Summary | |
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Symbol | FCGR2B |
Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
Aliases | CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Domain |
PF13895 Immunoglobulin domain |
Function |
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
Biological Process | - |
Molecular Function |
GO:0019864 IgG binding GO:0019865 immunoglobulin binding |
Cellular Component | - |
KEGG |
hsa04145 Phagosome hsa04380 Osteoclast differentiation hsa04662 B cell receptor signaling pathway hsa04666 Fc gamma R-mediated phagocytosis |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Summary | |
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Symbol | FCGR2B |
Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
Aliases | CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FCGR2B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FCGR2B and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FCGR2B |
Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
Aliases | CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FCGR2B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FCGR2B |
Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
Aliases | CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FCGR2B in various data sets.
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Points in the above scatter plot represent the mutation difference of FCGR2B in various data sets.
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Summary | |
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Symbol | FCGR2B |
Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
Aliases | CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FCGR2B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FCGR2B |
Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
Aliases | CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FCGR2B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FCGR2B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FCGR2B |
Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
Aliases | CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FCGR2B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FCGR2B |
Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
Aliases | CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FCGR2B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FCGR2B |
Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
Aliases | CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FCGR2B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FCGR2B |
Name | Fc fragment of IgG, low affinity IIb, receptor (CD32) |
Aliases | CD32B; Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity II, recep ...... |
Chromosomal Location | 1q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FCGR2B collected from DrugBank database. |
Details on drugs targeting FCGR2B.
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