Summary | |
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Symbol | FCHO1 |
Name | FCH domain only 1 |
Aliases | KIAA0290; FCH domain only protein 1; F-BAR domain only protein 1 |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane, clathrin-coated pit Peripheral membrane protein Cytoplasmic side Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes. |
Domain |
PF00611 Fes/CIP4 PF10291 Muniscin C-terminal mu homology domain |
Function |
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. |
Biological Process |
GO:0006898 receptor-mediated endocytosis GO:0048268 clathrin coat assembly GO:0072583 clathrin-dependent endocytosis |
Molecular Function |
GO:0035612 AP-2 adaptor complex binding |
Cellular Component |
GO:0005905 clathrin-coated pit GO:0098589 membrane region |
KEGG | - |
Reactome |
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | FCHO1 |
Name | FCH domain only 1 |
Aliases | KIAA0290; FCH domain only protein 1; F-BAR domain only protein 1 |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FCHO1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FCHO1 |
Name | FCH domain only 1 |
Aliases | KIAA0290; FCH domain only protein 1; F-BAR domain only protein 1 |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FCHO1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FCHO1 |
Name | FCH domain only 1 |
Aliases | KIAA0290; FCH domain only protein 1; F-BAR domain only protein 1 |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FCHO1 in various data sets.
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Points in the above scatter plot represent the mutation difference of FCHO1 in various data sets.
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Summary | |
---|---|
Symbol | FCHO1 |
Name | FCH domain only 1 |
Aliases | KIAA0290; FCH domain only protein 1; F-BAR domain only protein 1 |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FCHO1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FCHO1 |
Name | FCH domain only 1 |
Aliases | KIAA0290; FCH domain only protein 1; F-BAR domain only protein 1 |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FCHO1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FCHO1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FCHO1 |
Name | FCH domain only 1 |
Aliases | KIAA0290; FCH domain only protein 1; F-BAR domain only protein 1 |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FCHO1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FCHO1 |
Name | FCH domain only 1 |
Aliases | KIAA0290; FCH domain only protein 1; F-BAR domain only protein 1 |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FCHO1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FCHO1 |
Name | FCH domain only 1 |
Aliases | KIAA0290; FCH domain only protein 1; F-BAR domain only protein 1 |
Chromosomal Location | 19p13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FCHO1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |