Summary | |
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Symbol | FAAH |
Name | fatty acid amide hydrolase |
Aliases | FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1 |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endomembrane system Single-pass membrane protein Cytoplasm, cytoskeleton Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network. |
Domain |
PF01425 Amidase |
Function |
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. |
Biological Process |
GO:0001676 long-chain fatty acid metabolic process GO:0006631 fatty acid metabolic process GO:0006690 icosanoid metabolic process GO:0009062 fatty acid catabolic process GO:0016042 lipid catabolic process GO:0016054 organic acid catabolic process GO:0019369 arachidonic acid metabolic process GO:0033559 unsaturated fatty acid metabolic process GO:0044242 cellular lipid catabolic process GO:0044282 small molecule catabolic process GO:0046395 carboxylic acid catabolic process GO:0072329 monocarboxylic acid catabolic process |
Molecular Function |
GO:0016298 lipase activity GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016874 ligase activity GO:0016879 ligase activity, forming carbon-nitrogen bonds GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GO:0017064 fatty acid amide hydrolase activity GO:0047372 acylglycerol lipase activity GO:0052689 carboxylic ester hydrolase activity GO:0103073 anandamide amidohydrolase activity |
Cellular Component | - |
KEGG |
hsa04723 Retrograde endocannabinoid signaling |
Reactome |
R-HSA-2142753: Arachidonic acid metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins |
Summary | |
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Symbol | FAAH |
Name | fatty acid amide hydrolase |
Aliases | FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1 |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FAAH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | FAAH |
Name | fatty acid amide hydrolase |
Aliases | FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1 |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FAAH in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FAAH |
Name | fatty acid amide hydrolase |
Aliases | FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1 |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FAAH in various data sets.
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Points in the above scatter plot represent the mutation difference of FAAH in various data sets.
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Summary | |
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Symbol | FAAH |
Name | fatty acid amide hydrolase |
Aliases | FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1 |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAAH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FAAH |
Name | fatty acid amide hydrolase |
Aliases | FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1 |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAAH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAAH. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FAAH |
Name | fatty acid amide hydrolase |
Aliases | FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1 |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAAH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FAAH |
Name | fatty acid amide hydrolase |
Aliases | FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1 |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FAAH expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FAAH |
Name | fatty acid amide hydrolase |
Aliases | FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1 |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FAAH and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FAAH |
Name | fatty acid amide hydrolase |
Aliases | FAAH-1; PSAB; anandamide amidohydrolase 1; oleamide hydrolase 1; Fatty-acid amide hydrolase 1 |
Chromosomal Location | 1p35-p34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FAAH collected from DrugBank database. |
Details on drugs targeting FAAH.
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