Summary | |
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Symbol | FMOD |
Name | fibromodulin |
Aliases | SLRR2E; fibromodulin proteoglycan; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate p ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Domain |
PF13855 Leucine rich repeat PF01462 Leucine rich repeat N-terminal domain |
Function |
Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). |
Biological Process |
GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006026 aminoglycan catabolic process GO:0006027 glycosaminoglycan catabolic process GO:0006790 sulfur compound metabolic process GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007181 transforming growth factor beta receptor complex assembly GO:0007409 axonogenesis GO:0018146 keratan sulfate biosynthetic process GO:0030198 extracellular matrix organization GO:0030199 collagen fibril organization GO:0030203 glycosaminoglycan metabolic process GO:0042339 keratan sulfate metabolic process GO:0042340 keratan sulfate catabolic process GO:0043062 extracellular structure organization GO:0044272 sulfur compound biosynthetic process GO:0044273 sulfur compound catabolic process GO:0048667 cell morphogenesis involved in neuron differentiation GO:0061564 axon development GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:1901136 carbohydrate derivative catabolic process GO:1901565 organonitrogen compound catabolic process GO:1903510 mucopolysaccharide metabolic process |
Molecular Function |
GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005775 vacuolar lumen GO:0005796 Golgi lumen GO:0043202 lysosomal lumen |
KEGG | - |
Reactome |
R-HSA-3656244: Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) R-HSA-3656225: Defective CHST6 causes MCDC1 R-HSA-3656243: Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-1643685: Disease R-HSA-3560782: Diseases associated with glycosaminoglycan metabolism R-HSA-3781865: Diseases of glycosylation R-HSA-3000178: ECM proteoglycans R-HSA-1474244: Extracellular matrix organization R-HSA-1630316: Glycosaminoglycan metabolism R-HSA-2022854: Keratan sulfate biosynthesis R-HSA-2022857: Keratan sulfate degradation R-HSA-1638074: Keratan sulfate/keratin metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
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Symbol | FMOD |
Name | fibromodulin |
Aliases | SLRR2E; fibromodulin proteoglycan; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate p ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FMOD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FMOD and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FMOD |
Name | fibromodulin |
Aliases | SLRR2E; fibromodulin proteoglycan; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate p ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FMOD in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FMOD |
Name | fibromodulin |
Aliases | SLRR2E; fibromodulin proteoglycan; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate p ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FMOD in various data sets.
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Points in the above scatter plot represent the mutation difference of FMOD in various data sets.
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Summary | |
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Symbol | FMOD |
Name | fibromodulin |
Aliases | SLRR2E; fibromodulin proteoglycan; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate p ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FMOD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FMOD |
Name | fibromodulin |
Aliases | SLRR2E; fibromodulin proteoglycan; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate p ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FMOD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FMOD. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | FMOD |
Name | fibromodulin |
Aliases | SLRR2E; fibromodulin proteoglycan; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate p ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FMOD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FMOD |
Name | fibromodulin |
Aliases | SLRR2E; fibromodulin proteoglycan; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate p ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FMOD expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FMOD |
Name | fibromodulin |
Aliases | SLRR2E; fibromodulin proteoglycan; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate p ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FMOD and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FMOD |
Name | fibromodulin |
Aliases | SLRR2E; fibromodulin proteoglycan; FM; KSPG fibromodulin; collagen-binding 59 kDa protein; keratan sulfate p ...... |
Chromosomal Location | 1q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FMOD collected from DrugBank database. |
There is no record. |