Browse FGF1

Summary
SymbolFGF1
Namefibroblast growth factor 1 (acidic)
Aliases AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location5q31.3-q33.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
Domain PF00167 Fibroblast growth factor
Function

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0001655 urogenital system development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001667 ameboidal-type cell migration
GO:0001759 organ induction
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0002040 sprouting angiogenesis
GO:0003002 regionalization
GO:0003156 regulation of animal organ formation
GO:0003158 endothelium development
GO:0003159 morphogenesis of an endothelium
GO:0003401 axis elongation
GO:0006066 alcohol metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006694 steroid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0007389 pattern specification process
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008654 phospholipid biosynthetic process
GO:0009266 response to temperature stimulus
GO:0009408 response to heat
GO:0010092 specification of animal organ identity
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010893 positive regulation of steroid biosynthetic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0016125 sterol metabolic process
GO:0016126 sterol biosynthetic process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0030258 lipid modification
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0031128 developmental induction
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0033674 positive regulation of kinase activity
GO:0034605 cellular response to heat
GO:0035239 tube morphogenesis
GO:0035766 cell chemotaxis to fibroblast growth factor
GO:0035767 endothelial cell chemotaxis
GO:0035768 endothelial cell chemotaxis to fibroblast growth factor
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0040017 positive regulation of locomotion
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043542 endothelial cell migration
GO:0044283 small molecule biosynthetic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045017 glycerolipid biosynthetic process
GO:0045540 regulation of cholesterol biosynthetic process
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045834 positive regulation of lipid metabolic process
GO:0045860 positive regulation of protein kinase activity
GO:0045940 positive regulation of steroid metabolic process
GO:0046165 alcohol biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046890 regulation of lipid biosynthetic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048514 blood vessel morphogenesis
GO:0048645 animal organ formation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050810 regulation of steroid biosynthetic process
GO:0050920 regulation of chemotaxis
GO:0051272 positive regulation of cellular component movement
GO:0051302 regulation of cell division
GO:0051781 positive regulation of cell division
GO:0060326 cell chemotaxis
GO:0060541 respiratory system development
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060602 branch elongation of an epithelium
GO:0060675 ureteric bud morphogenesis
GO:0060677 ureteric bud elongation
GO:0060681 branch elongation involved in ureteric bud branching
GO:0060993 kidney morphogenesis
GO:0061138 morphogenesis of a branching epithelium
GO:0061154 endothelial tube morphogenesis
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071774 response to fibroblast growth factor
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072073 kidney epithelium development
GO:0072078 nephron tubule morphogenesis
GO:0072080 nephron tubule development
GO:0072088 nephron epithelium morphogenesis
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090181 regulation of cholesterol metabolic process
GO:0090205 positive regulation of cholesterol metabolic process
GO:0090287 regulation of cellular response to growth factor stimulus
GO:1901342 regulation of vasculature development
GO:1901509 regulation of endothelial tube morphogenesis
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1902652 secondary alcohol metabolic process
GO:1902653 secondary alcohol biosynthetic process
GO:1902930 regulation of alcohol biosynthetic process
GO:1902932 positive regulation of alcohol biosynthetic process
GO:1903670 regulation of sprouting angiogenesis
GO:1903672 positive regulation of sprouting angiogenesis
GO:1904018 positive regulation of vasculature development
GO:1904847 regulation of cell chemotaxis to fibroblast growth factor
GO:1905330 regulation of morphogenesis of an epithelium
GO:2000027 regulation of organ morphogenesis
GO:2000147 positive regulation of cell motility
GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:2001026 regulation of endothelial cell chemotaxis
Molecular Function GO:0004713 protein tyrosine kinase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005178 integrin binding
GO:0005539 glycosaminoglycan binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0030544 Hsp70 protein binding
GO:0031072 heat shock protein binding
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0044548 S100 protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0050839 cell adhesion molecule binding
GO:0052742 phosphatidylinositol kinase activity
GO:0052813 phosphatidylinositol bisphosphate kinase activity
GO:0070851 growth factor receptor binding
GO:1901681 sulfur compound binding
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005938 cell cortex
GO:0099568 cytoplasmic region
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04390 Hippo signaling pathway
hsa04810 Regulation of actin cytoskeleton
Reactome R-HSA-170984: ARMS-mediated activation
R-HSA-2033519: Activated point mutants of FGFR2
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-5654687: Downstream signaling of activated FGFR1
R-HSA-5654696: Downstream signaling of activated FGFR2
R-HSA-5654708: Downstream signaling of activated FGFR3
R-HSA-5654716: Downstream signaling of activated FGFR4
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-190242: FGFR1 ligand binding and activation
R-HSA-1839124: FGFR1 mutant receptor activation
R-HSA-190370: FGFR1b ligand binding and activation
R-HSA-190373: FGFR1c ligand binding and activation
R-HSA-190241: FGFR2 ligand binding and activation
R-HSA-1839126: FGFR2 mutant receptor activation
R-HSA-190377: FGFR2b ligand binding and activation
