Browse FAM73B

Summary
SymbolFAM73B
Namefamily with sequence similarity 73, member B
Aliases FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion outer membrane Multi-pass membrane protein
Domain PF10265 Mitoguardin
Function

Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0008053 mitochondrial fusion
GO:0044801 single-organism membrane fusion
GO:0048284 organelle fusion
GO:0060348 bone development
GO:0061025 membrane fusion
Molecular Function GO:0046982 protein heterodimerization activity
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0009279 cell outer membrane
GO:0019867 outer membrane
GO:0030312 external encapsulating structure
GO:0030313 cell envelope
GO:0031230 intrinsic component of cell outer membrane
GO:0031968 organelle outer membrane
GO:0044462 external encapsulating structure part
GO:0045203 integral component of cell outer membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolFAM73B
Namefamily with sequence similarity 73, member B
Aliases FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FAM73B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between FAM73B and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29180626MelanomaInhibit immunityHere we show that FAM73b, a mitochondrial outer membrane protein, has a pivotal function in Toll-like receptor-regulated mitochondrial morphology switching from fusion to fission. Switching to mitochondrial fission via ablation of Fam73b (also known as Miga2) promotes IL-12 production. In tumor-associated macrophages, this switch results in T-cell activation and enhances anti-tumor immunity.
Summary
SymbolFAM73B
Namefamily with sequence similarity 73, member B
Aliases FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FAM73B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFAM73B
Namefamily with sequence similarity 73, member B
Aliases FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FAM73B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1730.513
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2650.837
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1120.914
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3790.306
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3970.841
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.360.891
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2630.391
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3980.723
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.120.923
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2890.805
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8050.582
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.090.299
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FAM73B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFAM73B
Namefamily with sequence similarity 73, member B
Aliases FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAM73B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFAM73B
Namefamily with sequence similarity 73, member B
Aliases FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAM73B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAM73B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFAM73B
Namefamily with sequence similarity 73, member B
Aliases FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAM73B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFAM73B
Namefamily with sequence similarity 73, member B
Aliases FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FAM73B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFAM73B
Namefamily with sequence similarity 73, member B
Aliases FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FAM73B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFAM73B
Namefamily with sequence similarity 73, member B
Aliases FLJ14596; FLJ00199; C9orf54; chromosome 9 open reading frame 54; Protein FAM73B
Chromosomal Location9q34.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FAM73B collected from DrugBank database.
> Drugs from DrugBank database
 

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