Summary | |
---|---|
Symbol | EXOC3L4 |
Name | exocyst complex component 3-like 4 |
Aliases | C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ...... |
Chromosomal Location | 14q32.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF06046 Exocyst complex component Sec6 |
Function |
- |
Biological Process |
GO:0006887 exocytosis GO:0031503 protein complex localization GO:0034629 cellular protein complex localization GO:0051601 exocyst localization |
Molecular Function |
GO:0000149 SNARE binding |
Cellular Component |
GO:0000145 exocyst GO:0005938 cell cortex GO:0044448 cell cortex part GO:0099023 tethring complex GO:0099568 cytoplasmic region |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | EXOC3L4 |
Name | exocyst complex component 3-like 4 |
Aliases | C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ...... |
Chromosomal Location | 14q32.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between EXOC3L4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | EXOC3L4 |
Name | exocyst complex component 3-like 4 |
Aliases | C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ...... |
Chromosomal Location | 14q32.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of EXOC3L4 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | EXOC3L4 |
Name | exocyst complex component 3-like 4 |
Aliases | C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ...... |
Chromosomal Location | 14q32.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of EXOC3L4 in various data sets.
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Points in the above scatter plot represent the mutation difference of EXOC3L4 in various data sets.
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Summary | |
---|---|
Symbol | EXOC3L4 |
Name | exocyst complex component 3-like 4 |
Aliases | C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ...... |
Chromosomal Location | 14q32.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of EXOC3L4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | EXOC3L4 |
Name | exocyst complex component 3-like 4 |
Aliases | C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ...... |
Chromosomal Location | 14q32.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of EXOC3L4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by EXOC3L4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | EXOC3L4 |
Name | exocyst complex component 3-like 4 |
Aliases | C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ...... |
Chromosomal Location | 14q32.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of EXOC3L4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | EXOC3L4 |
Name | exocyst complex component 3-like 4 |
Aliases | C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ...... |
Chromosomal Location | 14q32.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of EXOC3L4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | EXOC3L4 |
Name | exocyst complex component 3-like 4 |
Aliases | C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ...... |
Chromosomal Location | 14q32.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between EXOC3L4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | EXOC3L4 |
Name | exocyst complex component 3-like 4 |
Aliases | C14orf73; chromosome 14 open reading frame 73; SEC6-like protein C14orf73; Exocyst complex component 3-like ...... |
Chromosomal Location | 14q32.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting EXOC3L4 collected from DrugBank database. |
There is no record. |