Summary | |
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Symbol | FIS1 |
Name | fission, mitochondrial 1 |
Aliases | CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. |
Domain |
PF14853 Fis1 C-terminal tetratricopeptide repeat PF14852 Fis1 N-terminal tetratricopeptide repeat |
Function |
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. |
Biological Process |
GO:0000266 mitochondrial fission GO:0000422 mitophagy GO:0001836 release of cytochrome c from mitochondria GO:0006612 protein targeting to membrane GO:0006626 protein targeting to mitochondrion GO:0006839 mitochondrial transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006914 autophagy GO:0007031 peroxisome organization GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0008053 mitochondrial fusion GO:0008637 apoptotic mitochondrial changes GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0016559 peroxisome fission GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032469 endoplasmic reticulum calcium ion homeostasis GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration GO:0033157 regulation of intracellular protein transport GO:0035584 calcium-mediated signaling using intracellular calcium source GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043653 mitochondrial fragmentation involved in apoptotic process GO:0044801 single-organism membrane fusion GO:0045862 positive regulation of proteolysis GO:0048284 organelle fusion GO:0051222 positive regulation of protein transport GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051480 regulation of cytosolic calcium ion concentration GO:0051560 mitochondrial calcium ion homeostasis GO:0051561 positive regulation of mitochondrial calcium ion concentration GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0055074 calcium ion homeostasis GO:0061025 membrane fusion GO:0061726 mitochondrion disassembly GO:0070584 mitochondrion morphogenesis GO:0070585 protein localization to mitochondrion GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072655 establishment of protein localization to mitochondrion GO:0072657 protein localization to membrane GO:0090140 regulation of mitochondrial fission GO:0090141 positive regulation of mitochondrial fission GO:0090150 establishment of protein localization to membrane GO:0090313 regulation of protein targeting to membrane GO:0090314 positive regulation of protein targeting to membrane GO:0090316 positive regulation of intracellular protein transport GO:0097193 intrinsic apoptotic signaling pathway GO:1903008 organelle disassembly GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1904951 positive regulation of establishment of protein localization GO:2000116 regulation of cysteine-type endopeptidase activity GO:2001056 positive regulation of cysteine-type endopeptidase activity GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001244 positive regulation of intrinsic apoptotic signaling pathway |
Molecular Function | - |
Cellular Component |
GO:0005741 mitochondrial outer membrane GO:0005777 peroxisome GO:0005778 peroxisomal membrane GO:0005779 integral component of peroxisomal membrane GO:0019867 outer membrane GO:0031231 intrinsic component of peroxisomal membrane GO:0031300 intrinsic component of organelle membrane GO:0031301 integral component of organelle membrane GO:0031306 intrinsic component of mitochondrial outer membrane GO:0031307 integral component of mitochondrial outer membrane GO:0031903 microbody membrane GO:0031968 organelle outer membrane GO:0032592 integral component of mitochondrial membrane GO:0042579 microbody GO:0044438 microbody part GO:0044439 peroxisomal part GO:0044455 mitochondrial membrane part GO:0098573 intrinsic component of mitochondrial membrane |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | FIS1 |
Name | fission, mitochondrial 1 |
Aliases | CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FIS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FIS1 |
Name | fission, mitochondrial 1 |
Aliases | CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FIS1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | FIS1 |
Name | fission, mitochondrial 1 |
Aliases | CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FIS1 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | FIS1 |
Name | fission, mitochondrial 1 |
Aliases | CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FIS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FIS1 |
Name | fission, mitochondrial 1 |
Aliases | CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FIS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FIS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FIS1 |
Name | fission, mitochondrial 1 |
Aliases | CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FIS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FIS1 |
Name | fission, mitochondrial 1 |
Aliases | CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FIS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FIS1 |
Name | fission, mitochondrial 1 |
Aliases | CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FIS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FIS1 |
Name | fission, mitochondrial 1 |
Aliases | CGI-135; H_NH0132A01.6; CGI-135 protein; mitochondrial fission molecule; TTC11; tetratricopeptide repeat dom ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FIS1 collected from DrugBank database. |
There is no record. |