Browse FLCN

Summary
SymbolFLCN
Namefolliculin
Aliases MGC17998; MGC23445; FLCL; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.
Domain PF11704 Vesicle coat protein involved in Golgi to plasma membrane transport
PF16692 Folliculin C-terminal domain
Function

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

> Gene Ontology
 
Biological Process GO:0000002 mitochondrial genome maintenance
GO:0000910 cytokinesis
GO:0001558 regulation of cell growth
GO:0001655 urogenital system development
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001933 negative regulation of protein phosphorylation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0002328 pro-B cell differentiation
GO:0006091 generation of precursor metabolites and energy
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006754 ATP biosynthetic process
GO:0006914 autophagy
GO:0007043 cell-cell junction assembly
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0009116 nucleoside metabolic process
GO:0009118 regulation of nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009124 nucleoside monophosphate biosynthetic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009127 purine nucleoside monophosphate biosynthetic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009145 purine nucleoside triphosphate biosynthetic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009163 nucleoside biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009201 ribonucleoside triphosphate biosynthetic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009206 purine ribonucleoside triphosphate biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0010506 regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0010639 negative regulation of organelle organization
GO:0010821 regulation of mitochondrion organization
GO:0010823 negative regulation of mitochondrion organization
GO:0015980 energy derivation by oxidation of organic compounds
GO:0016049 cell growth
GO:0016570 histone modification
GO:0016573 histone acetylation
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030809 negative regulation of nucleotide biosynthetic process
GO:0031056 regulation of histone modification
GO:0031929 TOR signaling
GO:0032006 regulation of TOR signaling
GO:0032007 negative regulation of TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032042 mitochondrial DNA metabolic process
GO:0032465 regulation of cytokinesis
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034504 protein localization to nucleus
GO:0035023 regulation of Rho protein signal transduction
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035065 regulation of histone acetylation
GO:0040013 negative regulation of locomotion
GO:0042278 purine nucleoside metabolic process
GO:0042326 negative regulation of phosphorylation
GO:0042451 purine nucleoside biosynthetic process
GO:0042455 ribonucleoside biosynthetic process
GO:0043409 negative regulation of MAPK cascade
GO:0043457 regulation of cellular respiration
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043491 protein kinase B signaling
GO:0043543 protein acylation
GO:0043687 post-translational protein modification
GO:0045216 cell-cell junction organization
GO:0045333 cellular respiration
GO:0045785 positive regulation of cell adhesion
GO:0045926 negative regulation of growth
GO:0045978 negative regulation of nucleoside metabolic process
GO:0045980 negative regulation of nucleotide metabolic process
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046129 purine ribonucleoside biosynthetic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046578 regulation of Ras protein signal transduction
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048871 multicellular organismal homeostasis
GO:0051052 regulation of DNA metabolic process
GO:0051053 negative regulation of DNA metabolic process
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051058 negative regulation of small GTPase mediated signal transduction
GO:0051271 negative regulation of cellular component movement
GO:0051302 regulation of cell division
GO:0051896 regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
GO:0060537 muscle tissue development
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072001 renal system development
GO:0072111 cell proliferation involved in kidney development
GO:0072522 purine-containing compound biosynthetic process
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090183 regulation of kidney development
GO:0090185 negative regulation of kidney development
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0097009 energy homeostasis
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900180 regulation of protein localization to nucleus
GO:1900181 negative regulation of protein localization to nucleus
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900372 negative regulation of purine nucleotide biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900543 negative regulation of purine nucleotide metabolic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901532 regulation of hematopoietic progenitor cell differentiation
GO:1901657 glycosyl compound metabolic process
GO:1901659 glycosyl compound biosynthetic process
GO:1901722 regulation of cell proliferation involved in kidney development
GO:1901723 negative regulation of cell proliferation involved in kidney development
GO:1901856 negative regulation of cellular respiration
GO:1901858 regulation of mitochondrial DNA metabolic process
GO:1901859 negative regulation of mitochondrial DNA metabolic process
GO:1901861 regulation of muscle tissue development
GO:1901862 negative regulation of muscle tissue development
GO:1901873 regulation of post-translational protein modification
GO:1901874 negative regulation of post-translational protein modification
GO:1901983 regulation of protein acetylation
GO:1902275 regulation of chromatin organization
GO:1902532 negative regulation of intracellular signal transduction
GO:1903578 regulation of ATP metabolic process
GO:1903579 negative regulation of ATP metabolic process
GO:1903706 regulation of hemopoiesis
GO:1903828 negative regulation of cellular protein localization
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus
GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus
GO:2000146 negative regulation of cell motility
GO:2000505 regulation of energy homeostasis
GO:2000506 negative regulation of energy homeostasis
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000973 regulation of pro-B cell differentiation
GO:2001169 regulation of ATP biosynthetic process
GO:2001170 negative regulation of ATP biosynthetic process
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Cellular Component GO:0005929 cilium
GO:0030496 midbody
GO:0044291 cell-cell contact zone
GO:0072372 primary cilium
> KEGG and Reactome Pathway
 
KEGG hsa04150 mTOR signaling pathway
Reactome -
Summary
SymbolFLCN
Namefolliculin
Aliases MGC17998; MGC23445; FLCL; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FLCN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolFLCN
Namefolliculin
Aliases MGC17998; MGC23445; FLCL; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FLCN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.52 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFLCN
Namefolliculin
Aliases MGC17998; MGC23445; FLCL; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FLCN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0590.751
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2380.887
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0720.953
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0720.843
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2720.902
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1820.949
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1940.546
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2160.876
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.6690.668
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1170.927
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6120.725
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0530.481
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FLCN in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFLCN
Namefolliculin
Aliases MGC17998; MGC23445; FLCL; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FLCN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFLCN
Namefolliculin
Aliases MGC17998; MGC23445; FLCL; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FLCN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FLCN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFLCN
Namefolliculin
Aliases MGC17998; MGC23445; FLCL; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FLCN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFLCN
Namefolliculin
Aliases MGC17998; MGC23445; FLCL; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FLCN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFLCN
Namefolliculin
Aliases MGC17998; MGC23445; FLCL; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FLCN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFLCN
Namefolliculin
Aliases MGC17998; MGC23445; FLCL; BHD skin lesion fibrofolliculoma protein; birt-Hogg-Dube syndrome protein
Chromosomal Location17p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FLCN collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.