Summary | |
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Symbol | FABP3 |
Name | fatty acid binding protein 3, muscle and heart |
Aliases | H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ...... |
Chromosomal Location | 1p33-p32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF00061 Lipocalin / cytosolic fatty-acid binding protein family |
Function |
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. |
Biological Process |
GO:0001101 response to acid chemical GO:0006631 fatty acid metabolic process GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0006644 phospholipid metabolic process GO:0006820 anion transport GO:0006869 lipid transport GO:0008654 phospholipid biosynthetic process GO:0010565 regulation of cellular ketone metabolic process GO:0010876 lipid localization GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015849 organic acid transport GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0016042 lipid catabolic process GO:0019216 regulation of lipid metabolic process GO:0019217 regulation of fatty acid metabolic process GO:0019395 fatty acid oxidation GO:0019433 triglyceride catabolic process GO:0030258 lipid modification GO:0032868 response to insulin GO:0034440 lipid oxidation GO:0042180 cellular ketone metabolic process GO:0042493 response to drug GO:0042632 cholesterol homeostasis GO:0043434 response to peptide hormone GO:0044242 cellular lipid catabolic process GO:0044539 long-chain fatty acid import GO:0045834 positive regulation of lipid metabolic process GO:0046320 regulation of fatty acid oxidation GO:0046461 neutral lipid catabolic process GO:0046464 acylglycerol catabolic process GO:0046486 glycerolipid metabolic process GO:0046503 glycerolipid catabolic process GO:0046889 positive regulation of lipid biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0046942 carboxylic acid transport GO:0055088 lipid homeostasis GO:0055091 phospholipid homeostasis GO:0055092 sterol homeostasis GO:0070542 response to fatty acid GO:0071071 regulation of phospholipid biosynthetic process GO:0071073 positive regulation of phospholipid biosynthetic process GO:1901652 response to peptide GO:1903725 regulation of phospholipid metabolic process GO:1903727 positive regulation of phospholipid metabolic process |
Molecular Function |
GO:0005319 lipid transporter activity GO:0005324 long-chain fatty acid transporter activity GO:0005504 fatty acid binding GO:0015245 fatty acid transporter activity GO:0031406 carboxylic acid binding GO:0033293 monocarboxylic acid binding GO:0036041 long-chain fatty acid binding GO:0043168 anion binding GO:0050543 icosatetraenoic acid binding GO:0070538 oleic acid binding |
Cellular Component |
GO:0016528 sarcoplasm |
KEGG |
hsa03320 PPAR signaling pathway |
Reactome |
R-HSA-163560: Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins |
Summary | |
---|---|
Symbol | FABP3 |
Name | fatty acid binding protein 3, muscle and heart |
Aliases | H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ...... |
Chromosomal Location | 1p33-p32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FABP3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FABP3 |
Name | fatty acid binding protein 3, muscle and heart |
Aliases | H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ...... |
Chromosomal Location | 1p33-p32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FABP3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FABP3 |
Name | fatty acid binding protein 3, muscle and heart |
Aliases | H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ...... |
Chromosomal Location | 1p33-p32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FABP3 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | FABP3 |
Name | fatty acid binding protein 3, muscle and heart |
Aliases | H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ...... |
Chromosomal Location | 1p33-p32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FABP3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FABP3 |
Name | fatty acid binding protein 3, muscle and heart |
Aliases | H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ...... |
Chromosomal Location | 1p33-p32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FABP3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FABP3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FABP3 |
Name | fatty acid binding protein 3, muscle and heart |
Aliases | H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ...... |
Chromosomal Location | 1p33-p32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FABP3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FABP3 |
Name | fatty acid binding protein 3, muscle and heart |
Aliases | H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ...... |
Chromosomal Location | 1p33-p32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FABP3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FABP3 |
Name | fatty acid binding protein 3, muscle and heart |
Aliases | H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ...... |
Chromosomal Location | 1p33-p32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FABP3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FABP3 |
Name | fatty acid binding protein 3, muscle and heart |
Aliases | H-FABP; O-FABP; mammary-derived growth inhibitor; MDGI; FABP11; fatty acid binding protein 11; fatty acid bi ...... |
Chromosomal Location | 1p33-p32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FABP3 collected from DrugBank database. |
There is no record. |