Summary | |
---|---|
Symbol | F2RL1 |
Name | coagulation factor II (thrombin) receptor-like 1 |
Aliases | proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. |
Biological Process |
GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001885 endothelial cell development GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO:0001933 negative regulation of protein phosphorylation GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001960 negative regulation of cytokine-mediated signaling pathway GO:0001977 renal system process involved in regulation of blood volume GO:0001990 regulation of systemic arterial blood pressure by hormone GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001999 renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure GO:0002001 renin secretion into blood stream GO:0002064 epithelial cell development GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002278 eosinophil activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002367 cytokine production involved in immune response GO:0002374 cytokine secretion involved in immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002444 myeloid leukocyte mediated immunity GO:0002446 neutrophil mediated immunity GO:0002447 eosinophil mediated immunity GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002718 regulation of cytokine production involved in immune response GO:0002720 positive regulation of cytokine production involved in immune response GO:0002739 regulation of cytokine secretion involved in immune response GO:0002741 positive regulation of cytokine secretion involved in immune response GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002831 regulation of response to biotic stimulus GO:0002833 positive regulation of response to biotic stimulus GO:0002886 regulation of myeloid leukocyte mediated immunity GO:0002888 positive regulation of myeloid leukocyte mediated immunity GO:0003013 circulatory system process GO:0003014 renal system process GO:0003018 vascular process in circulatory system GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003071 renal system process involved in regulation of systemic arterial blood pressure GO:0003073 regulation of systemic arterial blood pressure GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003093 regulation of glomerular filtration GO:0003094 glomerular filtration GO:0003104 positive regulation of glomerular filtration GO:0003158 endothelium development GO:0006801 superoxide metabolic process GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006887 exocytosis GO:0006909 phagocytosis GO:0006911 phagocytosis, engulfment GO:0007015 actin filament organization GO:0007159 leukocyte cell-cell adhesion GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007254 JNK cascade GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0008217 regulation of blood pressure GO:0009306 protein secretion GO:0009615 response to virus GO:0010324 membrane invagination GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0017157 regulation of exocytosis GO:0030031 cell projection assembly GO:0030042 actin filament depolymerization GO:0030099 myeloid cell differentiation GO:0030100 regulation of endocytosis GO:0030193 regulation of blood coagulation GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0030832 regulation of actin filament length GO:0030834 regulation of actin filament depolymerization GO:0030836 positive regulation of actin filament depolymerization GO:0031098 stress-activated protein kinase signaling cascade GO:0031268 pseudopodium organization GO:0031269 pseudopodium assembly GO:0031272 regulation of pseudopodium assembly GO:0031274 positive regulation of pseudopodium assembly GO:0031341 regulation of cell killing GO:0031343 positive regulation of cell killing GO:0031346 positive regulation of cell projection organization GO:0031349 positive regulation of defense response GO:0031640 killing of cells of other organism GO:0032103 positive regulation of response to external stimulus GO:0032535 regulation of cellular component size GO:0032602 chemokine production GO:0032609 interferon-gamma production GO:0032611 interleukin-1 beta production GO:0032612 interleukin-1 production GO:0032613 interleukin-10 production GO:0032635 interleukin-6 production GO:0032637 interleukin-8 production GO:0032642 regulation of chemokine production GO:0032675 regulation of interleukin-6 production GO:0032677 regulation of interleukin-8 production GO:0032682 negative regulation of chemokine production GO:0032755 positive regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:0032872 regulation of stress-activated MAPK cascade GO:0032873 negative regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0032928 regulation of superoxide anion generation GO:0032930 positive regulation of superoxide anion generation GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0032984 macromolecular complex disassembly GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034121 regulation of toll-like receptor signaling pathway GO:0034122 negative regulation of toll-like receptor signaling pathway GO:0034123 positive regulation of toll-like receptor signaling pathway GO:0034134 toll-like receptor 2 signaling pathway GO:0034135 regulation of toll-like receptor 2 signaling pathway GO:0034137 