Browse FAIM2

Summary
SymbolFAIM2
NameFas apoptotic inhibitory molecule 2
Aliases KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ......
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Membrane raft Cell junction, synapse, postsynaptic cell membrane
Domain PF01027 Inhibitor of apoptosis-promoting Bax1
Function

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.

> Gene Ontology
 
Biological Process GO:0002931 response to ischemia
GO:0021533 cell differentiation in hindbrain
GO:0021549 cerebellum development
GO:0021575 hindbrain morphogenesis
GO:0021587 cerebellum morphogenesis
GO:0021680 cerebellar Purkinje cell layer development
GO:0021681 cerebellar granular layer development
GO:0021692 cerebellar Purkinje cell layer morphogenesis
GO:0021694 cerebellar Purkinje cell layer formation
GO:0021695 cerebellar cortex development
GO:0021696 cerebellar cortex morphogenesis
GO:0021697 cerebellar cortex formation
GO:0021702 cerebellar Purkinje cell differentiation
GO:0021953 central nervous system neuron differentiation
GO:0022037 metencephalon development
GO:0030902 hindbrain development
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0051402 neuron apoptotic process
GO:0070997 neuron death
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
Molecular Function -
Cellular Component GO:0045121 membrane raft
GO:0045211 postsynaptic membrane
GO:0097060 synaptic membrane
GO:0098589 membrane region
GO:0098794 postsynapse
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolFAIM2
NameFas apoptotic inhibitory molecule 2
Aliases KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ......
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FAIM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolFAIM2
NameFas apoptotic inhibitory molecule 2
Aliases KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ......
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FAIM2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFAIM2
NameFas apoptotic inhibitory molecule 2
Aliases KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ......
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FAIM2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1950.503
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.7880.131
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2320.584
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.7790.243
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.3860.288
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.020.989
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1390.815
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6490.458
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4110.659
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.1080.0242
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3440.584
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0570.827
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FAIM2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.75.5-1.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.76.8-3.11
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFAIM2
NameFas apoptotic inhibitory molecule 2
Aliases KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ......
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAIM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFAIM2
NameFas apoptotic inhibitory molecule 2
Aliases KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ......
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAIM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAIM2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFAIM2
NameFas apoptotic inhibitory molecule 2
Aliases KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ......
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAIM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFAIM2
NameFas apoptotic inhibitory molecule 2
Aliases KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ......
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FAIM2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFAIM2
NameFas apoptotic inhibitory molecule 2
Aliases KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ......
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FAIM2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFAIM2
NameFas apoptotic inhibitory molecule 2
Aliases KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ......
Chromosomal Location12q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FAIM2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.