Summary | |
---|---|
Symbol | FAS |
Name | Fas cell surface death receptor |
Aliases | CD95; APO-1; TNF receptor superfamily member 6; FAS1; TNFRSF6; tumor necrosis factor receptor superfamily, m ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted.; SUBCELLULAR LOCATION: Isoform 3: Secreted.; SUBCELLULAR LOCATION: Isoform 4: Secreted.; SUBCELLULAR LOCATION: Isoform 5: Secreted.; SUBCELLULAR LOCATION: Isoform 6: Secreted. |
Domain |
PF00531 Death domain PF00020 TNFR/NGFR cysteine-rich region |
Function |
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). |
Biological Process |
GO:0001776 leukocyte homeostasis GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002260 lymphocyte homeostasis GO:0002377 immunoglobulin production GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0003014 renal system process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006924 activation-induced cell death of T cells GO:0006925 inflammatory cell apoptotic process GO:0007159 leukocyte cell-cell adhesion GO:0007623 circadian rhythm GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0009612 response to mechanical stimulus GO:0009636 response to toxic substance GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010226 response to lithium ion GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0019724 B cell mediated immunity GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030217 T cell differentiation GO:0031334 positive regulation of protein complex assembly GO:0031960 response to corticosteroid GO:0032459 regulation of protein oligomerization GO:0032461 positive regulation of protein oligomerization GO:0032462 regulation of protein homooligomerization GO:0032464 positive regulation of protein homooligomerization GO:0032496 response to lipopolysaccharide GO:0033077 T cell differentiation in thymus GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034612 response to tumor necrosis factor GO:0036295 cellular response to increased oxygen levels GO:0036296 response to increased oxygen levels GO:0038034 signal transduction in absence of ligand GO:0042110 T cell activation GO:0042113 B cell activation GO:0043029 T cell homeostasis GO:0043254 regulation of protein complex assembly GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043383 negative T cell selection GO:0043410 positive regulation of MAPK cascade GO:0044089 positive regulation of cellular component biogenesis GO:0045058 T cell selection GO:0045060 negative thymic T cell selection GO:0045061 thymic T cell selection GO:0045619 regulation of lymphocyte differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045862 positive regulation of proteolysis GO:0048511 rhythmic process GO:0048536 spleen development GO:0048545 response to steroid hormone GO:0048872 homeostasis of number of cells GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050869 negative regulation of B cell activation GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051384 response to glucocorticoid GO:0051402 neuron apoptotic process GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0055093 response to hyperoxia GO:0070227 lymphocyte apoptotic process GO:0070228 regulation of lymphocyte apoptotic process GO:0070230 positive regulation of lymphocyte apoptotic process GO:0070231 T cell apoptotic process GO:0070265 necrotic cell death GO:0070266 necroptotic process GO:0070482 response to oxygen levels GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070997 neuron death GO:0071214 cellular response to abiotic stimulus GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071260 cellular response to mechanical stimulus GO:0071285 cellular response to lithium ion GO:0071356 cellular response to tumor necrosis factor GO:0071453 cellular response to oxygen levels GO:0071455 cellular response to hyperoxia GO:0071496 cellular response to external stimulus GO:0071593 lymphocyte aggregation GO:0071594 thymocyte aggregation GO:0071887 leukocyte apoptotic process GO:0097049 motor neuron apoptotic process GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097284 hepatocyte apoptotic process GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097300 programmed necrotic cell death GO:0097527 necroptotic signaling pathway GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902105 regulation of leukocyte differentiation GO:1903706 regulation of hemopoiesis GO:1904019 epithelial cell apoptotic process GO:2000106 regulation of leukocyte apoptotic process GO:2000108 positive regulation of leukocyte apoptotic process GO:2000116 regulation of cysteine-type endopeptidase activity GO:2001056 positive regulation of cysteine-type endopeptidase activity GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
Molecular Function |
GO:0005031 tumor necrosis factor-activated receptor activity GO:0005035 death receptor activity |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0031264 death-inducing signaling complex GO:0031265 CD95 death-inducing signaling complex GO:0045121 membrane raft GO:0098552 side of membrane GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04010 MAPK signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04115 p53 signaling pathway hsa04210 Apoptosis hsa04650 Natural killer cell mediated cytotoxicity hsa04668 TNF signaling pathway |
Reactome |
R-HSA-109581: Apoptosis R-HSA-5218900: CASP8 activity is inhibited R-HSA-5357769: Caspase activation via extrinsic apoptotic signalling pathway R-HSA-73887: Death Receptor Signalling R-HSA-69416: Dimerization of procaspase-8 R-HSA-75157: FasL/ CD95L signaling R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-140534: Ligand-dependent caspase activation R-HSA-5357801: Programmed Cell Death R-HSA-5213460: RIPK1-mediated regulated necrosis R-HSA-5218859: Regulated Necrosis R-HSA-3371378: Regulation by c-FLIP R-HSA-5675482: Regulation of necroptotic cell death R-HSA-162582: Signal Transduction R-HSA-5633008: TP53 Regulates Transcription of Cell Death Genes R-HSA-6803211: TP53 Regulates Transcription of Death Receptors and Ligands R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
---|---|
Symbol | FAS |
Name | Fas cell surface death receptor |
Aliases | CD95; APO-1; TNF receptor superfamily member 6; FAS1; TNFRSF6; tumor necrosis factor receptor superfamily, m ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FAS and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FAS and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | FAS |
Name | Fas cell surface death receptor |
Aliases | CD95; APO-1; TNF receptor superfamily member 6; FAS1; TNFRSF6; tumor necrosis factor receptor superfamily, m ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of FAS in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | FAS |
Name | Fas cell surface death receptor |
Aliases | CD95; APO-1; TNF receptor superfamily member 6; FAS1; TNFRSF6; tumor necrosis factor receptor superfamily, m ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FAS in various data sets.
|
Points in the above scatter plot represent the mutation difference of FAS in various data sets.
|
Summary | |
---|---|
Symbol | FAS |
Name | Fas cell surface death receptor |
Aliases | CD95; APO-1; TNF receptor superfamily member 6; FAS1; TNFRSF6; tumor necrosis factor receptor superfamily, m ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FAS. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FAS |
Name | Fas cell surface death receptor |
Aliases | CD95; APO-1; TNF receptor superfamily member 6; FAS1; TNFRSF6; tumor necrosis factor receptor superfamily, m ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FAS. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FAS. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FAS |
Name | Fas cell surface death receptor |
Aliases | CD95; APO-1; TNF receptor superfamily member 6; FAS1; TNFRSF6; tumor necrosis factor receptor superfamily, m ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FAS. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FAS |
Name | Fas cell surface death receptor |
Aliases | CD95; APO-1; TNF receptor superfamily member 6; FAS1; TNFRSF6; tumor necrosis factor receptor superfamily, m ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FAS expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FAS |
Name | Fas cell surface death receptor |
Aliases | CD95; APO-1; TNF receptor superfamily member 6; FAS1; TNFRSF6; tumor necrosis factor receptor superfamily, m ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FAS and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FAS |
Name | Fas cell surface death receptor |
Aliases | CD95; APO-1; TNF receptor superfamily member 6; FAS1; TNFRSF6; tumor necrosis factor receptor superfamily, m ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FAS collected from DrugBank database. |
There is no record. |