Summary | |
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Symbol | FLOT2 |
Name | flotillin 2 |
Aliases | ECS-1; ECS1; Flotillin 2 (epidermal surface antigen 1); membrane component, chromosome 17, surface marker 1 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Peripheral membrane protein Membrane, caveola Peripheral membrane protein Endosome Membrane Lipid-anchor Note=Membrane-associated protein of caveolae. |
Domain |
PF01145 SPFH domain / Band 7 family PF15975 Flotillin |
Function |
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. |
Biological Process |
GO:0001765 membrane raft assembly GO:0001767 establishment of lymphocyte polarity GO:0001768 establishment of T cell polarity GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0007009 plasma membrane organization GO:0007159 leukocyte cell-cell adhesion GO:0007163 establishment or maintenance of cell polarity GO:0008544 epidermis development GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030010 establishment of cell polarity GO:0031579 membrane raft organization GO:0031647 regulation of protein stability GO:0032878 regulation of establishment or maintenance of cell polarity GO:0042110 T cell activation GO:0042692 muscle cell differentiation GO:0042982 amyloid precursor protein metabolic process GO:0042987 amyloid precursor protein catabolic process GO:0044091 membrane biogenesis GO:0044860 protein localization to plasma membrane raft GO:0045445 myoblast differentiation GO:0045661 regulation of myoblast differentiation GO:0045785 positive regulation of cell adhesion GO:0050821 protein stabilization GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051147 regulation of muscle cell differentiation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:0071709 membrane assembly GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:1902991 regulation of amyloid precursor protein catabolic process GO:1902992 negative regulation of amyloid precursor protein catabolic process GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903044 protein localization to membrane raft GO:1903903 regulation of establishment of T cell polarity GO:1903905 positive regulation of establishment of T cell polarity GO:1990778 protein localization to cell periphery GO:2000114 regulation of establishment of cell polarity |
Molecular Function |
GO:0002020 protease binding GO:0035254 glutamate receptor binding GO:0035255 ionotropic glutamate receptor binding GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0001669 acrosomal vesicle GO:0001931 uropod GO:0002080 acrosomal membrane GO:0005901 caveola GO:0005913 cell-cell adherens junction GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0005938 cell cortex GO:0015629 actin cytoskeleton GO:0016323 basolateral plasma membrane GO:0016600 flotillin complex GO:0030027 lamellipodium GO:0030055 cell-substrate junction GO:0030139 endocytic vesicle GO:0030141 secretory granule GO:0030659 cytoplasmic vesicle membrane GO:0030667 secretory granule membrane GO:0030863 cortical cytoskeleton GO:0030864 cortical actin cytoskeleton GO:0031252 cell leading edge GO:0031254 cell trailing edge GO:0044291 cell-cell contact zone GO:0044448 cell cortex part GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0097223 sperm part GO:0098589 membrane region GO:0098857 membrane microdomain GO:0099503 secretory vesicle GO:0099568 cytoplasmic region |
KEGG |
hsa04910 Insulin signaling pathway |
Reactome |
R-HSA-112316: Neuronal System R-HSA-6794362: Protein-protein interactions at synapses R-HSA-8849932: SALM protein interactions at the synapses |
Summary | |
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Symbol | FLOT2 |
Name | flotillin 2 |
Aliases | ECS-1; ECS1; Flotillin 2 (epidermal surface antigen 1); membrane component, chromosome 17, surface marker 1 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FLOT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FLOT2 |
Name | flotillin 2 |
Aliases | ECS-1; ECS1; Flotillin 2 (epidermal surface antigen 1); membrane component, chromosome 17, surface marker 1 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FLOT2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | FLOT2 |
Name | flotillin 2 |
Aliases | ECS-1; ECS1; Flotillin 2 (epidermal surface antigen 1); membrane component, chromosome 17, surface marker 1 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FLOT2 in various data sets.
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Points in the above scatter plot represent the mutation difference of FLOT2 in various data sets.
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Summary | |
---|---|
Symbol | FLOT2 |
Name | flotillin 2 |
Aliases | ECS-1; ECS1; Flotillin 2 (epidermal surface antigen 1); membrane component, chromosome 17, surface marker 1 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FLOT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FLOT2 |
Name | flotillin 2 |
Aliases | ECS-1; ECS1; Flotillin 2 (epidermal surface antigen 1); membrane component, chromosome 17, surface marker 1 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FLOT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FLOT2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FLOT2 |
Name | flotillin 2 |
Aliases | ECS-1; ECS1; Flotillin 2 (epidermal surface antigen 1); membrane component, chromosome 17, surface marker 1 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FLOT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FLOT2 |
Name | flotillin 2 |
Aliases | ECS-1; ECS1; Flotillin 2 (epidermal surface antigen 1); membrane component, chromosome 17, surface marker 1 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FLOT2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FLOT2 |
Name | flotillin 2 |
Aliases | ECS-1; ECS1; Flotillin 2 (epidermal surface antigen 1); membrane component, chromosome 17, surface marker 1 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FLOT2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FLOT2 |
Name | flotillin 2 |
Aliases | ECS-1; ECS1; Flotillin 2 (epidermal surface antigen 1); membrane component, chromosome 17, surface marker 1 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FLOT2 collected from DrugBank database. |
There is no record. |