Summary | |
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Symbol | FAM109B |
Name | family with sequence similarity 109, member B |
Aliases | DKFZp686J07229; IPIP27B; 27 kDa inositol polyphosphate phosphatase interacting protein B; Sesquipedalian-2 |
Chromosomal Location | 22q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes. |
Domain |
PF00169 PH domain |
Function |
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. |
Biological Process |
GO:0001881 receptor recycling GO:0007032 endosome organization GO:0007033 vacuole organization GO:0007034 vacuolar transport GO:0016197 endosomal transport GO:0016482 cytosolic transport GO:0042147 retrograde transport, endosome to Golgi GO:0043112 receptor metabolic process |
Molecular Function | - |
Cellular Component |
GO:0005769 early endosome GO:0005802 trans-Golgi network GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0031984 organelle subcompartment GO:0055037 recycling endosome GO:0098791 Golgi subcompartment |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | FAM109B |
Name | family with sequence similarity 109, member B |
Aliases | DKFZp686J07229; IPIP27B; 27 kDa inositol polyphosphate phosphatase interacting protein B; Sesquipedalian-2 |
Chromosomal Location | 22q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FAM109B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FAM109B |
Name | family with sequence similarity 109, member B |
Aliases | DKFZp686J07229; IPIP27B; 27 kDa inositol polyphosphate phosphatase interacting protein B; Sesquipedalian-2 |
Chromosomal Location | 22q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FAM109B in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | FAM109B |
Name | family with sequence similarity 109, member B |
Aliases | DKFZp686J07229; IPIP27B; 27 kDa inositol polyphosphate phosphatase interacting protein B; Sesquipedalian-2 |
Chromosomal Location | 22q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FAM109B in various data sets.
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Points in the above scatter plot represent the mutation difference of FAM109B in various data sets.
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Summary | |
---|---|
Symbol | FAM109B |
Name | family with sequence similarity 109, member B |
Aliases | DKFZp686J07229; IPIP27B; 27 kDa inositol polyphosphate phosphatase interacting protein B; Sesquipedalian-2 |
Chromosomal Location | 22q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAM109B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FAM109B |
Name | family with sequence similarity 109, member B |
Aliases | DKFZp686J07229; IPIP27B; 27 kDa inositol polyphosphate phosphatase interacting protein B; Sesquipedalian-2 |
Chromosomal Location | 22q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAM109B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAM109B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FAM109B |
Name | family with sequence similarity 109, member B |
Aliases | DKFZp686J07229; IPIP27B; 27 kDa inositol polyphosphate phosphatase interacting protein B; Sesquipedalian-2 |
Chromosomal Location | 22q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAM109B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FAM109B |
Name | family with sequence similarity 109, member B |
Aliases | DKFZp686J07229; IPIP27B; 27 kDa inositol polyphosphate phosphatase interacting protein B; Sesquipedalian-2 |
Chromosomal Location | 22q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FAM109B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FAM109B |
Name | family with sequence similarity 109, member B |
Aliases | DKFZp686J07229; IPIP27B; 27 kDa inositol polyphosphate phosphatase interacting protein B; Sesquipedalian-2 |
Chromosomal Location | 22q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FAM109B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FAM109B |
Name | family with sequence similarity 109, member B |
Aliases | DKFZp686J07229; IPIP27B; 27 kDa inositol polyphosphate phosphatase interacting protein B; Sesquipedalian-2 |
Chromosomal Location | 22q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FAM109B collected from DrugBank database. |
There is no record. |