R-HSA-190375: FGFR2c ligand binding and activation
R-HSA-190239: FGFR3 ligand binding and activation
R-HSA-2033514: FGFR3 mutant receptor activation
R-HSA-190371: FGFR3b ligand binding and activation
R-HSA-190372: FGFR3c ligand binding and activation
R-HSA-190322: FGFR4 ligand binding and activation
R-HSA-5654693: FRS-mediated FGFR1 signaling
R-HSA-5654700: FRS-mediated FGFR2 signaling
R-HSA-5654706: FRS-mediated FGFR3 signaling
R-HSA-5654712: FRS-mediated FGFR4 signaling
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-180292: GAB1 signalosome
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-5654726: Negative regulation of FGFR1 signaling
R-HSA-5654727: Negative regulation of FGFR2 signaling
R-HSA-5654732: Negative regulation of FGFR3 signaling
R-HSA-5654733: Negative regulation of FGFR4 signaling
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-5654689: PI-3K cascade
R-HSA-5654695: PI-3K cascade
R-HSA-5654710: PI-3K cascade
R-HSA-5654720: PI-3K cascade
R-HSA-109704: PI3K Cascade
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-5654219: Phospholipase C-mediated cascade
R-HSA-5654221: Phospholipase C-mediated cascade; FGFR2
R-HSA-5654227: Phospholipase C-mediated cascade; FGFR3
R-HSA-5654228: Phospholipase C-mediated cascade; FGFR4
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-5654688: SHC-mediated cascade
R-HSA-5654699: SHC-mediated cascade
R-HSA-5654704: SHC-mediated cascade
R-HSA-5654719: SHC-mediated cascade
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-190236: Signaling by FGFR
R-HSA-1226099: Signaling by FGFR in disease
R-HSA-5654736: Signaling by FGFR1
R-HSA-5655302: Signaling by FGFR1 in disease
R-HSA-5654738: Signaling by FGFR2
R-HSA-8851708: Signaling by FGFR2 IIIa TM
R-HSA-5655253: Signaling by FGFR2 in disease
R-HSA-5654741: Signaling by FGFR3
R-HSA-5655332: Signaling by FGFR3 in disease
R-HSA-8853338: Signaling by FGFR3 point mutants in cancer
R-HSA-5654743: Signaling by FGFR4
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-1839122: Signaling by activated point mutants of FGFR1
R-HSA-1839130: Signaling by activated point mutants of FGFR3
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
Summary
SymbolFGF1
Namefibroblast growth factor 1 (acidic)
Aliases AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location5q31.3-q33.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FGF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between FGF1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29666124melanomaInhibit immunityFgf1 Nuclear transcriptional profiling of neutrophils, performed as they respond to the earliest precursors of melanoma in vivo, revealed an intricate landscape of regulatory factors that may promote progression to melanoma, including Serpinb1l4, Fgf1, Fgf6, Cathepsin H, Galectin 1 and Galectin 3.
Summary
SymbolFGF1
Namefibroblast growth factor 1 (acidic)
Aliases AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location5q31.3-q33.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FGF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFGF1
Namefibroblast growth factor 1 (acidic)
Aliases AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location5q31.3-q33.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FGF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0650.0763
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.1950.354
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.9490.261
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1920.666
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1930.839
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1890.861
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3080.591
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8860.391
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2330.823
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8450.375
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.2370.0536
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.5190.0134
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FGF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFGF1
Namefibroblast growth factor 1 (acidic)
Aliases AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location5q31.3-q33.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FGF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFGF1
Namefibroblast growth factor 1 (acidic)
Aliases AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location5q31.3-q33.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FGF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FGF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFGF1
Namefibroblast growth factor 1 (acidic)
Aliases AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location5q31.3-q33.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FGF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFGF1
Namefibroblast growth factor 1 (acidic)
Aliases AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location5q31.3-q33.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FGF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFGF1
Namefibroblast growth factor 1 (acidic)
Aliases AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location5q31.3-q33.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FGF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFGF1
Namefibroblast growth factor 1 (acidic)
Aliases AFGF; ECGFA; ECGFB; HBGF1; ECGF-beta; FGF-alpha; GLIO703; heparin-binding growth factor 1; endothelial cell ......
Chromosomal Location5q31.3-q33.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FGF1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting FGF1.
ID Name Drug Type Targets #Targets
DB00686Pentosan PolysulfateSmall MoleculeFGF1, FGF2, FGF43
DB01025AmlexanoxSmall MoleculeFGF1, IL3, S100A12, S100A134
DB01109HeparinSmall MoleculeF10, FGF1, FGF19, FGF2, FGF4, FGFR1, FGFR2, FGFR4, HGF, PF4, SELP, ......12
DB01901SucrosofateSmall MoleculeFGF1, FGFR22
DB01942Formic AcidSmall MoleculeACYP2, CA2, CASK, CTBP1, CYTH2, FGF1, GGACT, GPHN, HMOX1, NOS1, PV ......12
DB02264O2-Sulfo-Glucuronic AcidSmall MoleculeFGF1, HGF, HS3ST3A13
DB03959N,O6-Disulfo-GlucosamineSmall MoleculeANXA5, FGF1, FGF2, HGF, HS3ST3A15
DB04409Naphthalene TrisulfonateSmall MoleculeFGF11
DB06589PazopanibSmall MoleculeFGF1, FGFR3, FLT1, FLT4, ITK, KDR, KIT, PDGFRA, PDGFRB, SH2B310
DB082385-AMINO-NAPHTALENE-2-MONOSULFONATESmall MoleculeFGF11