Summary | |
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Symbol | F11R |
Name | F11 receptor |
Aliases | PAM-1; JCAM; JAM-1; JAM-A; JAMA; CD321; JAM1; junctional adhesion molecule 1; JAM; platelet F11 receptor; pl ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, tight junction Cell membrane Single-pass type I membrane protein Note=Localized at tight junctions of both epithelial and endothelial cells. |
Domain |
PF07686 Immunoglobulin V-set domain |
Function |
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). ; FUNCTION: (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. ; FUNCTION: (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. |
Biological Process |
GO:0001885 endothelial cell development GO:0002064 epithelial cell development GO:0003013 circulatory system process GO:0003158 endothelium development GO:0007009 plasma membrane organization GO:0007043 cell-cell junction assembly GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007586 digestion GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0009314 response to radiation GO:0019058 viral life cycle GO:0022600 digestive system process GO:0030198 extracellular matrix organization GO:0030260 entry into host cell GO:0031032 actomyosin structure organization GO:0031532 actin cytoskeleton reorganization GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0034260 negative regulation of GTPase activity GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0043062 extracellular structure organization GO:0043297 apical junction assembly GO:0044409 entry into host GO:0045216 cell-cell junction organization GO:0045446 endothelial cell differentiation GO:0045777 positive regulation of blood pressure GO:0046718 viral entry into host cell GO:0050892 intestinal absorption GO:0050900 leukocyte migration GO:0051346 negative regulation of hydrolase activity GO:0051493 regulation of cytoskeleton organization GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0061028 establishment of endothelial barrier GO:0070830 bicellular tight junction assembly GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:0090557 establishment of endothelial intestinal barrier GO:0090559 regulation of membrane permeability GO:1990778 protein localization to cell periphery GO:2000249 regulation of actin cytoskeleton reorganization |
Molecular Function |
GO:0001618 virus receptor activity GO:0030165 PDZ domain binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0005923 bicellular tight junction GO:0036056 filtration diaphragm GO:0036057 slit diaphragm GO:0043296 apical junction complex GO:0070160 occluding junction |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) hsa04530 Tight junction hsa04670 Leukocyte transendothelial migration |
Reactome |
R-HSA-446728: Cell junction organization R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1500931: Cell-Cell communication R-HSA-421270: Cell-cell junction organization R-HSA-1474244: Extracellular matrix organization R-HSA-109582: Hemostasis R-HSA-216083: Integrin cell surface interactions R-HSA-162582: Signal Transduction R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-420029: Tight junction interactions |
Summary | |
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Symbol | F11R |
Name | F11 receptor |
Aliases | PAM-1; JCAM; JAM-1; JAM-A; JAMA; CD321; JAM1; junctional adhesion molecule 1; JAM; platelet F11 receptor; pl ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between F11R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between F11R and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | F11R |
Name | F11 receptor |
Aliases | PAM-1; JCAM; JAM-1; JAM-A; JAMA; CD321; JAM1; junctional adhesion molecule 1; JAM; platelet F11 receptor; pl ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of F11R in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | F11R |
Name | F11 receptor |
Aliases | PAM-1; JCAM; JAM-1; JAM-A; JAMA; CD321; JAM1; junctional adhesion molecule 1; JAM; platelet F11 receptor; pl ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of F11R in various data sets.
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Points in the above scatter plot represent the mutation difference of F11R in various data sets.
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Summary | |
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Symbol | F11R |
Name | F11 receptor |
Aliases | PAM-1; JCAM; JAM-1; JAM-A; JAMA; CD321; JAM1; junctional adhesion molecule 1; JAM; platelet F11 receptor; pl ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of F11R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | F11R |
Name | F11 receptor |
Aliases | PAM-1; JCAM; JAM-1; JAM-A; JAMA; CD321; JAM1; junctional adhesion molecule 1; JAM; platelet F11 receptor; pl ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of F11R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by F11R. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | F11R |
Name | F11 receptor |
Aliases | PAM-1; JCAM; JAM-1; JAM-A; JAMA; CD321; JAM1; junctional adhesion molecule 1; JAM; platelet F11 receptor; pl ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of F11R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | F11R |
Name | F11 receptor |
Aliases | PAM-1; JCAM; JAM-1; JAM-A; JAMA; CD321; JAM1; junctional adhesion molecule 1; JAM; platelet F11 receptor; pl ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of F11R expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | F11R |
Name | F11 receptor |
Aliases | PAM-1; JCAM; JAM-1; JAM-A; JAMA; CD321; JAM1; junctional adhesion molecule 1; JAM; platelet F11 receptor; pl ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between F11R and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | F11R |
Name | F11 receptor |
Aliases | PAM-1; JCAM; JAM-1; JAM-A; JAMA; CD321; JAM1; junctional adhesion molecule 1; JAM; platelet F11 receptor; pl ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting F11R collected from DrugBank database. |
There is no record. |