. Cornified envelope. Cytoplasm, cytoskeleton. Note=Colocalized with DSP at desmosomes and along intermediate filaments. |
Domain |
PF00681 Plectin repeat |
Function |
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. |
Biological Process |
GO:0008544 epidermis development GO:0009913 epidermal cell differentiation GO:0018149 peptide cross-linking GO:0030216 keratinocyte differentiation GO:0031424 keratinization GO:0043588 skin development |
Molecular Function |
GO:0019215 intermediate filament binding GO:0030674 protein binding, bridging GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0060090 binding, bridging GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0001533 cornified envelope GO:0005913 cell-cell adherens junction GO:0030057 desmosome GO:0045111 intermediate filament cytoskeleton |
KEGG | - |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-6809371: Formation of the cornified envelope R-HSA-6805567: Keratinization |
Summary | |
---|---|
Symbol | EVPL |
Name | envoplakin |
Aliases | EVPK; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EVPL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EVPL |
Name | envoplakin |
Aliases | EVPK; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EVPL in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | EVPL |
Name | envoplakin |
Aliases | EVPK; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EVPL in various data sets.
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Points in the above scatter plot represent the mutation difference of EVPL in various data sets.
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Summary | |
---|---|
Symbol | EVPL |
Name | envoplakin |
Aliases | EVPK; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EVPL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | EVPL |
Name | envoplakin |
Aliases | EVPK; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EVPL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EVPL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | EVPL |
Name | envoplakin |
Aliases | EVPK; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EVPL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | EVPL |
Name | envoplakin |
Aliases | EVPK; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EVPL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EVPL |
Name | envoplakin |
Aliases | EVPK; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EVPL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | EVPL |
Name | envoplakin |
Aliases | EVPK; 210 kDa cornified envelope precursor protein; 210 kDa paraneoplastic pemphigus antigen; p210 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EVPL collected from DrugBank database. |
There is no record. |