Summary | |
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Symbol | FOLH1 |
Name | folate hydrolase (prostate-specific membrane antigen) 1 |
Aliases | PSMA; NAALAD1; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; FOLH; FGCP; mGCP; N-acetylate ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type II membrane protein ; SUBCELLULAR LOCATION: Isoform PSMA': Cytoplasm |
Domain |
PF02225 PA domain PF04389 Peptidase family M28 PF04253 Transferrin receptor-like dimerisation domain |
Function |
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.; FUNCTION: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
Biological Process |
GO:0006520 cellular amino acid metabolic process GO:0006575 cellular modified amino acid metabolic process GO:0006732 coenzyme metabolic process GO:0006760 folic acid-containing compound metabolic process GO:0008652 cellular amino acid biosynthetic process GO:0016053 organic acid biosynthetic process GO:0018200 peptidyl-glutamic acid modification GO:0018410 C-terminal protein amino acid modification GO:0035608 protein deglutamylation GO:0035609 C-terminal protein deglutamylation GO:0042558 pteridine-containing compound metabolic process GO:0043687 post-translational protein modification GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0051186 cofactor metabolic process |
Molecular Function |
GO:0004180 carboxypeptidase activity GO:0004181 metallocarboxypeptidase activity GO:0008235 metalloexopeptidase activity GO:0008237 metallopeptidase activity GO:0008238 exopeptidase activity GO:0016805 dipeptidase activity GO:0033218 amide binding GO:0042277 peptide binding GO:1900750 oligopeptide binding GO:1904492 Ac-Asp-Glu binding GO:1904493 tetrahydrofolyl-poly(glutamate) polymer binding |
Cellular Component | - |
KEGG |
hsa04977 Vitamin digestion and absorption hsa00250 Alanine, aspartate and glutamate metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-70614: Amino acid synthesis and interconversion (transamination) R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives |
Summary | |
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Symbol | FOLH1 |
Name | folate hydrolase (prostate-specific membrane antigen) 1 |
Aliases | PSMA; NAALAD1; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; FOLH; FGCP; mGCP; N-acetylate ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FOLH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FOLH1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FOLH1 |
Name | folate hydrolase (prostate-specific membrane antigen) 1 |
Aliases | PSMA; NAALAD1; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; FOLH; FGCP; mGCP; N-acetylate ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FOLH1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FOLH1 |
Name | folate hydrolase (prostate-specific membrane antigen) 1 |
Aliases | PSMA; NAALAD1; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; FOLH; FGCP; mGCP; N-acetylate ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FOLH1 in various data sets.
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Points in the above scatter plot represent the mutation difference of FOLH1 in various data sets.
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Summary | |
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Symbol | FOLH1 |
Name | folate hydrolase (prostate-specific membrane antigen) 1 |
Aliases | PSMA; NAALAD1; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; FOLH; FGCP; mGCP; N-acetylate ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FOLH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FOLH1 |
Name | folate hydrolase (prostate-specific membrane antigen) 1 |
Aliases | PSMA; NAALAD1; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; FOLH; FGCP; mGCP; N-acetylate ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FOLH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FOLH1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FOLH1 |
Name | folate hydrolase (prostate-specific membrane antigen) 1 |
Aliases | PSMA; NAALAD1; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; FOLH; FGCP; mGCP; N-acetylate ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FOLH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FOLH1 |
Name | folate hydrolase (prostate-specific membrane antigen) 1 |
Aliases | PSMA; NAALAD1; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; FOLH; FGCP; mGCP; N-acetylate ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FOLH1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FOLH1 |
Name | folate hydrolase (prostate-specific membrane antigen) 1 |
Aliases | PSMA; NAALAD1; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; FOLH; FGCP; mGCP; N-acetylate ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FOLH1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FOLH1 |
Name | folate hydrolase (prostate-specific membrane antigen) 1 |
Aliases | PSMA; NAALAD1; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; FOLH; FGCP; mGCP; N-acetylate ...... |
Chromosomal Location | 11p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FOLH1 collected from DrugBank database. |
Details on drugs targeting FOLH1.
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