Summary | |
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Symbol | FGF12 |
Name | fibroblast growth factor 12 |
Aliases | FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ...... |
Chromosomal Location | 3q28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00167 Fibroblast growth factor |
Function |
Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. |
Biological Process |
GO:0001508 action potential GO:0002028 regulation of sodium ion transport GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0003254 regulation of membrane depolarization GO:0006814 sodium ion transport GO:0006936 muscle contraction GO:0006941 striated muscle contraction GO:0007507 heart development GO:0007626 locomotory behavior GO:0008015 blood circulation GO:0008344 adult locomotory behavior GO:0008543 fibroblast growth factor receptor signaling pathway GO:0010765 positive regulation of sodium ion transport GO:0010959 regulation of metal ion transport GO:0015672 monovalent inorganic cation transport GO:0019226 transmission of nerve impulse GO:0019228 neuronal action potential GO:0022898 regulation of transmembrane transporter activity GO:0030048 actin filament-based movement GO:0030534 adult behavior GO:0031644 regulation of neurological system process GO:0032409 regulation of transporter activity GO:0032410 negative regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032413 negative regulation of ion transmembrane transporter activity GO:0032844 regulation of homeostatic process GO:0034762 regulation of transmembrane transport GO:0034763 negative regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034766 negative regulation of ion transmembrane transport GO:0035637 multicellular organismal signaling GO:0035725 sodium ion transmembrane transport GO:0042391 regulation of membrane potential GO:0043270 positive regulation of ion transport GO:0043271 negative regulation of ion transport GO:0044057 regulation of system process GO:0044344 cellular response to fibroblast growth factor stimulus GO:0044708 single-organism behavior GO:0050905 neuromuscular process GO:0051051 negative regulation of transport GO:0051899 membrane depolarization GO:0051969 regulation of transmission of nerve impulse GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0070252 actin-mediated cell contraction GO:0071774 response to fibroblast growth factor GO:0086001 cardiac muscle cell action potential GO:0086002 cardiac muscle cell action potential involved in contraction GO:0086003 cardiac muscle cell contraction GO:0098900 regulation of action potential GO:0098908 regulation of neuronal action potential GO:1902305 regulation of sodium ion transmembrane transport GO:1904062 regulation of cation transmembrane transport GO:1904063 negative regulation of cation transmembrane transport GO:1905150 regulation of voltage-gated sodium channel activity GO:2000021 regulation of ion homeostasis GO:2000649 regulation of sodium ion transmembrane transporter activity GO:2001257 regulation of cation channel activity GO:2001258 negative regulation of cation channel activity |
Molecular Function |
GO:0008083 growth factor activity GO:0016247 channel regulator activity GO:0017080 sodium channel regulator activity GO:0044325 ion channel binding |
Cellular Component | - |
KEGG |
hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-5576891: Cardiac conduction R-HSA-397014: Muscle contraction R-HSA-5576892: Phase 0 - rapid depolarisation |
Summary | |
---|---|
Symbol | FGF12 |
Name | fibroblast growth factor 12 |
Aliases | FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ...... |
Chromosomal Location | 3q28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FGF12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FGF12 |
Name | fibroblast growth factor 12 |
Aliases | FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ...... |
Chromosomal Location | 3q28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FGF12 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | FGF12 |
Name | fibroblast growth factor 12 |
Aliases | FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ...... |
Chromosomal Location | 3q28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FGF12 in various data sets.
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Points in the above scatter plot represent the mutation difference of FGF12 in various data sets.
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Summary | |
---|---|
Symbol | FGF12 |
Name | fibroblast growth factor 12 |
Aliases | FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ...... |
Chromosomal Location | 3q28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FGF12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FGF12 |
Name | fibroblast growth factor 12 |
Aliases | FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ...... |
Chromosomal Location | 3q28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FGF12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FGF12. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FGF12 |
Name | fibroblast growth factor 12 |
Aliases | FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ...... |
Chromosomal Location | 3q28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FGF12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FGF12 |
Name | fibroblast growth factor 12 |
Aliases | FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ...... |
Chromosomal Location | 3q28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FGF12 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FGF12 |
Name | fibroblast growth factor 12 |
Aliases | FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ...... |
Chromosomal Location | 3q28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FGF12 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FGF12 |
Name | fibroblast growth factor 12 |
Aliases | FHF1; fibroblast growth factor 12B; fibroblast growth factor homologous factor 1; myocyte-activating factor; ...... |
Chromosomal Location | 3q28 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FGF12 collected from DrugBank database. |
There is no record. |