Browse FAM126A

Summary
SymbolFAM126A
Namefamily with sequence similarity 126, member A
Aliases DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytosol Cell membrane Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex.
Domain PF09790 Hyccin
Function

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway (Probable).

> Gene Ontology
 
Biological Process GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0007009 plasma membrane organization
GO:0007272 ensheathment of neurons
GO:0008366 axon ensheathment
GO:0030258 lipid modification
GO:0042552 myelination
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090150 establishment of protein localization to membrane
GO:1990778 protein localization to cell periphery
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolFAM126A
Namefamily with sequence similarity 126, member A
Aliases DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FAM126A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolFAM126A
Namefamily with sequence similarity 126, member A
Aliases DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FAM126A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFAM126A
Namefamily with sequence similarity 126, member A
Aliases DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FAM126A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.120.696
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.260.876
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4020.76
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.0220.0278
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.5580.336
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3450.867
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2710.544
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4330.827
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2160.916
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1930.851
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.3990.287
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1420.24
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FAM126A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFAM126A
Namefamily with sequence similarity 126, member A
Aliases DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAM126A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFAM126A
Namefamily with sequence similarity 126, member A
Aliases DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAM126A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAM126A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFAM126A
Namefamily with sequence similarity 126, member A
Aliases DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAM126A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFAM126A
Namefamily with sequence similarity 126, member A
Aliases DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FAM126A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFAM126A
Namefamily with sequence similarity 126, member A
Aliases DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FAM126A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFAM126A
Namefamily with sequence similarity 126, member A
Aliases DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FAM126A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.