Summary | |
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Symbol | FCGRT |
Name | Fc fragment of IgG, receptor, transporter, alpha |
Aliases | FCRN; alpha-chain; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; immunoglobulin recept ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein |
Domain |
PF07654 Immunoglobulin C1-set domain PF00129 Class I Histocompatibility antigen |
Function |
Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511). |
Biological Process |
GO:0002414 immunoglobulin transcytosis in epithelial cells GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0019882 antigen processing and presentation GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0045056 transcytosis |
Molecular Function |
GO:0003823 antigen binding GO:0019763 immunoglobulin receptor activity GO:0019770 IgG receptor activity GO:0019864 IgG binding GO:0019865 immunoglobulin binding GO:0030881 beta-2-microglobulin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | FCGRT |
Name | Fc fragment of IgG, receptor, transporter, alpha |
Aliases | FCRN; alpha-chain; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; immunoglobulin recept ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FCGRT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FCGRT and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FCGRT |
Name | Fc fragment of IgG, receptor, transporter, alpha |
Aliases | FCRN; alpha-chain; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; immunoglobulin recept ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FCGRT in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FCGRT |
Name | Fc fragment of IgG, receptor, transporter, alpha |
Aliases | FCRN; alpha-chain; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; immunoglobulin recept ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FCGRT in various data sets.
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Points in the above scatter plot represent the mutation difference of FCGRT in various data sets.
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Summary | |
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Symbol | FCGRT |
Name | Fc fragment of IgG, receptor, transporter, alpha |
Aliases | FCRN; alpha-chain; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; immunoglobulin recept ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FCGRT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FCGRT |
Name | Fc fragment of IgG, receptor, transporter, alpha |
Aliases | FCRN; alpha-chain; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; immunoglobulin recept ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FCGRT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FCGRT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FCGRT |
Name | Fc fragment of IgG, receptor, transporter, alpha |
Aliases | FCRN; alpha-chain; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; immunoglobulin recept ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FCGRT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FCGRT |
Name | Fc fragment of IgG, receptor, transporter, alpha |
Aliases | FCRN; alpha-chain; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; immunoglobulin recept ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FCGRT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FCGRT |
Name | Fc fragment of IgG, receptor, transporter, alpha |
Aliases | FCRN; alpha-chain; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; immunoglobulin recept ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FCGRT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FCGRT |
Name | Fc fragment of IgG, receptor, transporter, alpha |
Aliases | FCRN; alpha-chain; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; immunoglobulin recept ...... |
Chromosomal Location | 19q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FCGRT collected from DrugBank database. |
There is no record. |