Browse FOXJ1

Summary
SymbolFOXJ1
Nameforkhead box J1
Aliases HFH-4; HFH4; FKHL13; fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead- ......
Chromosomal Location17q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00250 Forkhead domain
Function

Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T).

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001818 negative regulation of cytokine production
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0002064 epithelial cell development
GO:0002250 adaptive immune response
GO:0002443 leukocyte mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002455 humoral immune response mediated by circulating immunoglobulin
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002467 germinal center formation
GO:0002507 tolerance induction
GO:0002508 central tolerance induction
GO:0002510 central B cell tolerance induction
GO:0002514 B cell tolerance induction
GO:0002521 leukocyte differentiation
GO:0002634 regulation of germinal center formation
GO:0002635 negative regulation of germinal center formation
GO:0002643 regulation of tolerance induction
GO:0002645 positive regulation of tolerance induction
GO:0002646 regulation of central tolerance induction
GO:0002648 positive regulation of central tolerance induction
GO:0002661 regulation of B cell tolerance induction
GO:0002663 positive regulation of B cell tolerance induction
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002698 negative regulation of immune effector process
GO:0002703 regulation of leukocyte mediated immunity
GO:0002704 negative regulation of leukocyte mediated immunity
GO:0002706 regulation of lymphocyte mediated immunity
GO:0002707 negative regulation of lymphocyte mediated immunity
GO:0002712 regulation of B cell mediated immunity
GO:0002713 negative regulation of B cell mediated immunity
GO:0002819 regulation of adaptive immune response
GO:0002820 negative regulation of adaptive immune response
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002889 regulation of immunoglobulin mediated immune response
GO:0002890 negative regulation of immunoglobulin mediated immune response
GO:0002895 regulation of central B cell tolerance induction
GO:0002897 positive regulation of central B cell tolerance induction
GO:0002920 regulation of humoral immune response
GO:0002921 negative regulation of humoral immune response
GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0003002 regionalization
GO:0003338 metanephros morphogenesis
GO:0006959 humoral immune response
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007283 spermatogenesis
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0007507 heart development
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0010927 cellular component assembly involved in morphogenesis
GO:0016064 immunoglobulin mediated immune response
GO:0019724 B cell mediated immunity
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0030010 establishment of cell polarity
GO:0030031 cell projection assembly
GO:0030098 lymphocyte differentiation
GO:0030217 T cell differentiation
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032635 interleukin-6 production
GO:0032675 regulation of interleukin-6 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032835 glomerulus development
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032945 negative regulation of mononuclear cell proliferation
GO:0033077 T cell differentiation in thymus
GO:0033081 regulation of T cell differentiation in thymus
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0035089 establishment of apical/basal cell polarity
GO:0035502 metanephric part of ureteric bud development
GO:0035850 epithelial cell differentiation involved in kidney development
GO:0042035 regulation of cytokine biosynthetic process
GO:0042036 negative regulation of cytokine biosynthetic process
GO:0042089 cytokine biosynthetic process
GO:0042098 T cell proliferation
GO:0042107 cytokine metabolic process
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042129 regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0042226 interleukin-6 biosynthetic process
GO:0042384 cilium assembly
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044782 cilium organization
GO:0045408 regulation of interleukin-6 biosynthetic process
GO:0045409 negative regulation of interleukin-6 biosynthetic process
GO:0045580 regulation of T cell differentiation
GO:0045581 negative regulation of T cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045620 negative regulation of lymphocyte differentiation
GO:0046651 lymphocyte proliferation
GO:0048232 male gamete generation
GO:0050670 regulation of lymphocyte proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050777 negative regulation of immune response
GO:0050863 regulation of T cell activation
GO:0050864 regulation of B cell activation
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0050868 negative regulation of T cell activation
GO:0050869 negative regulation of B cell activation
GO:0050900 leukocyte migration
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0060271 cilium morphogenesis
GO:0060428 lung epithelium development
GO:0060479 lung cell differentiation
GO:0060487 lung epithelial cell differentiation
GO:0060541 respiratory system development
GO:0060972 left/right pattern formation
GO:0060993 kidney morphogenesis
GO:0061005 cell differentiation involved in kidney development
GO:0061141 lung ciliated cell differentiation
GO:0061162 establishment of monopolar cell polarity
GO:0061245 establishment or maintenance of bipolar cell polarity
GO:0061339 establishment or maintenance of monopolar cell polarity
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070664 negative regulation of leukocyte proliferation
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072010 glomerular epithelium development
GO:0072016 glomerular parietal epithelial cell development
GO:0072073 kidney epithelium development
GO:0072139 glomerular parietal epithelial cell differentiation
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072310 glomerular epithelial cell development
GO:0072311 glomerular epithelial cell differentiation
GO:0090630 activation of GTPase activity
GO:1901246 regulation of lung ciliated cell differentiation
GO:1901248 positive regulation of lung ciliated cell differentiation
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:2000398 regulation of thymocyte aggregation
GO:2000399 negative regulation of thymocyte aggregation
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolFOXJ1
Nameforkhead box J1
Aliases HFH-4; HFH4; FKHL13; fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead- ......
Chromosomal Location17q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FOXJ1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolFOXJ1
Nameforkhead box J1
Aliases HFH-4; HFH4; FKHL13; fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead- ......
Chromosomal Location17q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FOXJ1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFOXJ1
Nameforkhead box J1
Aliases HFH-4; HFH4; FKHL13; fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead- ......
Chromosomal Location17q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FOXJ1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0910.718
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6720.207
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3330.447
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9162.4940.0192
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 593.0370.0469
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.8190.337
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0580.883
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0730.899
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.7260.0618
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FOXJ1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFOXJ1
Nameforkhead box J1
Aliases HFH-4; HFH4; FKHL13; fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead- ......
Chromosomal Location17q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FOXJ1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFOXJ1
Nameforkhead box J1
Aliases HFH-4; HFH4; FKHL13; fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead- ......
Chromosomal Location17q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FOXJ1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FOXJ1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFOXJ1
Nameforkhead box J1
Aliases HFH-4; HFH4; FKHL13; fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead- ......
Chromosomal Location17q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FOXJ1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFOXJ1
Nameforkhead box J1
Aliases HFH-4; HFH4; FKHL13; fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead- ......
Chromosomal Location17q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FOXJ1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFOXJ1
Nameforkhead box J1
Aliases HFH-4; HFH4; FKHL13; fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead- ......
Chromosomal Location17q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FOXJ1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFOXJ1
Nameforkhead box J1
Aliases HFH-4; HFH4; FKHL13; fork head homologue 4; forkhead transcription factor HFH-4; forkhead-like 13; forkhead- ......
Chromosomal Location17q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FOXJ1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.