Summary | |
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Symbol | FCER2 |
Name | Fc fragment of IgE, low affinity II, receptor for (CD23) |
Aliases | CLEC4J; CD23; CD23A; FCE2; Fc fragment of IgE, low affinity II, receptor for (CD23A); BLAST-2; IGEBF; C-type ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23. |
Domain |
PF00059 Lectin C-type domain |
Function |
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). |
Biological Process |
GO:0001906 cell killing GO:0002250 adaptive immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002455 humoral immune response mediated by circulating immunoglobulin GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002712 regulation of B cell mediated immunity GO:0002714 positive regulation of B cell mediated immunity GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002889 regulation of immunoglobulin mediated immune response GO:0002891 positive regulation of immunoglobulin mediated immune response GO:0002920 regulation of humoral immune response GO:0002922 positive regulation of humoral immune response GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0006959 humoral immune response GO:0007219 Notch signaling pathway GO:0016064 immunoglobulin mediated immune response GO:0019724 B cell mediated immunity GO:0031341 regulation of cell killing GO:0031343 positive regulation of cell killing GO:0031640 killing of cells of other organism GO:0032768 regulation of monooxygenase activity GO:0032770 positive regulation of monooxygenase activity GO:0035821 modification of morphology or physiology of other organism GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0044364 disruption of cells of other organism GO:0050999 regulation of nitric-oxide synthase activity GO:0051000 positive regulation of nitric-oxide synthase activity GO:0051341 regulation of oxidoreductase activity GO:0051353 positive regulation of oxidoreductase activity GO:0051709 regulation of killing of cells of other organism GO:0051712 positive regulation of killing of cells of other organism GO:0051767 nitric-oxide synthase biosynthetic process GO:0051769 regulation of nitric-oxide synthase biosynthetic process GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process |
Molecular Function |
GO:0005178 integrin binding GO:0019863 IgE binding GO:0019865 immunoglobulin binding GO:0030246 carbohydrate binding GO:0050839 cell adhesion molecule binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6783783: Interleukin-10 signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-2197563: NOTCH2 intracellular domain regulates transcription R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-157118: Signaling by NOTCH R-HSA-1980145: Signaling by NOTCH2 |
Summary | |
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Symbol | FCER2 |
Name | Fc fragment of IgE, low affinity II, receptor for (CD23) |
Aliases | CLEC4J; CD23; CD23A; FCE2; Fc fragment of IgE, low affinity II, receptor for (CD23A); BLAST-2; IGEBF; C-type ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FCER2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FCER2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FCER2 |
Name | Fc fragment of IgE, low affinity II, receptor for (CD23) |
Aliases | CLEC4J; CD23; CD23A; FCE2; Fc fragment of IgE, low affinity II, receptor for (CD23A); BLAST-2; IGEBF; C-type ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FCER2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FCER2 |
Name | Fc fragment of IgE, low affinity II, receptor for (CD23) |
Aliases | CLEC4J; CD23; CD23A; FCE2; Fc fragment of IgE, low affinity II, receptor for (CD23A); BLAST-2; IGEBF; C-type ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FCER2 in various data sets.
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Points in the above scatter plot represent the mutation difference of FCER2 in various data sets.
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Summary | |
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Symbol | FCER2 |
Name | Fc fragment of IgE, low affinity II, receptor for (CD23) |
Aliases | CLEC4J; CD23; CD23A; FCE2; Fc fragment of IgE, low affinity II, receptor for (CD23A); BLAST-2; IGEBF; C-type ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FCER2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FCER2 |
Name | Fc fragment of IgE, low affinity II, receptor for (CD23) |
Aliases | CLEC4J; CD23; CD23A; FCE2; Fc fragment of IgE, low affinity II, receptor for (CD23A); BLAST-2; IGEBF; C-type ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FCER2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FCER2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FCER2 |
Name | Fc fragment of IgE, low affinity II, receptor for (CD23) |
Aliases | CLEC4J; CD23; CD23A; FCE2; Fc fragment of IgE, low affinity II, receptor for (CD23A); BLAST-2; IGEBF; C-type ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FCER2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FCER2 |
Name | Fc fragment of IgE, low affinity II, receptor for (CD23) |
Aliases | CLEC4J; CD23; CD23A; FCE2; Fc fragment of IgE, low affinity II, receptor for (CD23A); BLAST-2; IGEBF; C-type ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FCER2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FCER2 |
Name | Fc fragment of IgE, low affinity II, receptor for (CD23) |
Aliases | CLEC4J; CD23; CD23A; FCE2; Fc fragment of IgE, low affinity II, receptor for (CD23A); BLAST-2; IGEBF; C-type ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FCER2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FCER2 |
Name | Fc fragment of IgE, low affinity II, receptor for (CD23) |
Aliases | CLEC4J; CD23; CD23A; FCE2; Fc fragment of IgE, low affinity II, receptor for (CD23A); BLAST-2; IGEBF; C-type ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FCER2 collected from DrugBank database. |
Details on drugs targeting FCER2.
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