Summary | |
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Symbol | FLT3 |
Name | fms-related tyrosine kinase 3 |
Aliases | FLK2; CD135; FLK-2; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; g ...... |
Chromosomal Location | 13q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation. |
Domain |
PF00047 Immunoglobulin domain PF07714 Protein tyrosine kinase |
Function |
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. |
Biological Process |
GO:0001776 leukocyte homeostasis GO:0002244 hematopoietic progenitor cell differentiation GO:0002318 myeloid progenitor cell differentiation GO:0002320 lymphoid progenitor cell differentiation GO:0002328 pro-B cell differentiation GO:0002521 leukocyte differentiation GO:0006644 phospholipid metabolic process GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019216 regulation of lipid metabolic process GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031960 response to corticosteroid GO:0032943 mononuclear cell proliferation GO:0033674 positive regulation of kinase activity GO:0035726 common myeloid progenitor cell proliferation GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0038084 vascular endothelial growth factor signaling pathway GO:0042113 B cell activation GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043550 regulation of lipid kinase activity GO:0043551 regulation of phosphatidylinositol 3-kinase activity GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity GO:0045834 positive regulation of lipid metabolic process GO:0045860 positive regulation of protein kinase activity GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046651 lymphocyte proliferation GO:0046777 protein autophosphorylation GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048545 response to steroid hormone GO:0048872 homeostasis of number of cells GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0051384 response to glucocorticoid GO:0070661 leukocyte proliferation GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090218 positive regulation of lipid kinase activity GO:0097028 dendritic cell differentiation GO:0097696 STAT cascade GO:1903725 regulation of phospholipid metabolic process GO:1903727 positive regulation of phospholipid metabolic process GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0004896 cytokine receptor activity GO:0005021 vascular endothelial growth factor-activated receptor activity GO:0019199 transmembrane receptor protein kinase activity GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0035259 glucocorticoid receptor binding GO:0051427 hormone receptor binding |
Cellular Component |
GO:0005788 endoplasmic reticulum lumen |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | FLT3 |
Name | fms-related tyrosine kinase 3 |
Aliases | FLK2; CD135; FLK-2; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; g ...... |
Chromosomal Location | 13q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FLT3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FLT3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FLT3 |
Name | fms-related tyrosine kinase 3 |
Aliases | FLK2; CD135; FLK-2; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; g ...... |
Chromosomal Location | 13q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FLT3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FLT3 |
Name | fms-related tyrosine kinase 3 |
Aliases | FLK2; CD135; FLK-2; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; g ...... |
Chromosomal Location | 13q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FLT3 in various data sets.
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Points in the above scatter plot represent the mutation difference of FLT3 in various data sets.
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Summary | |
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Symbol | FLT3 |
Name | fms-related tyrosine kinase 3 |
Aliases | FLK2; CD135; FLK-2; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; g ...... |
Chromosomal Location | 13q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FLT3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FLT3 |
Name | fms-related tyrosine kinase 3 |
Aliases | FLK2; CD135; FLK-2; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; g ...... |
Chromosomal Location | 13q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FLT3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FLT3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FLT3 |
Name | fms-related tyrosine kinase 3 |
Aliases | FLK2; CD135; FLK-2; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; g ...... |
Chromosomal Location | 13q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FLT3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FLT3 |
Name | fms-related tyrosine kinase 3 |
Aliases | FLK2; CD135; FLK-2; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; g ...... |
Chromosomal Location | 13q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FLT3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FLT3 |
Name | fms-related tyrosine kinase 3 |
Aliases | FLK2; CD135; FLK-2; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; g ...... |
Chromosomal Location | 13q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FLT3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FLT3 |
Name | fms-related tyrosine kinase 3 |
Aliases | FLK2; CD135; FLK-2; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; g ...... |
Chromosomal Location | 13q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FLT3 collected from DrugBank database. |
Details on drugs targeting FLT3.
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