Summary | |
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Symbol | FABP1 |
Name | fatty acid binding protein 1, liver |
Aliases | L-FABP; FABPL; fatty acid-binding protein 1; liver-type fatty acid-binding protein; Fatty acid-binding prote ...... |
Chromosomal Location | 2p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain | - |
Function |
Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity). |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0001666 response to hypoxia GO:0006631 fatty acid metabolic process GO:0006635 fatty acid beta-oxidation GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0006820 anion transport GO:0006869 lipid transport GO:0006979 response to oxidative stress GO:0007586 digestion GO:0009062 fatty acid catabolic process GO:0009636 response to toxic substance GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010035 response to inorganic substance GO:0010466 negative regulation of peptidase activity GO:0010565 regulation of cellular ketone metabolic process GO:0010876 lipid localization GO:0010951 negative regulation of endopeptidase activity GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0016042 lipid catabolic process GO:0016054 organic acid catabolic process GO:0019216 regulation of lipid metabolic process GO:0019217 regulation of fatty acid metabolic process GO:0019395 fatty acid oxidation GO:0019433 triglyceride catabolic process GO:0022600 digestive system process GO:0030258 lipid modification GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031998 regulation of fatty acid beta-oxidation GO:0032000 positive regulation of fatty acid beta-oxidation GO:0034440 lipid oxidation GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0042180 cellular ketone metabolic process GO:0042542 response to hydrogen peroxide GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0044242 cellular lipid catabolic process GO:0044282 small molecule catabolic process GO:0045834 positive regulation of lipid metabolic process GO:0045861 negative regulation of proteolysis GO:0045923 positive regulation of fatty acid metabolic process GO:0046320 regulation of fatty acid oxidation GO:0046321 positive regulation of fatty acid oxidation GO:0046395 carboxylic acid catabolic process GO:0046461 neutral lipid catabolic process GO:0046464 acylglycerol catabolic process GO:0046486 glycerolipid metabolic process GO:0046503 glycerolipid catabolic process GO:0046942 carboxylic acid transport GO:0050892 intestinal absorption GO:0050994 regulation of lipid catabolic process GO:0050996 positive regulation of lipid catabolic process GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0070301 cellular response to hydrogen peroxide GO:0070482 response to oxygen levels GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0072329 monocarboxylic acid catabolic process GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1990748 cellular detoxification GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0003682 chromatin binding GO:0005319 lipid transporter activity GO:0005324 long-chain fatty acid transporter activity GO:0005496 steroid binding GO:0005504 fatty acid binding GO:0005543 phospholipid binding GO:0008144 drug binding GO:0015245 fatty acid transporter activity GO:0016209 antioxidant activity GO:0031406 carboxylic acid binding GO:0032052 bile acid binding GO:0033293 monocarboxylic acid binding GO:0043168 anion binding |
Cellular Component |
GO:0005777 peroxisome GO:0005782 peroxisomal matrix GO:0005938 cell cortex GO:0031907 microbody lumen GO:0042579 microbody GO:0044438 microbody part GO:0044439 peroxisomal part GO:0044448 cell cortex part GO:0045177 apical part of cell GO:0045179 apical cortex GO:0099568 cytoplasmic region GO:0099738 cell cortex region |
KEGG |
hsa03320 PPAR signaling pathway hsa04975 Fat digestion and absorption |
Reactome |
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-163560: Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1989781: PPARA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
Summary | |
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Symbol | FABP1 |
Name | fatty acid binding protein 1, liver |
Aliases | L-FABP; FABPL; fatty acid-binding protein 1; liver-type fatty acid-binding protein; Fatty acid-binding prote ...... |
Chromosomal Location | 2p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FABP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FABP1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FABP1 |
Name | fatty acid binding protein 1, liver |
Aliases | L-FABP; FABPL; fatty acid-binding protein 1; liver-type fatty acid-binding protein; Fatty acid-binding prote ...... |
Chromosomal Location | 2p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FABP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FABP1 |
Name | fatty acid binding protein 1, liver |
Aliases | L-FABP; FABPL; fatty acid-binding protein 1; liver-type fatty acid-binding protein; Fatty acid-binding prote ...... |
Chromosomal Location | 2p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FABP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of FABP1 in various data sets.
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Summary | |
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Symbol | FABP1 |
Name | fatty acid binding protein 1, liver |
Aliases | L-FABP; FABPL; fatty acid-binding protein 1; liver-type fatty acid-binding protein; Fatty acid-binding prote ...... |
Chromosomal Location | 2p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FABP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FABP1 |
Name | fatty acid binding protein 1, liver |
Aliases | L-FABP; FABPL; fatty acid-binding protein 1; liver-type fatty acid-binding protein; Fatty acid-binding prote ...... |
Chromosomal Location | 2p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FABP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FABP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FABP1 |
Name | fatty acid binding protein 1, liver |
Aliases | L-FABP; FABPL; fatty acid-binding protein 1; liver-type fatty acid-binding protein; Fatty acid-binding prote ...... |
Chromosomal Location | 2p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FABP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FABP1 |
Name | fatty acid binding protein 1, liver |
Aliases | L-FABP; FABPL; fatty acid-binding protein 1; liver-type fatty acid-binding protein; Fatty acid-binding prote ...... |
Chromosomal Location | 2p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FABP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FABP1 |
Name | fatty acid binding protein 1, liver |
Aliases | L-FABP; FABPL; fatty acid-binding protein 1; liver-type fatty acid-binding protein; Fatty acid-binding prote ...... |
Chromosomal Location | 2p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FABP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FABP1 |
Name | fatty acid binding protein 1, liver |
Aliases | L-FABP; FABPL; fatty acid-binding protein 1; liver-type fatty acid-binding protein; Fatty acid-binding prote ...... |
Chromosomal Location | 2p11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FABP1 collected from DrugBank database. |
There is no record. |