positive regulation of toll-like receptor 2 signaling pathway GO:0034138 toll-like receptor 3 signaling pathway GO:0034139 regulation of toll-like receptor 3 signaling pathway GO:0034140 negative regulation of toll-like receptor 3 signaling pathway GO:0034141 positive regulation of toll-like receptor 3 signaling pathway GO:0034142 toll-like receptor 4 signaling pathway GO:0034143 regulation of toll-like receptor 4 signaling pathway GO:0034145 positive regulation of toll-like receptor 4 signaling pathway GO:0034612 response to tumor necrosis factor GO:0035023 regulation of Rho protein signal transduction GO:0035025 positive regulation of Rho protein signal transduction GO:0035150 regulation of tube size GO:0035821 modification of morphology or physiology of other organism GO:0035926 chemokine (C-C motif) ligand 2 secretion GO:0036230 granulocyte activation GO:0040017 positive regulation of locomotion GO:0042110 T cell activation GO:0042119 neutrophil activation GO:0042311 vasodilation GO:0042312 regulation of vasodilation GO:0042326 negative regulation of phosphorylation GO:0042554 superoxide anion generation GO:0042742 defense response to bacterium GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043241 protein complex disassembly GO:0043243 positive regulation of protein complex disassembly GO:0043244 regulation of protein complex disassembly GO:0043299 leukocyte degranulation GO:0043300 regulation of leukocyte degranulation GO:0043302 positive regulation of leukocyte degranulation GO:0043307 eosinophil activation GO:0043308 eosinophil degranulation GO:0043309 regulation of eosinophil degranulation GO:0043311 positive regulation of eosinophil degranulation GO:0043409 negative regulation of MAPK cascade GO:0043410 positive regulation of MAPK cascade GO:0043624 cellular protein complex disassembly GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044057 regulation of system process GO:0044060 regulation of endocrine process GO:0044089 positive regulation of cellular component biogenesis GO:0044364 disruption of cells of other organism GO:0045055 regulated exocytosis GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045446 endothelial cell differentiation GO:0045807 positive regulation of endocytosis GO:0045909 positive regulation of vasodilation GO:0045921 positive regulation of exocytosis GO:0046328 regulation of JNK cascade GO:0046329 negative regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046578 regulation of Ras protein signal transduction GO:0046579 positive regulation of Ras protein signal transduction GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0050663 cytokine secretion GO:0050701 interleukin-1 secretion GO:0050702 interleukin-1 beta secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050710 negative regulation of cytokine secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050829 defense response to Gram-negative bacterium GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050878 regulation of body fluid levels GO:0050880 regulation of blood vessel size GO:0050886 endocrine process GO:0050900 leukocyte migration GO:0050918 positive chemotaxis GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0050926 regulation of positive chemotaxis GO:0050927 positive regulation of positive chemotaxis GO:0051047 positive regulation of secretion GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051056 regulation of small GTPase mediated signal transduction GO:0051057 positive regulation of small GTPase mediated signal transduction GO:0051222 positive regulation of protein transport GO:0051224 negative regulation of protein transport GO:0051261 protein depolymerization GO:0051272 positive regulation of cellular component movement GO:0051403 stress-activated MAPK cascade GO:0051480 regulation of cytosolic calcium ion concentration GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051607 defense response to virus GO:0051702 interaction with symbiont GO:0051709 regulation of killing of cells of other organism GO:0051712 positive regulation of killing of cells of other organism GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051818 disruption of cells of other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0051852 disruption by host of symbiont cells GO:0051873 killing by host of symbiont cells GO:0051883 killing of cells in other organism involved in symbiotic interaction GO:0055074 calcium ion homeostasis GO:0060099 regulation of phagocytosis, engulfment GO:0060100 positive regulation of phagocytosis, engulfment GO:0060326 cell chemotaxis GO:0060491 regulation of cell projection assembly GO:0060627 regulation of vesicle-mediated transport GO:0060759 regulation of response to cytokine stimulus GO:0060761 negative regulation of response to cytokine stimulus GO:0061028 establishment of endothelial barrier GO:0061041 regulation of wound healing GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070493 thrombin receptor signaling pathway GO:0070661 leukocyte proliferation GO:0070942 neutrophil mediated cytotoxicity GO:0070943 neutrophil mediated killing of symbiont cell GO:0070944 neutrophil mediated killing of bacterium GO:0070945 neutrophil mediated killing of gram-negative bacterium GO:0070948 regulation of neutrophil mediated cytotoxicity GO:0070949 regulation