Summary | |
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Symbol | F10 |
Name | coagulation factor X |
Aliases | FXA; Stuart-Prower factor; factor Xa; prothrombinase; Stuart factor |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00008 EGF-like domain PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain PF00089 Trypsin |
Function |
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. |
Biological Process |
GO:0006465 signal peptide processing GO:0006888 ER to Golgi vesicle-mediated transport GO:0007596 blood coagulation GO:0007597 blood coagulation, intrinsic pathway GO:0007598 blood coagulation, extrinsic pathway GO:0007599 hemostasis GO:0016485 protein processing GO:0017187 peptidyl-glutamic acid carboxylation GO:0018200 peptidyl-glutamic acid modification GO:0018214 protein carboxylation GO:0030335 positive regulation of cell migration GO:0040017 positive regulation of locomotion GO:0043491 protein kinase B signaling GO:0048193 Golgi vesicle transport GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051272 positive regulation of cellular component movement GO:0051604 protein maturation GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0072376 protein activation cascade GO:0072378 blood coagulation, fibrin clot formation GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0005543 phospholipid binding GO:0008236 serine-type peptidase activity GO:0017171 serine hydrolase activity |
Cellular Component |
GO:0005788 endoplasmic reticulum lumen GO:0005796 Golgi lumen GO:0009897 external side of plasma membrane GO:0031233 intrinsic component of external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04610 Complement and coagulation cascades |
Reactome |
R-HSA-140875: Common Pathway of Fibrin Clot Formation R-HSA-140834: Extrinsic Pathway of Fibrin Clot Formation R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade) R-HSA-163841: Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-159740: Gamma-carboxylation of protein precursors R-HSA-159854: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-109582: Hemostasis R-HSA-140837: Intrinsic Pathway of Fibrin Clot Formation R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus |
Summary | |
---|---|
Symbol | F10 |
Name | coagulation factor X |
Aliases | FXA; Stuart-Prower factor; factor Xa; prothrombinase; Stuart factor |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between F10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | F10 |
Name | coagulation factor X |
Aliases | FXA; Stuart-Prower factor; factor Xa; prothrombinase; Stuart factor |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of F10 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | F10 |
Name | coagulation factor X |
Aliases | FXA; Stuart-Prower factor; factor Xa; prothrombinase; Stuart factor |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of F10 in various data sets.
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Points in the above scatter plot represent the mutation difference of F10 in various data sets.
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Summary | |
---|---|
Symbol | F10 |
Name | coagulation factor X |
Aliases | FXA; Stuart-Prower factor; factor Xa; prothrombinase; Stuart factor |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of F10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | F10 |
Name | coagulation factor X |
Aliases | FXA; Stuart-Prower factor; factor Xa; prothrombinase; Stuart factor |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of F10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by F10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | F10 |
Name | coagulation factor X |
Aliases | FXA; Stuart-Prower factor; factor Xa; prothrombinase; Stuart factor |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of F10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | F10 |
Name | coagulation factor X |
Aliases | FXA; Stuart-Prower factor; factor Xa; prothrombinase; Stuart factor |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of F10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | F10 |
Name | coagulation factor X |
Aliases | FXA; Stuart-Prower factor; factor Xa; prothrombinase; Stuart factor |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between F10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | F10 |
Name | coagulation factor X |
Aliases | FXA; Stuart-Prower factor; factor Xa; prothrombinase; Stuart factor |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting F10 collected from DrugBank database. |
Details on drugs targeting F10.
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