Summary | |
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Symbol | FGF19 |
Name | fibroblast growth factor 19 |
Aliases | FGF-19 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00167 Fibroblast growth factor |
Function |
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. |
Biological Process |
GO:0001667 ameboidal-type cell migration GO:0001755 neural crest cell migration GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006694 steroid biosynthetic process GO:0006699 bile acid biosynthetic process GO:0007254 JNK cascade GO:0007507 heart development GO:0008202 steroid metabolic process GO:0008206 bile acid metabolic process GO:0008543 fibroblast growth factor receptor signaling pathway GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0008654 phospholipid biosynthetic process GO:0010565 regulation of cellular ketone metabolic process GO:0010827 regulation of glucose transport GO:0010828 positive regulation of glucose transport GO:0010894 negative regulation of steroid biosynthetic process GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0016053 organic acid biosynthetic process GO:0019216 regulation of lipid metabolic process GO:0019218 regulation of steroid metabolic process GO:0030258 lipid modification GO:0031098 stress-activated protein kinase signaling cascade GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process GO:0042180 cellular ketone metabolic process GO:0043410 positive regulation of MAPK cascade GO:0044283 small molecule biosynthetic process GO:0044344 cellular response to fibroblast growth factor stimulus GO:0045017 glycerolipid biosynthetic process GO:0045833 negative regulation of lipid metabolic process GO:0045939 negative regulation of steroid metabolic process GO:0046323 glucose import GO:0046324 regulation of glucose import GO:0046326 positive regulation of glucose import GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046394 carboxylic acid biosynthetic process GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0046890 regulation of lipid biosynthetic process GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0050810 regulation of steroid biosynthetic process GO:0051055 negative regulation of lipid biosynthetic process GO:0051403 stress-activated MAPK cascade GO:0060485 mesenchyme development GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070857 regulation of bile acid biosynthetic process GO:0070858 negative regulation of bile acid biosynthetic process GO:0071774 response to fibroblast growth factor GO:0072330 monocarboxylic acid biosynthetic process GO:1904251 regulation of bile acid metabolic process GO:1904252 negative regulation of bile acid metabolic process |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005104 fibroblast growth factor receptor binding GO:0008083 growth factor activity GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0035004 phosphatidylinositol 3-kinase activity GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0052742 phosphatidylinositol kinase activity GO:0052813 phosphatidylinositol bisphosphate kinase activity GO:0070851 growth factor receptor binding |
Cellular Component | - |
KEGG |
hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-5654716: Downstream signaling of activated FGFR4 R-HSA-2871796: FCERI mediated MAPK activation R-HSA-190322: FGFR4 ligand binding and activation R-HSA-5654712: FRS-mediated FGFR4 signaling R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-180292: GAB1 signalosome R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-5654733: Negative regulation of FGFR4 signaling R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-5654720: PI-3K cascade R-HSA-109704: PI3K Cascade R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-5654228: Phospholipase C-mediated cascade; FGFR4 R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-5654719: SHC-mediated cascade R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-190236: Signaling by FGFR R-HSA-5654743: Signaling by FGFR4 R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation R-HSA-1307965: betaKlotho-mediated ligand binding |
Summary | |
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Symbol | FGF19 |
Name | fibroblast growth factor 19 |
Aliases | FGF-19 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FGF19 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | FGF19 |
Name | fibroblast growth factor 19 |
Aliases | FGF-19 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FGF19 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FGF19 |
Name | fibroblast growth factor 19 |
Aliases | FGF-19 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FGF19 in various data sets.
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There is no record. |
Summary | |
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Symbol | FGF19 |
Name | fibroblast growth factor 19 |
Aliases | FGF-19 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FGF19. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FGF19 |
Name | fibroblast growth factor 19 |
Aliases | FGF-19 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FGF19. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FGF19. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FGF19 |
Name | fibroblast growth factor 19 |
Aliases | FGF-19 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FGF19. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FGF19 |
Name | fibroblast growth factor 19 |
Aliases | FGF-19 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FGF19 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FGF19 |
Name | fibroblast growth factor 19 |
Aliases | FGF-19 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FGF19 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FGF19 |
Name | fibroblast growth factor 19 |
Aliases | FGF-19 |
Chromosomal Location | 11q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FGF19 collected from DrugBank database. |
Details on drugs targeting FGF19.
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