Summary | |
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Symbol | FAM101A |
Name | family with sequence similarity 101, member A |
Aliases | FLJ44614; protein FAM101A; refilinA; regulator of filamin protein A; Filamin-interacting protein FAM101A |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton Note=Colocalizes with FLNA along actin bundle-like structures. |
Domain |
PF15068 FAM101 family |
Function |
Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0002062 chondrocyte differentiation GO:0002063 chondrocyte development GO:0007015 actin filament organization GO:0010721 negative regulation of cell development GO:0021700 developmental maturation GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030282 bone mineralization GO:0030500 regulation of bone mineralization GO:0030502 negative regulation of bone mineralization GO:0031214 biomineral tissue development GO:0032330 regulation of chondrocyte differentiation GO:0032331 negative regulation of chondrocyte differentiation GO:0035630 bone mineralization involved in bone maturation GO:0043931 ossification involved in bone maturation GO:0048705 skeletal system morphogenesis GO:0048799 animal organ maturation GO:0051216 cartilage development GO:0060348 bone development GO:0061035 regulation of cartilage development GO:0061037 negative regulation of cartilage development GO:0061181 regulation of chondrocyte development GO:0061182 negative regulation of chondrocyte development GO:0061448 connective tissue development GO:0061572 actin filament bundle organization GO:0070167 regulation of biomineral tissue development GO:0070168 negative regulation of biomineral tissue development GO:0070977 bone maturation GO:0071695 anatomical structure maturation GO:1900157 regulation of bone mineralization involved in bone maturation GO:1900158 negative regulation of bone mineralization involved in bone maturation GO:1903010 regulation of bone development GO:1903011 negative regulation of bone development |
Molecular Function |
GO:0031005 filamin binding |
Cellular Component |
GO:0015629 actin cytoskeleton GO:0032432 actin filament bundle |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | FAM101A |
Name | family with sequence similarity 101, member A |
Aliases | FLJ44614; protein FAM101A; refilinA; regulator of filamin protein A; Filamin-interacting protein FAM101A |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FAM101A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FAM101A |
Name | family with sequence similarity 101, member A |
Aliases | FLJ44614; protein FAM101A; refilinA; regulator of filamin protein A; Filamin-interacting protein FAM101A |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FAM101A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FAM101A |
Name | family with sequence similarity 101, member A |
Aliases | FLJ44614; protein FAM101A; refilinA; regulator of filamin protein A; Filamin-interacting protein FAM101A |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FAM101A in various data sets.
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Points in the above scatter plot represent the mutation difference of FAM101A in various data sets.
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Summary | |
---|---|
Symbol | FAM101A |
Name | family with sequence similarity 101, member A |
Aliases | FLJ44614; protein FAM101A; refilinA; regulator of filamin protein A; Filamin-interacting protein FAM101A |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAM101A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FAM101A |
Name | family with sequence similarity 101, member A |
Aliases | FLJ44614; protein FAM101A; refilinA; regulator of filamin protein A; Filamin-interacting protein FAM101A |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAM101A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAM101A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FAM101A |
Name | family with sequence similarity 101, member A |
Aliases | FLJ44614; protein FAM101A; refilinA; regulator of filamin protein A; Filamin-interacting protein FAM101A |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAM101A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FAM101A |
Name | family with sequence similarity 101, member A |
Aliases | FLJ44614; protein FAM101A; refilinA; regulator of filamin protein A; Filamin-interacting protein FAM101A |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FAM101A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FAM101A |
Name | family with sequence similarity 101, member A |
Aliases | FLJ44614; protein FAM101A; refilinA; regulator of filamin protein A; Filamin-interacting protein FAM101A |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FAM101A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FAM101A |
Name | family with sequence similarity 101, member A |
Aliases | FLJ44614; protein FAM101A; refilinA; regulator of filamin protein A; Filamin-interacting protein FAM101A |
Chromosomal Location | 12q24.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FAM101A collected from DrugBank database. |
There is no record. |