Summary | |
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Symbol | FOXP1 |
Name | forkhead box P1 |
Aliases | QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ...... |
Chromosomal Location | 3p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Note=Not found in the nucleolus. |
Domain |
PF00250 Forkhead domain PF16159 FOXP coiled-coil domain |
Function |
Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). ; FUNCTION: Isoform 8: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity). |
Biological Process |
GO:0001501 skeletal system development GO:0001667 ameboidal-type cell migration GO:0001783 B cell apoptotic process GO:0002237 response to molecule of bacterial origin GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002287 alpha-beta T cell activation involved in immune response GO:0002292 T cell differentiation involved in immune response GO:0002293 alpha-beta T cell differentiation involved in immune response GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002761 regulation of myeloid leukocyte differentiation GO:0002831 regulation of response to biotic stimulus GO:0002902 regulation of B cell apoptotic process GO:0002903 negative regulation of B cell apoptotic process GO:0003158 endothelium development GO:0003159 morphogenesis of an endothelium GO:0007159 leukocyte cell-cell adhesion GO:0009306 protein secretion GO:0009755 hormone-mediated signaling pathway GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030217 T cell differentiation GO:0030224 monocyte differentiation GO:0030316 osteoclast differentiation GO:0030335 positive regulation of cell migration GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0032496 response to lipopolysaccharide GO:0032602 chemokine production GO:0032611 interleukin-1 beta production GO:0032612 interleukin-1 production GO:0032615 interleukin-12 production GO:0032625 interleukin-21 production GO:0032640 tumor necrosis factor production GO:0032651 regulation of interleukin-1 beta production GO:0032652 regulation of interleukin-1 production GO:0032655 regulation of interleukin-12 production GO:0032680 regulation of tumor necrosis factor production GO:0033002 muscle cell proliferation GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway GO:0035239 tube morphogenesis GO:0035710 CD4-positive, alpha-beta T cell activation GO:0035926 chemokine (C-C motif) ligand 2 secretion GO:0036035 osteoclast development GO:0036301 macrophage colony-stimulating factor production GO:0040017 positive regulation of locomotion GO:0042093 T-helper cell differentiation GO:0042110 T cell activation GO:0042116 macrophage activation GO:0042117 monocyte activation GO:0042118 endothelial cell activation GO:0042742 defense response to bacterium GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043401 steroid hormone mediated signaling pathway GO:0043542 endothelial cell migration GO:0043900 regulation of multi-organism process GO:0045637 regulation of myeloid cell differentiation GO:0045655 regulation of monocyte differentiation GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0048545 response to steroid hormone GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0050663 cytokine secretion GO:0050701 interleukin-1 secretion GO:0050702 interleukin-1 beta secretion GO:0050704 regulation of interleukin-1 secretion GO:0050706 regulation of interleukin-1 beta secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0051272 positive regulation of cellular component movement GO:0060348 bone development GO:0060562 epithelial tube morphogenesis GO:0060765 regulation of androgen receptor signaling pathway GO:0060766 negative regulation of androgen receptor signaling pathway GO:0061154 endothelial tube morphogenesis GO:0061470 T follicular helper cell differentiation GO:0061515 myeloid cell development GO:0070227 lymphocyte apoptotic process GO:0070228 regulation of lymphocyte apoptotic process GO:0070229 negative regulation of lymphocyte apoptotic process GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071593 lymphocyte aggregation GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071887 leukocyte apoptotic process GO:0072567 chemokine (C-X-C motif) ligand 2 production GO:0072610 interleukin-12 secretion GO:0072619 interleukin-21 secretion GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090195 chemokine secretion GO:0098542 defense response to other organism GO:0098751 bone cell development GO:1900424 regulation of defense response to bacterium GO:1901256 regulation of macrophage colony-stimulating factor production GO:1901509 regulation of endothelial tube morphogenesis GO:1902105 regulation of leukocyte differentiation GO:1903131 mononuclear cell differentiation GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903706 regulation of hemopoiesis GO:1905330 regulation of morphogenesis of an epithelium GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process GO:2000147 positive regulation of cell motility GO:2001182 regulation of interleukin-12 secretion |
Molecular Function |
GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0043621 protein self-association GO:0050681 androgen receptor binding GO:0051427 hormone receptor binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-452723: Transcriptional regulation of pluripotent stem cells |
Summary | |
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Symbol | FOXP1 |
Name | forkhead box P1 |
Aliases | QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ...... |
Chromosomal Location | 3p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between FOXP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between FOXP1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | FOXP1 |
Name | forkhead box P1 |
Aliases | QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ...... |
Chromosomal Location | 3p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of FOXP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | FOXP1 |
Name | forkhead box P1 |
Aliases | QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ...... |
Chromosomal Location | 3p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of FOXP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of FOXP1 in various data sets.
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Summary | |
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Symbol | FOXP1 |
Name | forkhead box P1 |
Aliases | QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ...... |
Chromosomal Location | 3p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FOXP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | FOXP1 |
Name | forkhead box P1 |
Aliases | QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ...... |
Chromosomal Location | 3p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FOXP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FOXP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | FOXP1 |
Name | forkhead box P1 |
Aliases | QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ...... |
Chromosomal Location | 3p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FOXP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | FOXP1 |
Name | forkhead box P1 |
Aliases | QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ...... |
Chromosomal Location | 3p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of FOXP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | FOXP1 |
Name | forkhead box P1 |
Aliases | QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ...... |
Chromosomal Location | 3p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between FOXP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | FOXP1 |
Name | forkhead box P1 |
Aliases | QRF1; 12CC4; HSPC215; hFKH1B; fork head-related protein like B; glutamine-rich factor 1; PAX5/FOXP1 fusion p ...... |
Chromosomal Location | 3p14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting FOXP1 collected from DrugBank database. |
There is no record. |