Summary | |
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Symbol | F8 |
Name | coagulation factor VIII, procoagulant component |
Aliases | FVIII; DXS1253E; HEMA; Factor VIIIF8B; hemophilia A; F8C; AHF; DXS1253EB; antihemophilic factor; coagulation ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space. |
Domain |
PF00394 Multicopper oxidase PF07731 Multicopper oxidase PF07732 Multicopper oxidase PF00754 F5/8 type C domain |
Function |
Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa. |
Biological Process |
GO:0002526 acute inflammatory response GO:0002576 platelet degranulation GO:0006887 exocytosis GO:0006888 ER to Golgi vesicle-mediated transport GO:0006900 membrane budding GO:0006901 vesicle coating GO:0006903 vesicle targeting GO:0006953 acute-phase response GO:0007596 blood coagulation GO:0007597 blood coagulation, intrinsic pathway GO:0007599 hemostasis GO:0016050 vesicle organization GO:0030168 platelet activation GO:0045055 regulated exocytosis GO:0048193 Golgi vesicle transport GO:0048199 vesicle targeting, to, from or within Golgi GO:0048207 vesicle targeting, rough ER to cis-Golgi GO:0048208 COPII vesicle coating GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0072376 protein activation cascade GO:0072378 blood coagulation, fibrin clot formation GO:0090114 COPII-coated vesicle budding |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0005507 copper ion binding GO:0008236 serine-type peptidase activity GO:0017171 serine hydrolase activity |
Cellular Component |
GO:0005788 endoplasmic reticulum lumen GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030141 secretory granule GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0034774 secretory granule lumen GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0099503 secretory vesicle |
KEGG |
hsa04610 Complement and coagulation cascades |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-5694530: Cargo concentration in the ER R-HSA-140875: Common Pathway of Fibrin Clot Formation R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade) R-HSA-109582: Hemostasis R-HSA-140837: Intrinsic Pathway of Fibrin Clot Formation R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-597592: Post-translational protein modification R-HSA-76005: Response to elevated platelet cytosolic Ca2+ R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | F8 |
Name | coagulation factor VIII, procoagulant component |
Aliases | FVIII; DXS1253E; HEMA; Factor VIIIF8B; hemophilia A; F8C; AHF; DXS1253EB; antihemophilic factor; coagulation ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between F8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | F8 |
Name | coagulation factor VIII, procoagulant component |
Aliases | FVIII; DXS1253E; HEMA; Factor VIIIF8B; hemophilia A; F8C; AHF; DXS1253EB; antihemophilic factor; coagulation ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of F8 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | F8 |
Name | coagulation factor VIII, procoagulant component |
Aliases | FVIII; DXS1253E; HEMA; Factor VIIIF8B; hemophilia A; F8C; AHF; DXS1253EB; antihemophilic factor; coagulation ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of F8 in various data sets.
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Points in the above scatter plot represent the mutation difference of F8 in various data sets.
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Summary | |
---|---|
Symbol | F8 |
Name | coagulation factor VIII, procoagulant component |
Aliases | FVIII; DXS1253E; HEMA; Factor VIIIF8B; hemophilia A; F8C; AHF; DXS1253EB; antihemophilic factor; coagulation ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of F8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | F8 |
Name | coagulation factor VIII, procoagulant component |
Aliases | FVIII; DXS1253E; HEMA; Factor VIIIF8B; hemophilia A; F8C; AHF; DXS1253EB; antihemophilic factor; coagulation ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of F8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by F8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | F8 |
Name | coagulation factor VIII, procoagulant component |
Aliases | FVIII; DXS1253E; HEMA; Factor VIIIF8B; hemophilia A; F8C; AHF; DXS1253EB; antihemophilic factor; coagulation ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of F8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | F8 |
Name | coagulation factor VIII, procoagulant component |
Aliases | FVIII; DXS1253E; HEMA; Factor VIIIF8B; hemophilia A; F8C; AHF; DXS1253EB; antihemophilic factor; coagulation ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of F8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | F8 |
Name | coagulation factor VIII, procoagulant component |
Aliases | FVIII; DXS1253E; HEMA; Factor VIIIF8B; hemophilia A; F8C; AHF; DXS1253EB; antihemophilic factor; coagulation ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between F8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | F8 |
Name | coagulation factor VIII, procoagulant component |
Aliases | FVIII; DXS1253E; HEMA; Factor VIIIF8B; hemophilia A; F8C; AHF; DXS1253EB; antihemophilic factor; coagulation ...... |
Chromosomal Location | Xq28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting F8 collected from DrugBank database. |
Details on drugs targeting F8.
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