TISIDB

Summary
Symbol	FBXO32
Name	F-box protein 32
Aliases	MAFbx; ATROGIN1; Fbx32; F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
Chromosomal Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm Nucleus Note=Shuttles between cytoplasm and the nucleus.
Domain	-
Function	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.

> Gene Ontology [ TOP ]
Biological Process	GO:0014854 response to inactivity GO:0014870 response to muscle inactivity GO:0014874 response to stimulus involved in regulation of muscle adaptation GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation GO:0014894 response to denervation involved in regulation of muscle adaptation GO:0031960 response to corticosteroid GO:0043502 regulation of muscle adaptation GO:0044057 regulation of system process GO:0048545 response to steroid hormone GO:0051384 response to glucocorticoid GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071548 response to dexamethasone GO:0071549 cellular response to dexamethasone stimulus GO:0090257 regulation of muscle system process GO:1901654 response to ketone GO:1901655 cellular response to ketone
Molecular Function	GO:0004842 ubiquitin-protein transferase activity GO:0019787 ubiquitin-like protein transferase activity
Cellular Component	GO:0000151 ubiquitin ligase complex GO:0019005 SCF ubiquitin ligase complex GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0031461 cullin-RING ubiquitin ligase complex GO:0031674 I band GO:0043292 contractile fiber GO:0044449 contractile fiber part

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04068 FoxO signaling pathway
Reactome	R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System

Summary
Symbol	FBXO32
Name	F-box protein 32
Aliases	MAFbx; ATROGIN1; Fbx32; F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
Chromosomal Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between FBXO32 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	FBXO32
Name	F-box protein 32
Aliases	MAFbx; ATROGIN1; Fbx32; F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
Chromosomal Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of FBXO32 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	FBXO32
Name	F-box protein 32
Aliases	MAFbx; ATROGIN1; Fbx32; F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
Chromosomal Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of FBXO32 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.182	0.662
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.766	0.668
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.24	0.864
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.176	0.0437
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.751	0.712
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-1.704	0.536
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.009	0.985
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.109	0.953
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.211	0.915
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.142	0.902
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.339	0.836
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.248	0.141

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of FBXO32 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	FBXO32
Name	F-box protein 32
Aliases	MAFbx; ATROGIN1; Fbx32; F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
Chromosomal Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FBXO32. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	FBXO32
Name	F-box protein 32
Aliases	MAFbx; ATROGIN1; Fbx32; F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
Chromosomal Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FBXO32. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FBXO32. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	FBXO32
Name	F-box protein 32
Aliases	MAFbx; ATROGIN1; Fbx32; F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
Chromosomal Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FBXO32. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	FBXO32
Name	F-box protein 32
Aliases	MAFbx; ATROGIN1; Fbx32; F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
Chromosomal Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of FBXO32 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	FBXO32
Name	F-box protein 32
Aliases	MAFbx; ATROGIN1; Fbx32; F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
Chromosomal Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between FBXO32 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	FBXO32
Name	F-box protein 32
Aliases	MAFbx; ATROGIN1; Fbx32; F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
Chromosomal Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting FBXO32 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse FBXO32