Summary | |
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Symbol | FAM73B |
Name | family with sequence similarity 73, member B |
Aliases | FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion outer membrane Multi-pass membrane protein |
Domain |
PF10265 Mitoguardin |
Function |
Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD. |
Biological Process |
GO:0001501 skeletal system development GO:0008053 mitochondrial fusion GO:0044801 single-organism membrane fusion GO:0048284 organelle fusion GO:0060348 bone development GO:0061025 membrane fusion |
Molecular Function |
GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0005741 mitochondrial outer membrane GO:0009279 cell outer membrane GO:0019867 outer membrane GO:0030312 external encapsulating structure GO:0030313 cell envelope GO:0031230 intrinsic component of cell outer membrane GO:0031968 organelle outer membrane GO:0044462 external encapsulating structure part GO:0045203 integral component of cell outer membrane |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | FAM73B |
Name | family with sequence similarity 73, member B |
Aliases | FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FAM73B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FAM73B and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FAM73B |
Name | family with sequence similarity 73, member B |
Aliases | FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FAM73B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FAM73B |
Name | family with sequence similarity 73, member B |
Aliases | FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FAM73B in various data sets.
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Points in the above scatter plot represent the mutation difference of FAM73B in various data sets.
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Summary | |
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Symbol | FAM73B |
Name | family with sequence similarity 73, member B |
Aliases | FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAM73B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FAM73B |
Name | family with sequence similarity 73, member B |
Aliases | FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAM73B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAM73B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FAM73B |
Name | family with sequence similarity 73, member B |
Aliases | FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAM73B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FAM73B |
Name | family with sequence similarity 73, member B |
Aliases | FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FAM73B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FAM73B |
Name | family with sequence similarity 73, member B |
Aliases | FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FAM73B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FAM73B |
Name | family with sequence similarity 73, member B |
Aliases | FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B |
Chromosomal Location | 9q34.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FAM73B collected from DrugBank database. |
There is no record. |