Browse F2RL3

Summary
SymbolF2RL3
Namecoagulation factor II (thrombin) receptor-like 3
Aliases proteinase-activated receptor-4; protease-activated receptor-4; thrombin receptor-like 3; Coagulation factor ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

> Gene Ontology
 
Biological Process GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010959 regulation of metal ion transport
GO:0016050 vesicle organization
GO:0030168 platelet activation
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0033363 secretory granule organization
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0043270 positive regulation of ion transport
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0055074 calcium ion homeostasis
GO:0060155 platelet dense granule organization
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0070493 thrombin receptor signaling pathway
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0090279 regulation of calcium ion import
GO:0090280 positive regulation of calcium ion import
GO:0097553 calcium ion transmembrane import into cytosol
GO:1902656 calcium ion import into cytosol
GO:1903169 regulation of calcium ion transmembrane transport
GO:1904062 regulation of cation transmembrane transport
GO:1904064 positive regulation of cation transmembrane transport
GO:1904427 positive regulation of calcium ion transmembrane transport
GO:2000021 regulation of ion homeostasis
Molecular Function GO:0001653 peptide receptor activity
GO:0008528 G-protein coupled peptide receptor activity
GO:0015057 thrombin receptor activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04015 Rap1 signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04610 Complement and coagulation cascades
hsa04611 Platelet activation
Reactome R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-109582: Hemostasis
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-456926: Thrombin signalling through proteinase activated receptors (PARs)
Summary
SymbolF2RL3
Namecoagulation factor II (thrombin) receptor-like 3
Aliases proteinase-activated receptor-4; protease-activated receptor-4; thrombin receptor-like 3; Coagulation factor ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between F2RL3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolF2RL3
Namecoagulation factor II (thrombin) receptor-like 3
Aliases proteinase-activated receptor-4; protease-activated receptor-4; thrombin receptor-like 3; Coagulation factor ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of F2RL3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolF2RL3
Namecoagulation factor II (thrombin) receptor-like 3
Aliases proteinase-activated receptor-4; protease-activated receptor-4; thrombin receptor-like 3; Coagulation factor ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of F2RL3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8830.0196
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.3820.0268
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5280.368
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2150.621
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3460.797
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0460.979
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3770.424
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2830.701
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.0630.161
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8940.185
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.510.0886
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3290.0789
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of F2RL3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolF2RL3
Namecoagulation factor II (thrombin) receptor-like 3
Aliases proteinase-activated receptor-4; protease-activated receptor-4; thrombin receptor-like 3; Coagulation factor ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of F2RL3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolF2RL3
Namecoagulation factor II (thrombin) receptor-like 3
Aliases proteinase-activated receptor-4; protease-activated receptor-4; thrombin receptor-like 3; Coagulation factor ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of F2RL3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by F2RL3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolF2RL3
Namecoagulation factor II (thrombin) receptor-like 3
Aliases proteinase-activated receptor-4; protease-activated receptor-4; thrombin receptor-like 3; Coagulation factor ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of F2RL3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolF2RL3
Namecoagulation factor II (thrombin) receptor-like 3
Aliases proteinase-activated receptor-4; protease-activated receptor-4; thrombin receptor-like 3; Coagulation factor ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of F2RL3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolF2RL3
Namecoagulation factor II (thrombin) receptor-like 3
Aliases proteinase-activated receptor-4; protease-activated receptor-4; thrombin receptor-like 3; Coagulation factor ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between F2RL3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolF2RL3
Namecoagulation factor II (thrombin) receptor-like 3
Aliases proteinase-activated receptor-4; protease-activated receptor-4; thrombin receptor-like 3; Coagulation factor ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting F2RL3 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting F2RL3.
ID Name Drug Type Targets #Targets
DB11300ThrombinSmall MoleculeF2R, F2RL32