Browse FARSA

Summary
SymbolFARSA
Namephenylalanyl-tRNA synthetase, alpha subunit
Aliases CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ......
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm
Domain PF01409 tRNA synthetases class II core domain (F)
Function

-

> Gene Ontology
 
Biological Process GO:0006399 tRNA metabolic process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0006520 cellular amino acid metabolic process
GO:0043038 amino acid activation
GO:0043039 tRNA aminoacylation
GO:0051259 protein oligomerization
GO:0051262 protein tetramerization
GO:0051290 protein heterotetramerization
GO:0051291 protein heterooligomerization
Molecular Function GO:0000049 tRNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0016874 ligase activity
GO:0016875 ligase activity, forming carbon-oxygen bonds
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
Cellular Component GO:0009328 phenylalanine-tRNA ligase complex
> KEGG and Reactome Pathway
 
KEGG hsa00970 Aminoacyl-tRNA biosynthesis
Reactome R-HSA-379716: Cytosolic tRNA aminoacylation
R-HSA-74160: Gene Expression
R-HSA-379724: tRNA Aminoacylation
Summary
SymbolFARSA
Namephenylalanyl-tRNA synthetase, alpha subunit
Aliases CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ......
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FARSA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolFARSA
Namephenylalanyl-tRNA synthetase, alpha subunit
Aliases CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ......
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FARSA in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.55 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFARSA
Namephenylalanyl-tRNA synthetase, alpha subunit
Aliases CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ......
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FARSA in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0180.945
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0740.979
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0880.965
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2570.494
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1360.945
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4130.873
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0730.833
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1460.925
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3210.852
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1010.951
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1940.938
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0940.133
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FARSA in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFARSA
Namephenylalanyl-tRNA synthetase, alpha subunit
Aliases CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ......
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FARSA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFARSA
Namephenylalanyl-tRNA synthetase, alpha subunit
Aliases CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ......
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FARSA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FARSA.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFARSA
Namephenylalanyl-tRNA synthetase, alpha subunit
Aliases CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ......
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FARSA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFARSA
Namephenylalanyl-tRNA synthetase, alpha subunit
Aliases CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ......
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FARSA expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFARSA
Namephenylalanyl-tRNA synthetase, alpha subunit
Aliases CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ......
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FARSA and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFARSA
Namephenylalanyl-tRNA synthetase, alpha subunit
Aliases CML33; phenylalanine tRNA ligase 1, alpha, cytoplasmic; FARSL; FARSLA; phenylalanine-tRNA synthetase-like; p ......
Chromosomal Location19p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FARSA collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting FARSA.
ID Name Drug Type Targets #Targets
DB00120L-PhenylalanineSmall MoleculeFARS2, FARSA, FARSB, PAH, SLC7A8, TAT, TH7