Summary | |
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Symbol | FOXL1 |
Name | forkhead box L1 |
Aliases | FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ...... |
Chromosomal Location | 16q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00250 Forkhead domain |
Function |
Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity). |
Biological Process |
GO:0006029 proteoglycan metabolic process GO:0007494 midgut development GO:0007495 visceral mesoderm-endoderm interaction involved in midgut development GO:0007507 heart development GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0016055 Wnt signaling pathway GO:0030111 regulation of Wnt signaling pathway GO:0030166 proteoglycan biosynthetic process GO:0048537 mucosal-associated lymphoid tissue development GO:0048541 Peyer's patch development GO:0048565 digestive tract development GO:0055123 digestive system development GO:0061146 Peyer's patch morphogenesis GO:0198738 cell-cell signaling by wnt |
Molecular Function |
GO:0008301 DNA binding, bending |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | FOXL1 |
Name | forkhead box L1 |
Aliases | FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ...... |
Chromosomal Location | 16q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FOXL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | FOXL1 |
Name | forkhead box L1 |
Aliases | FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ...... |
Chromosomal Location | 16q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FOXL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FOXL1 |
Name | forkhead box L1 |
Aliases | FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ...... |
Chromosomal Location | 16q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FOXL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of FOXL1 in various data sets.
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Summary | |
---|---|
Symbol | FOXL1 |
Name | forkhead box L1 |
Aliases | FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ...... |
Chromosomal Location | 16q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FOXL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | FOXL1 |
Name | forkhead box L1 |
Aliases | FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ...... |
Chromosomal Location | 16q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FOXL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FOXL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FOXL1 |
Name | forkhead box L1 |
Aliases | FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ...... |
Chromosomal Location | 16q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FOXL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | FOXL1 |
Name | forkhead box L1 |
Aliases | FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ...... |
Chromosomal Location | 16q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FOXL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | FOXL1 |
Name | forkhead box L1 |
Aliases | FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ...... |
Chromosomal Location | 16q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FOXL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | FOXL1 |
Name | forkhead box L1 |
Aliases | FREAC7; FKH6; FKHL11; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription fact ...... |
Chromosomal Location | 16q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FOXL1 collected from DrugBank database. |
There is no record. |