Summary | |
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Symbol | FAM103A1 |
Name | family with sequence similarity 103, member A1 |
Aliases | HsT19360; C15orf18; MGC2560; RNMT-activating mini protein; protein FAM103A1 |
Chromosomal Location | 15q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF15320 mRNA cap methylation |
Function |
Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306). |
Biological Process |
GO:0006370 7-methylguanosine mRNA capping GO:0006397 mRNA processing GO:0009452 7-methylguanosine RNA capping GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0032259 methylation GO:0036031 recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex GO:0036260 RNA capping GO:0071826 ribonucleoprotein complex subunit organization |
Molecular Function | - |
Cellular Component |
GO:0005845 mRNA cap binding complex GO:0034518 RNA cap binding complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | FAM103A1 |
Name | family with sequence similarity 103, member A1 |
Aliases | HsT19360; C15orf18; MGC2560; RNMT-activating mini protein; protein FAM103A1 |
Chromosomal Location | 15q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FAM103A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FAM103A1 |
Name | family with sequence similarity 103, member A1 |
Aliases | HsT19360; C15orf18; MGC2560; RNMT-activating mini protein; protein FAM103A1 |
Chromosomal Location | 15q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FAM103A1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FAM103A1 |
Name | family with sequence similarity 103, member A1 |
Aliases | HsT19360; C15orf18; MGC2560; RNMT-activating mini protein; protein FAM103A1 |
Chromosomal Location | 15q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FAM103A1 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | FAM103A1 |
Name | family with sequence similarity 103, member A1 |
Aliases | HsT19360; C15orf18; MGC2560; RNMT-activating mini protein; protein FAM103A1 |
Chromosomal Location | 15q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAM103A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FAM103A1 |
Name | family with sequence similarity 103, member A1 |
Aliases | HsT19360; C15orf18; MGC2560; RNMT-activating mini protein; protein FAM103A1 |
Chromosomal Location | 15q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAM103A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAM103A1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FAM103A1 |
Name | family with sequence similarity 103, member A1 |
Aliases | HsT19360; C15orf18; MGC2560; RNMT-activating mini protein; protein FAM103A1 |
Chromosomal Location | 15q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAM103A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FAM103A1 |
Name | family with sequence similarity 103, member A1 |
Aliases | HsT19360; C15orf18; MGC2560; RNMT-activating mini protein; protein FAM103A1 |
Chromosomal Location | 15q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FAM103A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FAM103A1 |
Name | family with sequence similarity 103, member A1 |
Aliases | HsT19360; C15orf18; MGC2560; RNMT-activating mini protein; protein FAM103A1 |
Chromosomal Location | 15q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FAM103A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FAM103A1 |
Name | family with sequence similarity 103, member A1 |
Aliases | HsT19360; C15orf18; MGC2560; RNMT-activating mini protein; protein FAM103A1 |
Chromosomal Location | 15q25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FAM103A1 collected from DrugBank database. |
There is no record. |