Browse FCGR2B

Summary
SymbolFCGR2B
NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Aliases CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ......
Chromosomal Location1q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Domain PF13895 Immunoglobulin domain
Function

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

> Gene Ontology
 
Biological Process -
Molecular Function GO:0019864 IgG binding
GO:0019865 immunoglobulin binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04145 Phagosome
hsa04380 Osteoclast differentiation
hsa04662 B cell receptor signaling pathway
hsa04666 Fc gamma R-mediated phagocytosis
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-168256: Immune System
R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Summary
SymbolFCGR2B
NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Aliases CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ......
Chromosomal Location1q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FCGR2B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between FCGR2B and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28410988Melanoma; Non-small Cell Lung Carcinoma; Renal Cell CarcinomaInhibit immunityWhile existing anti-CD25 antibodies were observed to deplete Treg cells in the periphery, upregulation of the inhibitory Fc gamma receptor (FcγR) IIb at the tumor site prevented intra-tumoral Treg cell depletion, which may underlie the lack of anti-tumor activity previously observed in pre-clinical models. Use of an anti-CD25 antibody with enhanced binding to activating FcγRs led to effective depletion of tumor-infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors.
Summary
SymbolFCGR2B
NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Aliases CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ......
Chromosomal Location1q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FCGR2B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFCGR2B
NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Aliases CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ......
Chromosomal Location1q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FCGR2B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.240.593
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1210.941
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3360.761
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2790.573
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1510.922
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.450.834
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0260.961
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2310.874
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2650.875
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2810.867
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.6930.458
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1080.61
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FCGR2B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.26.2160.53
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 594011.128.90.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFCGR2B
NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Aliases CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ......
Chromosomal Location1q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FCGR2B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFCGR2B
NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Aliases CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ......
Chromosomal Location1q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FCGR2B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FCGR2B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFCGR2B
NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Aliases CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ......
Chromosomal Location1q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FCGR2B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFCGR2B
NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Aliases CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ......
Chromosomal Location1q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FCGR2B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFCGR2B
NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Aliases CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ......
Chromosomal Location1q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FCGR2B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFCGR2B
NameFc fragment of IgG, low affinity IIb, receptor (CD32)
Aliases CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ......
Chromosomal Location1q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FCGR2B collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting FCGR2B.
ID Name Drug Type Targets #Targets
DB00002CetuximabBiotechC1QA, C1QB, C1QC, C1R, C1S, EGFR, FCGR1A, FCGR2A, FCGR2B, FCGR2C, ......12
DB00005EtanerceptBiotechC1QA, C1QB, C1QC, C1R, C1S, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A ......14
DB00028Immune Globulin HumanBiotechC3, C4A, C4B, C5, FCGR1A, FCGR1B, FCGR2A, FCGR2B, FCGR2C, FCGR3A, ......11
DB00051AdalimumabBiotechC1QA, C1QB, C1QC, C1R, C1S, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A ......12
DB00054AbciximabBiotechC1QA, C1QB, C1QC, C1R, C1S, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A ......14
DB00056Gemtuzumab ozogamicinBiotechC1QA, C1QB, C1QC, C1R, C1S, CD33, FCGR1A, FCGR2A, FCGR2B, FCGR2C, ......12
DB00072TrastuzumabBiotechC1QA, C1QB, C1QC, C1R, C1S, EGFR, ERBB2, FCGR1A, FCGR2A, FCGR2B, F ......13
DB00073RituximabBiotechC1QA, C1QB, C1QC, C1R, C1S, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A ......12
DB00074BasiliximabBiotechC1QA, C1QB, C1QC, C1R, C1S, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A ......13
DB00075MuromonabBiotechC1QA, C1QB, C1QC, C1R, C1S, CD247, CD3D, CD3E, CD3G, FCGR1A, FCGR2 ......15
DB00078Ibritumomab tiuxetanBiotechC1QA, C1QB, C1QC, C1R, C1S, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A ......12
DB00081TositumomabBiotechC1QA, C1QB, C1QC, C1R, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCG ......11
DB00087AlemtuzumabBiotechC1QA, C1QB, C1QC, C1R, CD52, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3 ......11
DB00092AlefaceptBiotechC1QA, C1QB, C1QC, C1R, CD2, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A ......11
DB00095EfalizumabBiotechC1QA, C1QB, C1QC, C1R, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCG ......11
DB00098Antithymocyte immunoglobulin (rabbit)BiotechCD1A, CD4, CD86, FCGR2B, ITGAL, ITGAV, ITGB1, ITGB3, MR19
DB00108NatalizumabBiotechC1QA, C1QB, C1QC, C1R, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCG ......12
DB00110PalivizumabBiotechC1QA, C1QB, C1QC, C1R, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCG ......10
DB00111DaclizumabBiotechC1QA, C1QB, C1QC, C1R, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCG ......12
DB00112BevacizumabBiotechC1QA, C1QB, C1QC, C1R, FCGR1A, FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCG ......11
DB11767SarilumabBiotechFCGR1A, FCGR2A, FCGR2B, FCGR3A, FCGR3B, IL6R6