Summary | |
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Symbol | FAIM2 |
Name | Fas apoptotic inhibitory molecule 2 |
Aliases | KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Membrane raft Cell junction, synapse, postsynaptic cell membrane |
Domain |
PF01027 Inhibitor of apoptosis-promoting Bax1 |
Function |
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. |
Biological Process |
GO:0002931 response to ischemia GO:0021533 cell differentiation in hindbrain GO:0021549 cerebellum development GO:0021575 hindbrain morphogenesis GO:0021587 cerebellum morphogenesis GO:0021680 cerebellar Purkinje cell layer development GO:0021681 cerebellar granular layer development GO:0021692 cerebellar Purkinje cell layer morphogenesis GO:0021694 cerebellar Purkinje cell layer formation GO:0021695 cerebellar cortex development GO:0021696 cerebellar cortex morphogenesis GO:0021697 cerebellar cortex formation GO:0021702 cerebellar Purkinje cell differentiation GO:0021953 central nervous system neuron differentiation GO:0022037 metencephalon development GO:0030902 hindbrain development GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0051402 neuron apoptotic process GO:0070997 neuron death GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway |
Molecular Function | - |
Cellular Component |
GO:0045121 membrane raft GO:0045211 postsynaptic membrane GO:0097060 synaptic membrane GO:0098589 membrane region GO:0098794 postsynapse GO:0098857 membrane microdomain |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | FAIM2 |
Name | Fas apoptotic inhibitory molecule 2 |
Aliases | KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FAIM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FAIM2 |
Name | Fas apoptotic inhibitory molecule 2 |
Aliases | KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FAIM2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FAIM2 |
Name | Fas apoptotic inhibitory molecule 2 |
Aliases | KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FAIM2 in various data sets.
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Points in the above scatter plot represent the mutation difference of FAIM2 in various data sets.
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Summary | |
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Symbol | FAIM2 |
Name | Fas apoptotic inhibitory molecule 2 |
Aliases | KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAIM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FAIM2 |
Name | Fas apoptotic inhibitory molecule 2 |
Aliases | KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAIM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAIM2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FAIM2 |
Name | Fas apoptotic inhibitory molecule 2 |
Aliases | KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAIM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FAIM2 |
Name | Fas apoptotic inhibitory molecule 2 |
Aliases | KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FAIM2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FAIM2 |
Name | Fas apoptotic inhibitory molecule 2 |
Aliases | KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FAIM2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FAIM2 |
Name | Fas apoptotic inhibitory molecule 2 |
Aliases | KIAA0950; LFG; NMP35; LIFEGUARD; TMBIM2; LFG2; transmembrane BAX inhibitor motif containing 2; NGP35; neural ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FAIM2 collected from DrugBank database. |
There is no record. |