Summary | |
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Symbol | FCGR2A |
Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
Aliases | CD32A; Immunoglobulin G Fc receptor II; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor for (CD32); ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain |
PF13895 Immunoglobulin domain |
Function |
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. |
Biological Process |
GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006909 phagocytosis GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis |
Molecular Function |
GO:0019864 IgG binding GO:0019865 immunoglobulin binding |
Cellular Component | - |
KEGG |
hsa04145 Phagosome hsa04380 Osteoclast differentiation hsa04611 Platelet activation hsa04666 Fc gamma R-mediated phagocytosis |
Reactome |
R-HSA-2029481: FCGR activation R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485: Role of phospholipids in phagocytosis |
Summary | |
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Symbol | FCGR2A |
Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
Aliases | CD32A; Immunoglobulin G Fc receptor II; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor for (CD32); ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FCGR2A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FCGR2A and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FCGR2A |
Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
Aliases | CD32A; Immunoglobulin G Fc receptor II; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor for (CD32); ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FCGR2A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FCGR2A |
Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
Aliases | CD32A; Immunoglobulin G Fc receptor II; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor for (CD32); ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FCGR2A in various data sets.
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Points in the above scatter plot represent the mutation difference of FCGR2A in various data sets.
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Summary | |
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Symbol | FCGR2A |
Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
Aliases | CD32A; Immunoglobulin G Fc receptor II; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor for (CD32); ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FCGR2A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FCGR2A |
Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
Aliases | CD32A; Immunoglobulin G Fc receptor II; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor for (CD32); ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FCGR2A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FCGR2A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FCGR2A |
Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
Aliases | CD32A; Immunoglobulin G Fc receptor II; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor for (CD32); ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FCGR2A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FCGR2A |
Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
Aliases | CD32A; Immunoglobulin G Fc receptor II; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor for (CD32); ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FCGR2A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FCGR2A |
Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
Aliases | CD32A; Immunoglobulin G Fc receptor II; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor for (CD32); ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FCGR2A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FCGR2A |
Name | Fc fragment of IgG, low affinity IIa, receptor (CD32) |
Aliases | CD32A; Immunoglobulin G Fc receptor II; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor for (CD32); ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FCGR2A collected from DrugBank database. |
Details on drugs targeting FCGR2A.
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