of neutrophil mediated killing of symbiont cell GO:0070950 regulation of neutrophil mediated killing of bacterium GO:0070951 regulation of neutrophil mediated killing of gram-negative bacterium GO:0070960 positive regulation of neutrophil mediated cytotoxicity GO:0070961 positive regulation of neutrophil mediated killing of symbiont cell GO:0070962 positive regulation of neutrophil mediated killing of bacterium GO:0070963 positive regulation of neutrophil mediated killing of gram-negative bacterium GO:0071356 cellular response to tumor necrosis factor GO:0071593 lymphocyte aggregation GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072567 chemokine (C-X-C motif) ligand 2 production GO:0072593 reactive oxygen species metabolic process GO:0072604 interleukin-6 secretion GO:0072606 interleukin-8 secretion GO:0072608 interleukin-10 secretion GO:0072643 interferon-gamma secretion GO:0090066 regulation of anatomical structure size GO:0090195 chemokine secretion GO:0090196 regulation of chemokine secretion GO:0090198 negative regulation of chemokine secretion GO:0090322 regulation of superoxide metabolic process GO:0097028 dendritic cell differentiation GO:0097029 mature conventional dendritic cell differentiation GO:0097205 renal filtration GO:0098542 defense response to other organism GO:0098801 regulation of renal system process GO:0099024 plasma membrane invagination GO:1900046 regulation of hemostasis GO:1900133 regulation of renin secretion into blood stream GO:1900135 positive regulation of renin secretion into blood stream GO:1900424 regulation of defense response to bacterium GO:1900426 positive regulation of defense response to bacterium GO:1901879 regulation of protein depolymerization GO:1901881 positive regulation of protein depolymerization GO:1902532 negative regulation of intracellular signal transduction GO:1902566 regulation of eosinophil activation GO:1902568 positive regulation of eosinophil activation GO:1903034 regulation of response to wounding GO:1903305 regulation of regulated secretory pathway GO:1903307 positive regulation of regulated secretory pathway GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:1903531 negative regulation of secretion by cell GO:1903532 positive regulation of secretion by cell GO:1904950 negative regulation of establishment of protein localization GO:1904951 positive regulation of establishment of protein localization GO:1905153 regulation of membrane invagination GO:1905155 positive regulation of membrane invagination GO:2000147 positive regulation of cell motility GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000482 regulation of interleukin-8 secretion GO:2000484 positive regulation of interleukin-8 secretion GO:2000778 positive regulation of interleukin-6 secretion |
Molecular Function |
GO:0001653 peptide receptor activity GO:0001965 G-protein alpha-subunit binding GO:0008528 G-protein coupled peptide receptor activity GO:0015057 thrombin receptor activity GO:0031681 G-protein beta-subunit binding |
Cellular Component |
GO:0005769 early endosome GO:0031143 pseudopodium |
KEGG |
hsa04080 Neuroactive ligand-receptor interaction hsa04750 Inflammatory mediator regulation of TRP channels |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | F2RL1 |
Name | coagulation factor II (thrombin) receptor-like 1 |
Aliases | proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between F2RL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | F2RL1 |
Name | coagulation factor II (thrombin) receptor-like 1 |
Aliases | proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of F2RL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | F2RL1 |
Name | coagulation factor II (thrombin) receptor-like 1 |
Aliases | proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of F2RL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of F2RL1 in various data sets.
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Summary | |
---|---|
Symbol | F2RL1 |
Name | coagulation factor II (thrombin) receptor-like 1 |
Aliases | proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of F2RL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | F2RL1 |
Name | coagulation factor II (thrombin) receptor-like 1 |
Aliases | proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of F2RL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by F2RL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | F2RL1 |
Name | coagulation factor II (thrombin) receptor-like 1 |
Aliases | proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of F2RL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | F2RL1 |
Name | coagulation factor II (thrombin) receptor-like 1 |
Aliases | proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of F2RL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | F2RL1 |
Name | coagulation factor II (thrombin) receptor-like 1 |
Aliases | proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between F2RL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | F2RL1 |
Name | coagulation factor II (thrombin) receptor-like 1 |
Aliases | proteinase-activated receptor-2; GPR11; G-protein coupled receptor 11; coagulation factor II receptor-like 1 ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting F2RL1 collected from DrugBank database. |
There is no record. |