Browse FOXM1

Summary
SymbolFOXM1
Nameforkhead box M1
Aliases HFH-11; trident; HNF-3; INS-1; MPHOSPH2; TGT3; M-phase phosphoprotein 2; FKHL16; FKHL16B; HFH11; MPP-2; PIG2 ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00250 Forkhead domain
Function

Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.

> Gene Ontology
 
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
GO:0001933 negative regulation of protein phosphorylation
GO:0006282 regulation of DNA repair
GO:0006302 double-strand break repair
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050 cell cycle arrest
GO:0007265 Ras protein signal transduction
GO:0007568 aging
GO:0007569 cell aging
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0042326 negative regulation of phosphorylation
GO:0042770 signal transduction in response to DNA damage
GO:0042772 DNA damage response, signal transduction resulting in transcription
GO:0043409 negative regulation of MAPK cascade
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044839 cell cycle G2/M phase transition
GO:0045739 positive regulation of DNA repair
GO:0045786 negative regulation of cell cycle
GO:0046578 regulation of Ras protein signal transduction
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051403 stress-activated MAPK cascade
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade
GO:0071156 regulation of cell cycle arrest
GO:0072331 signal transduction by p53 class mediator
GO:0072593 reactive oxygen species metabolic process
GO:0090342 regulation of cell aging
GO:0090344 negative regulation of cell aging
GO:1902532 negative regulation of intracellular signal transduction
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000779 regulation of double-strand break repair
GO:2000781 positive regulation of double-strand break repair
GO:2001020 regulation of response to DNA damage stimulus
GO:2001022 positive regulation of response to DNA damage stimulus
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-69273: Cyclin A/B1 associated events during G2/M transition
R-HSA-69275: G2/M Transition
R-HSA-453274: Mitotic G2-G2/M phases
R-HSA-156711: Polo-like kinase mediated events
Summary
SymbolFOXM1
Nameforkhead box M1
Aliases HFH-11; trident; HNF-3; INS-1; MPHOSPH2; TGT3; M-phase phosphoprotein 2; FKHL16; FKHL16B; HFH11; MPP-2; PIG2 ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FOXM1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between FOXM1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
22139074Lung CarcinomaInhibit immunityAblation of Foxm1 in macrophages reduced the number and size of lung tumors in macFoxm1(-/-) mice. The expression levels of the pro-inflammatory genes iNOS, Cox-2, interleukin-1b (IL-1b) and IL-6, as well as the migration-related genes macrophage inflammatory protein-1 (MIP-1α), MIP-2 and MMP-12, were decreased in macrophages isolated from macFoxm1(-/-) mice. The chemokine receptors responsible for monocyte recruitment to the lung, CX(3)CR1 and CXCR4, were decreased in Foxm1-deficient monocytes. In co-transfection experiments, Foxm1 directly bound to and transcriptionally activated the CX(3)CR1 promoter. Expression of Foxm1 in macrophages is required for pulmonary inflammation, recruitment of macrophages into tumor sites and lung tumor growth.
Summary
SymbolFOXM1
Nameforkhead box M1
Aliases HFH-11; trident; HNF-3; INS-1; MPHOSPH2; TGT3; M-phase phosphoprotein 2; FKHL16; FKHL16B; HFH11; MPP-2; PIG2 ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FOXM1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.66 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolFOXM1
Nameforkhead box M1
Aliases HFH-11; trident; HNF-3; INS-1; MPHOSPH2; TGT3; M-phase phosphoprotein 2; FKHL16; FKHL16B; HFH11; MPP-2; PIG2 ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FOXM1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4190.236
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3570.846
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4660.738
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.6620.128
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.0550.581
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1780.948
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.170.677
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2580.86
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7240.633
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0130.992
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2430.89
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.5250.000243
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FOXM1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.11.49.70.0589
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.11.79.40.0895
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolFOXM1
Nameforkhead box M1
Aliases HFH-11; trident; HNF-3; INS-1; MPHOSPH2; TGT3; M-phase phosphoprotein 2; FKHL16; FKHL16B; HFH11; MPP-2; PIG2 ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FOXM1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFOXM1
Nameforkhead box M1
Aliases HFH-11; trident; HNF-3; INS-1; MPHOSPH2; TGT3; M-phase phosphoprotein 2; FKHL16; FKHL16B; HFH11; MPP-2; PIG2 ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FOXM1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FOXM1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFOXM1
Nameforkhead box M1
Aliases HFH-11; trident; HNF-3; INS-1; MPHOSPH2; TGT3; M-phase phosphoprotein 2; FKHL16; FKHL16B; HFH11; MPP-2; PIG2 ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FOXM1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFOXM1
Nameforkhead box M1
Aliases HFH-11; trident; HNF-3; INS-1; MPHOSPH2; TGT3; M-phase phosphoprotein 2; FKHL16; FKHL16B; HFH11; MPP-2; PIG2 ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FOXM1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFOXM1
Nameforkhead box M1
Aliases HFH-11; trident; HNF-3; INS-1; MPHOSPH2; TGT3; M-phase phosphoprotein 2; FKHL16; FKHL16B; HFH11; MPP-2; PIG2 ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FOXM1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFOXM1
Nameforkhead box M1
Aliases HFH-11; trident; HNF-3; INS-1; MPHOSPH2; TGT3; M-phase phosphoprotein 2; FKHL16; FKHL16B; HFH11; MPP-2; PIG2 ......
Chromosomal Location12p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FOXM1 collected from DrugBank database.
> Drugs from DrugBank database
 

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