Summary | |
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Symbol | FCGR1A |
Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Aliases | CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCRI; Fc gamma receptor; Fc-gamma RI ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Note=Stabilized at the cell membrane through interaction with FCER1G. |
Domain |
PF00047 Immunoglobulin domain PF13895 Immunoglobulin domain |
Function |
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. |
Biological Process |
GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0002478 antigen processing and presentation of exogenous peptide antigen GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006898 receptor-mediated endocytosis GO:0006909 phagocytosis GO:0006911 phagocytosis, engulfment GO:0010324 membrane invagination GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0034341 response to interferon-gamma GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0048002 antigen processing and presentation of peptide antigen GO:0060333 interferon-gamma-mediated signaling pathway GO:0071346 cellular response to interferon-gamma GO:0099024 plasma membrane invagination |
Molecular Function |
GO:0005057 receptor signaling protein activity GO:0019864 IgG binding GO:0019865 immunoglobulin binding |
Cellular Component |
GO:0005769 early endosome GO:0010008 endosome membrane GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030669 clathrin-coated endocytic vesicle membrane GO:0031901 early endosome membrane GO:0044440 endosomal part GO:0045334 clathrin-coated endocytic vesicle |
KEGG |
hsa04145 Phagosome hsa04380 Osteoclast differentiation hsa04640 Hematopoietic cell lineage hsa04666 Fc gamma R-mediated phagocytosis |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-1236975: Antigen processing-Cross presentation R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-1236978: Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2029481: FCGR activation R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-168249: Innate Immune System R-HSA-913531: Interferon Signaling R-HSA-877300: Interferon gamma signaling R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485: Role of phospholipids in phagocytosis |
Summary | |
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Symbol | FCGR1A |
Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Aliases | CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCRI; Fc gamma receptor; Fc-gamma RI ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FCGR1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FCGR1A and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FCGR1A |
Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Aliases | CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCRI; Fc gamma receptor; Fc-gamma RI ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FCGR1A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FCGR1A |
Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Aliases | CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCRI; Fc gamma receptor; Fc-gamma RI ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FCGR1A in various data sets.
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Points in the above scatter plot represent the mutation difference of FCGR1A in various data sets.
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Summary | |
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Symbol | FCGR1A |
Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Aliases | CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCRI; Fc gamma receptor; Fc-gamma RI ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FCGR1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FCGR1A |
Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Aliases | CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCRI; Fc gamma receptor; Fc-gamma RI ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FCGR1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FCGR1A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FCGR1A |
Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Aliases | CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCRI; Fc gamma receptor; Fc-gamma RI ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FCGR1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FCGR1A |
Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Aliases | CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCRI; Fc gamma receptor; Fc-gamma RI ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FCGR1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FCGR1A |
Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Aliases | CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCRI; Fc gamma receptor; Fc-gamma RI ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FCGR1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FCGR1A |
Name | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
Aliases | CD64; CD64A; Fc fragment of IgG, high affinity Ia, receptor for (CD64); FCRI; Fc gamma receptor; Fc-gamma RI ...... |
Chromosomal Location | 1q21.2-q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FCGR1A collected from DrugBank database. |
Details on drugs targeting FCGR1A.
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