Summary | |
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Symbol | FARSA |
Name | phenylalanyl-tRNA synthetase, alpha subunit |
Aliases | CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF01409 tRNA synthetases class II core domain (F) |
Function |
- |
Biological Process |
GO:0006399 tRNA metabolic process GO:0006418 tRNA aminoacylation for protein translation GO:0006432 phenylalanyl-tRNA aminoacylation GO:0006520 cellular amino acid metabolic process GO:0043038 amino acid activation GO:0043039 tRNA aminoacylation GO:0051259 protein oligomerization GO:0051262 protein tetramerization GO:0051290 protein heterotetramerization GO:0051291 protein heterooligomerization |
Molecular Function |
GO:0000049 tRNA binding GO:0004812 aminoacyl-tRNA ligase activity GO:0004826 phenylalanine-tRNA ligase activity GO:0016874 ligase activity GO:0016875 ligase activity, forming carbon-oxygen bonds GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds |
Cellular Component |
GO:0009328 phenylalanine-tRNA ligase complex |
KEGG |
hsa00970 Aminoacyl-tRNA biosynthesis |
Reactome |
R-HSA-379716: Cytosolic tRNA aminoacylation R-HSA-74160: Gene Expression R-HSA-379724: tRNA Aminoacylation |
Summary | |
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Symbol | FARSA |
Name | phenylalanyl-tRNA synthetase, alpha subunit |
Aliases | CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FARSA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FARSA |
Name | phenylalanyl-tRNA synthetase, alpha subunit |
Aliases | CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FARSA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FARSA |
Name | phenylalanyl-tRNA synthetase, alpha subunit |
Aliases | CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FARSA in various data sets.
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Points in the above scatter plot represent the mutation difference of FARSA in various data sets.
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Summary | |
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Symbol | FARSA |
Name | phenylalanyl-tRNA synthetase, alpha subunit |
Aliases | CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FARSA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FARSA |
Name | phenylalanyl-tRNA synthetase, alpha subunit |
Aliases | CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FARSA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FARSA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FARSA |
Name | phenylalanyl-tRNA synthetase, alpha subunit |
Aliases | CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FARSA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FARSA |
Name | phenylalanyl-tRNA synthetase, alpha subunit |
Aliases | CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FARSA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FARSA |
Name | phenylalanyl-tRNA synthetase, alpha subunit |
Aliases | CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FARSA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FARSA |
Name | phenylalanyl-tRNA synthetase, alpha subunit |
Aliases | CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FARSA collected from DrugBank database. |
Details on drugs targeting FARSA.
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