Browse FIP1L1

Summary
SymbolFIP1L1
Namefactor interacting with PAPOLA and CPSF1
Aliases DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF05182 Fip1 motif
Function

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.

> Gene Ontology
 
Biological Process GO:0000375 RNA splicing, via transesterification reactions
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000398 mRNA splicing, via spliceosome
GO:0006353 DNA-templated transcription, termination
GO:0006369 termination of RNA polymerase II transcription
GO:0006397 mRNA processing
GO:0006403 RNA localization
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006913 nucleocytoplasmic transport
GO:0008380 RNA splicing
GO:0015931 nucleobase-containing compound transport
GO:0031123 RNA 3'-end processing
GO:0031124 mRNA 3'-end processing
GO:0050657 nucleic acid transport
GO:0050658 RNA transport
GO:0051028 mRNA transport
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051236 establishment of RNA localization
GO:0071166 ribonucleoprotein complex localization
GO:0071426 ribonucleoprotein complex export from nucleus
GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus
Molecular Function -
Cellular Component GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:0005849 mRNA cleavage factor complex
> KEGG and Reactome Pathway
 
KEGG hsa03015 mRNA surveillance pathway
Reactome R-HSA-109688: Cleavage of Growing Transcript in the Termination Region
R-HSA-74160: Gene Expression
R-HSA-112296: Post-Elongation Processing of Intron-Containing pre-mRNA
R-HSA-112297: Post-Elongation Processing of Intronless pre-mRNA
R-HSA-76044: Post-Elongation Processing of the Transcript
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-HSA-75067: Processing of Capped Intronless Pre-mRNA
R-HSA-77595: Processing of Intronless Pre-mRNAs
R-HSA-73857: RNA Polymerase II Transcription
R-HSA-73856: RNA Polymerase II Transcription Termination
R-HSA-72202: Transport of Mature Transcript to Cytoplasm
R-HSA-159231: Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159234: Transport of Mature mRNAs Derived from Intronless Transcripts
R-HSA-72187: mRNA 3'-end processing
R-HSA-72172: mRNA Splicing
R-HSA-72163: mRNA Splicing - Major Pathway
Summary
SymbolFIP1L1
Namefactor interacting with PAPOLA and CPSF1
Aliases DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FIP1L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolFIP1L1
Namefactor interacting with PAPOLA and CPSF1
Aliases DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FIP1L1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.6 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFIP1L1
Namefactor interacting with PAPOLA and CPSF1
Aliases DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FIP1L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1630.433
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0150.994
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2950.838
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0890.707
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1680.936
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0120.996
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1420.634
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1010.939
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1810.9
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4390.755
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9640.645
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0750.144
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FIP1L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.212.59.70.602
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 594011.128.90.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFIP1L1
Namefactor interacting with PAPOLA and CPSF1
Aliases DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FIP1L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFIP1L1
Namefactor interacting with PAPOLA and CPSF1
Aliases DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FIP1L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FIP1L1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFIP1L1
Namefactor interacting with PAPOLA and CPSF1
Aliases DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FIP1L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFIP1L1
Namefactor interacting with PAPOLA and CPSF1
Aliases DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FIP1L1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFIP1L1
Namefactor interacting with PAPOLA and CPSF1
Aliases DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FIP1L1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFIP1L1
Namefactor interacting with PAPOLA and CPSF1
Aliases DKFZp586K0717; FIP1 like 1 (S. cerevisiae); FIP1L1 cleavage and polyadenylation specific factor subunit; hFi ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FIP1L1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.