Summary | |
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Symbol | FOLR1 |
Name | folate receptor 1 (adult) |
Aliases | FOLR; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor, adult; ...... |
Chromosomal Location | 11q13.3-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. |
Domain |
PF03024 Folate receptor family |
Function |
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
Biological Process |
GO:0001101 response to acid chemical GO:0001667 ameboidal-type cell migration GO:0001755 neural crest cell migration GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001947 heart looping GO:0003007 heart morphogenesis GO:0003143 embryonic heart tube morphogenesis GO:0003147 neural crest cell migration involved in heart formation GO:0003151 outflow tract morphogenesis GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0006575 cellular modified amino acid metabolic process GO:0006732 coenzyme metabolic process GO:0006760 folic acid-containing compound metabolic process GO:0006766 vitamin metabolic process GO:0006767 water-soluble vitamin metabolic process GO:0006888 ER to Golgi vesicle-mediated transport GO:0006898 receptor-mediated endocytosis GO:0006900 membrane budding GO:0006901 vesicle coating GO:0006903 vesicle targeting GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007368 determination of left/right symmetry GO:0007389 pattern specification process GO:0007507 heart development GO:0007584 response to nutrient GO:0009799 specification of symmetry GO:0009855 determination of bilateral symmetry GO:0009991 response to extracellular stimulus GO:0014020 primary neural tube formation GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0015849 organic acid transport GO:0015884 folic acid transport GO:0016050 vesicle organization GO:0016055 Wnt signaling pathway GO:0016331 morphogenesis of embryonic epithelium GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO:0021915 neural tube development GO:0030111 regulation of Wnt signaling pathway GO:0031099 regeneration GO:0031102 neuron projection regeneration GO:0031103 axon regeneration GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031670 cellular response to nutrient GO:0033273 response to vitamin GO:0035050 embryonic heart tube development GO:0035051 cardiocyte differentiation GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0042558 pteridine-containing compound metabolic process GO:0042886 amide transport GO:0046655 folic acid metabolic process GO:0048193 Golgi vesicle transport GO:0048199 vesicle targeting, to, from or within Golgi GO:0048207 vesicle targeting, rough ER to cis-Golgi GO:0048208 COPII vesicle coating GO:0048514 blood vessel morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048645 animal organ formation GO:0048678 response to axon injury GO:0048762 mesenchymal cell differentiation GO:0048844 artery morphogenesis GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0051180 vitamin transport GO:0051181 cofactor transport GO:0051186 cofactor metabolic process GO:0051593 response to folic acid GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0060037 pharyngeal system development GO:0060070 canonical Wnt signaling pathway GO:0060485 mesenchyme development GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0060828 regulation of canonical Wnt signaling pathway GO:0060840 artery development GO:0060914 heart formation GO:0060973 cell migration involved in heart development GO:0060974 cell migration involved in heart formation GO:0061307 cardiac neural crest cell differentiation involved in heart development GO:0061308 cardiac neural crest cell development involved in heart development GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis GO:0061371 determination of heart left/right asymmetry GO:0061564 axon development GO:0061626 pharyngeal arch artery morphogenesis GO:0061713 anterior neural tube closure GO:0071229 cellular response to acid chemical GO:0071231 cellular response to folic acid GO:0071295 cellular response to vitamin GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071496 cellular response to external stimulus GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0072175 epithelial tube formation GO:0072337 modified amino acid transport GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090114 COPII-coated vesicle budding GO:0090287 regulation of cellular response to growth factor stimulus GO:0198738 cell-cell signaling by wnt GO:1903844 regulation of cellular response to transforming growth factor beta stimulus |
Molecular Function |
GO:0005542 folic acid binding GO:0008144 drug binding GO:0008517 folic acid transporter activity GO:0019842 vitamin binding GO:0031406 carboxylic acid binding GO:0033218 amide binding GO:0038024 cargo receptor activity GO:0043168 anion binding GO:0043177 organic acid binding GO:0051183 vitamin transporter activity GO:0051184 cofactor transporter activity GO:0051870 methotrexate binding GO:0061714 folic acid receptor activity GO:0072341 modified amino acid binding |
Cellular Component |
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0005903 brush border GO:0009897 external side of plasma membrane GO:0012507 ER to Golgi transport vesicle membrane GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0031225 anchored component of membrane GO:0031233 intrinsic component of external side of plasma membrane GO:0031253 cell projection membrane GO:0031362 anchored component of external side of plasma membrane GO:0031526 brush border membrane GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0045177 apical part of cell GO:0046658 anchored component of plasma membrane GO:0098552 side of membrane GO:0098862 cluster of actin-based cell projections |
KEGG |
hsa04144 Endocytosis |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6807878: COPI-mediated anterograde transport R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-5694530: Cargo concentration in the ER R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | FOLR1 |
Name | folate receptor 1 (adult) |
Aliases | FOLR; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor, adult; ...... |
Chromosomal Location | 11q13.3-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FOLR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FOLR1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FOLR1 |
Name | folate receptor 1 (adult) |
Aliases | FOLR; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor, adult; ...... |
Chromosomal Location | 11q13.3-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FOLR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FOLR1 |
Name | folate receptor 1 (adult) |
Aliases | FOLR; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor, adult; ...... |
Chromosomal Location | 11q13.3-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FOLR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of FOLR1 in various data sets.
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Summary | |
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Symbol | FOLR1 |
Name | folate receptor 1 (adult) |
Aliases | FOLR; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor, adult; ...... |
Chromosomal Location | 11q13.3-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FOLR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FOLR1 |
Name | folate receptor 1 (adult) |
Aliases | FOLR; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor, adult; ...... |
Chromosomal Location | 11q13.3-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FOLR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FOLR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FOLR1 |
Name | folate receptor 1 (adult) |
Aliases | FOLR; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor, adult; ...... |
Chromosomal Location | 11q13.3-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FOLR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FOLR1 |
Name | folate receptor 1 (adult) |
Aliases | FOLR; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor, adult; ...... |
Chromosomal Location | 11q13.3-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FOLR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FOLR1 |
Name | folate receptor 1 (adult) |
Aliases | FOLR; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor, adult; ...... |
Chromosomal Location | 11q13.3-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FOLR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FOLR1 |
Name | folate receptor 1 (adult) |
Aliases | FOLR; FR-alpha; KB cells FBP; adult folate-binding protein; folate binding protein; folate receptor, adult; ...... |
Chromosomal Location | 11q13.3-q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FOLR1 collected from DrugBank database. |
Details on drugs targeting FOLR1.
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