Summary | |
---|---|
Symbol | FAM126A |
Name | family with sequence similarity 126, member A |
Aliases | DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytosol Cell membrane Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with other components of the phosphatidylinositol 4-kinase (PI4K) complex. |
Domain |
PF09790 Hyccin |
Function |
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway (Probable). |
Biological Process |
GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0007009 plasma membrane organization GO:0007272 ensheathment of neurons GO:0008366 axon ensheathment GO:0030258 lipid modification GO:0042552 myelination GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:1990778 protein localization to cell periphery |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | FAM126A |
Name | family with sequence similarity 126, member A |
Aliases | DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FAM126A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FAM126A |
Name | family with sequence similarity 126, member A |
Aliases | DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of FAM126A in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | FAM126A |
Name | family with sequence similarity 126, member A |
Aliases | DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FAM126A in various data sets.
|
Points in the above scatter plot represent the mutation difference of FAM126A in various data sets.
|
Summary | |
---|---|
Symbol | FAM126A |
Name | family with sequence similarity 126, member A |
Aliases | DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAM126A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FAM126A |
Name | family with sequence similarity 126, member A |
Aliases | DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAM126A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAM126A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FAM126A |
Name | family with sequence similarity 126, member A |
Aliases | DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAM126A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FAM126A |
Name | family with sequence similarity 126, member A |
Aliases | DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FAM126A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FAM126A |
Name | family with sequence similarity 126, member A |
Aliases | DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FAM126A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FAM126A |
Name | family with sequence similarity 126, member A |
Aliases | DRCTNNB1A; HCC; HYCC1; hyccin; down regulated by Ctnnb1, a; HLD5; down-regulated by CTNNB1 protein A; Protei ...... |
Chromosomal Location | 7p15.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FAM126A collected from DrugBank database. |
There is no record. |