Summary | |
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Symbol | FANCM |
Name | Fanconi anemia, complementation group M |
Aliases | FAAP250; KIAA1596; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; prote ...... |
Chromosomal Location | 14q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF02732 ERCC4 domain PF16783 FANCM to MHF binding domain PF00271 Helicase conserved C-terminal domain PF04851 Type III restriction enzyme |
Function |
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). |
Biological Process |
GO:0000712 resolution of meiotic recombination intermediates GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006310 DNA recombination GO:0007059 chromosome segregation GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007131 reciprocal meiotic recombination GO:0031297 replication fork processing GO:0035825 reciprocal DNA recombination GO:0036297 interstrand cross-link repair GO:0045005 DNA-dependent DNA replication maintenance of fidelity GO:0045132 meiotic chromosome segregation GO:0051304 chromosome separation GO:0051307 meiotic chromosome separation GO:0051321 meiotic cell cycle GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0098813 nuclear chromosome segregation GO:1903046 meiotic cell cycle process |
Molecular Function |
GO:0003682 chromatin binding GO:0004386 helicase activity GO:0004518 nuclease activity |
Cellular Component |
GO:0043240 Fanconi anaemia nuclear complex GO:0071821 FANCM-MHF complex |
KEGG |
hsa03460 Fanconi anemia pathway |
Reactome |
R-HSA-73894: DNA Repair R-HSA-6783310: Fanconi Anemia Pathway |
Summary | |
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Symbol | FANCM |
Name | Fanconi anemia, complementation group M |
Aliases | FAAP250; KIAA1596; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; prote ...... |
Chromosomal Location | 14q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FANCM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | FANCM |
Name | Fanconi anemia, complementation group M |
Aliases | FAAP250; KIAA1596; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; prote ...... |
Chromosomal Location | 14q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FANCM in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FANCM |
Name | Fanconi anemia, complementation group M |
Aliases | FAAP250; KIAA1596; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; prote ...... |
Chromosomal Location | 14q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FANCM in various data sets.
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Points in the above scatter plot represent the mutation difference of FANCM in various data sets.
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Summary | |
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Symbol | FANCM |
Name | Fanconi anemia, complementation group M |
Aliases | FAAP250; KIAA1596; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; prote ...... |
Chromosomal Location | 14q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FANCM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FANCM |
Name | Fanconi anemia, complementation group M |
Aliases | FAAP250; KIAA1596; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; prote ...... |
Chromosomal Location | 14q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FANCM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FANCM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FANCM |
Name | Fanconi anemia, complementation group M |
Aliases | FAAP250; KIAA1596; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; prote ...... |
Chromosomal Location | 14q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FANCM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FANCM |
Name | Fanconi anemia, complementation group M |
Aliases | FAAP250; KIAA1596; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; prote ...... |
Chromosomal Location | 14q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FANCM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FANCM |
Name | Fanconi anemia, complementation group M |
Aliases | FAAP250; KIAA1596; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; prote ...... |
Chromosomal Location | 14q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FANCM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FANCM |
Name | Fanconi anemia, complementation group M |
Aliases | FAAP250; KIAA1596; ATP-dependent RNA helicase FANCM; fanconi anemia-associated polypeptide of 250 kDa; prote ...... |
Chromosomal Location | 14q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FANCM collected from DrugBank database. |
There is no record. |