Browse FOXL1

Summary
SymbolFOXL1
Nameforkhead box L1
Aliases FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ......
Chromosomal Location16q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00250 Forkhead domain
Function

Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).

> Gene Ontology
 
Biological Process GO:0006029 proteoglycan metabolic process
GO:0007494 midgut development
GO:0007495 visceral mesoderm-endoderm interaction involved in midgut development
GO:0007507 heart development
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0016055 Wnt signaling pathway
GO:0030111 regulation of Wnt signaling pathway
GO:0030166 proteoglycan biosynthetic process
GO:0048537 mucosal-associated lymphoid tissue development
GO:0048541 Peyer's patch development
GO:0048565 digestive tract development
GO:0055123 digestive system development
GO:0061146 Peyer's patch morphogenesis
GO:0198738 cell-cell signaling by wnt
Molecular Function GO:0008301 DNA binding, bending
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolFOXL1
Nameforkhead box L1
Aliases FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ......
Chromosomal Location16q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FOXL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolFOXL1
Nameforkhead box L1
Aliases FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ......
Chromosomal Location16q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FOXL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFOXL1
Nameforkhead box L1
Aliases FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ......
Chromosomal Location16q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FOXL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0520.00303
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.4250.019
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7830.142
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.6070.208
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3010.78
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.9970.458
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3010.478
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6230.387
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1340.854
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1170.822
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4010.552
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7250.000515
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FOXL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFOXL1
Nameforkhead box L1
Aliases FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ......
Chromosomal Location16q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FOXL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFOXL1
Nameforkhead box L1
Aliases FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ......
Chromosomal Location16q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FOXL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FOXL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFOXL1
Nameforkhead box L1
Aliases FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ......
Chromosomal Location16q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FOXL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFOXL1
Nameforkhead box L1
Aliases FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ......
Chromosomal Location16q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FOXL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFOXL1
Nameforkhead box L1
Aliases FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ......
Chromosomal Location16q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FOXL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFOXL1
Nameforkhead box L1
Aliases FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ......
Chromosomal Location16q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FOXL1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.