Browse FOXB1

Summary
SymbolFOXB1
Nameforkhead box B1
Aliases HFKH-5; FKH5; transcription factor FKH-5; Forkhead box protein B1
Chromosomal Location15q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00250 Forkhead domain
Function

-

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001756 somitogenesis
GO:0003002 regionalization
GO:0007389 pattern specification process
GO:0007409 axonogenesis
GO:0007412 axon target recognition
GO:0007589 body fluid secretion
GO:0007595 lactation
GO:0007611 learning or memory
GO:0007612 learning
GO:0007632 visual behavior
GO:0008306 associative learning
GO:0008542 visual learning
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009952 anterior/posterior pattern specification
GO:0021510 spinal cord development
GO:0021536 diencephalon development
GO:0021537 telencephalon development
GO:0021761 limbic system development
GO:0021767 mammillary body development
GO:0021794 thalamus development
GO:0021854 hypothalamus development
GO:0021855 hypothalamus cell migration
GO:0021885 forebrain cell migration
GO:0021915 neural tube development
GO:0022029 telencephalon cell migration
GO:0030879 mammary gland development
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0032941 secretion by tissue
GO:0033504 floor plate development
GO:0035282 segmentation
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044708 single-organism behavior
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048732 gland development
GO:0050878 regulation of body fluid levels
GO:0050890 cognition
GO:0051402 neuron apoptotic process
GO:0060644 mammary gland epithelial cell differentiation
GO:0060749 mammary gland alveolus development
GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development
GO:0061053 somite development
GO:0061180 mammary gland epithelium development
GO:0061373 mammillary axonal complex development
GO:0061374 mammillothalamic axonal tract development
GO:0061377 mammary gland lobule development
GO:0061378 corpora quadrigemina development
GO:0061379 inferior colliculus development
GO:0061381 cell migration in diencephalon
GO:0061564 axon development
GO:0070997 neuron death
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolFOXB1
Nameforkhead box B1
Aliases HFKH-5; FKH5; transcription factor FKH-5; Forkhead box protein B1
Chromosomal Location15q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FOXB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolFOXB1
Nameforkhead box B1
Aliases HFKH-5; FKH5; transcription factor FKH-5; Forkhead box protein B1
Chromosomal Location15q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FOXB1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.39; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFOXB1
Nameforkhead box B1
Aliases HFKH-5; FKH5; transcription factor FKH-5; Forkhead box protein B1
Chromosomal Location15q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FOXB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.910.394
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.7440.253
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.150.931
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.020.906
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FOXB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFOXB1
Nameforkhead box B1
Aliases HFKH-5; FKH5; transcription factor FKH-5; Forkhead box protein B1
Chromosomal Location15q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FOXB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFOXB1
Nameforkhead box B1
Aliases HFKH-5; FKH5; transcription factor FKH-5; Forkhead box protein B1
Chromosomal Location15q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FOXB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FOXB1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFOXB1
Nameforkhead box B1
Aliases HFKH-5; FKH5; transcription factor FKH-5; Forkhead box protein B1
Chromosomal Location15q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FOXB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFOXB1
Nameforkhead box B1
Aliases HFKH-5; FKH5; transcription factor FKH-5; Forkhead box protein B1
Chromosomal Location15q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FOXB1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFOXB1
Nameforkhead box B1
Aliases HFKH-5; FKH5; transcription factor FKH-5; Forkhead box protein B1
Chromosomal Location15q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FOXB1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFOXB1
Nameforkhead box B1
Aliases HFKH-5; FKH5; transcription factor FKH-5; Forkhead box protein B1
Chromosomal Location15q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FOXB1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.